Cerebral Ischemia Induced Proteomic Alterations: Consequences for the Synapse and Organelles

Peer reviewed: YesNRC publication: Ye

A new intrinsic fluorescent probe for proteins. Biosynthetic incorporation of 5-hydroxytryptophan into oncomodulin: FEBS Lett.

NRC publication: Ye

Apoptotic human SH-SY5Y neuroblastoma cells have regularly spaced single strand DNA breaks and increased DNA-dependent protein kinase activity: Hum.Cell

NRC publication: Ye

Cerebral ischemia disrupts the expression of regulators of synaptic cell adhesion in synaptosomes

Dramatic and rapidly reversible structural changes are observed in dendritic spine morphology following excitotoxic or hypoxic stress1. However, morphological and biochemical alterations in post-synaptic densities persist for up to 24 hours following transient ischemia. This suggests that the synapse may be the origin of signals that propagate toward the cell body and instigate delayed post-ischemic neuronal death. Synaptically localized cell adhesion molecules are important regulators of synaptic plasticity and synaptogenesis. Regulation of cell adhesion and cytoskeletal structure in dendritic spines is necessary for the maintenance of mature synaptic connections. Therefore, we examined the effects of transient cerebral ischemia on the expression of synaptic proteins 20 hours post-ischemia.Peer reviewed: YesNRC publication: Ye

Detection of higher order 50 and 10 kbp DNA fragments before apoptotic internucleosomal cleavage following transient cerebral ischemia

NRC publication: Ye

Despite the internucleosomal cleavage of DNA, reactive oxygen species do not produce other markers of apoptosis in cultured meurons

NRC publication: Ye

Increased expression of the transcription factor E2F1 during dopamine-evoked, caspase-3-mediated apoptosis in rat cortical neurons

NRC publication: Ye

E2F1 modulates caspase-3-dependent neuronal apoptosis and contributes to neuronal injury following cerebral ischemia: J.Cereb.Blood Flow Metab.

NRC publication: Ye

Differences in DNA fragmentation following transient cerebral or decapitation ischemia in rats: J.Cereb.Blood Flow Metab.

NRC publication: Ye