Preconceptional factors associated with very low birthweight delivery in East and West Berlin: a case control study

BACKGROUND: Very low birthweight, i.e. a birthweight < 1500 g, is among the strongest determinants of infant mortality and childhood morbidity. To develop primary prevention approaches to VLBW birth and its sequelae, information is needed on the causes of preterm birth, their personal and social antecedents, and on conditions associated with very low birthweight. Despite the growing body of evidence linking sociodemographic variables with preterm delivery, little is known as to how this may be extrapolated to the risk of very low birthweight. METHODS: In 1992, two years after the German unification, we started to recruit two cohorts of very low birthweight infants and controls in East and West Berlin for a long-term neurodevelopmental study. The present analysis was undertaken to compare potential preconceptional risk factors for very low birthweight delivery in a case-control design including 166 mothers (82 East vs. 84 West Berlin) with very low birthweight delivery and 341 control mothers (166 East vs. 175 West). RESULTS: Multivariate logistic regression analysis was used to assess the effects of various dichotomous parental covariates and their interaction with living in East or West Berlin. After backward variable selection, short maternal school education, maternal unemployment, single-room apartment, smoking, previous preterm delivery, and fetal loss emerged as significant main effect variables, together with living in West Berlin as positive effect modificator for single-mother status. CONCLUSION: Very low birthweight has been differentially associated with obstetrical history and indicators of maternal socioeconomic status in East and West Berlin. The ranking of these risk factors is under the influence of the political framework

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

A genome-wide survival analysis of 14,406 Alzheimer's disease (AD) cases and 25,849 controls identified eight previously reported AD risk loci and 14 novel loci associated with age at onset. Linkage disequilibrium score regression of 220 cell types implicated the regulation of myeloid gene expression in AD risk. The minor allele of rs1057233 (G), within the previously reported CELF1 AD risk locus, showed association with delayed AD onset and lower expression of SPI1 in monocytes and macrophages. SPI1 encodes PU.1, a transcription factor critical for myeloid cell development and function. AD heritability was enriched within the PU.1 cistrome, implicating a myeloid PU.1 target gene network in AD. Finally, experimentally altered PU.1 levels affected the expression of mouse orthologs of many AD risk genes and the phagocytic activity of mouse microglial cells. Our results suggest that lower SPI1 expression reduces AD risk by regulating myeloid gene expression and cell function

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

The Muschelkalk aquifer of the Molasse basin in SW-Germany: implications on the origin and development of highly saline lithium-rich brines in calcareous hydrothermal reservoirs

Abstract Highly saline lithium-rich hydrothermal fluids (measured chloride concentration up to 44 g kg−1, lithium concentration up to 162 mg kg−1) occur in the deep calcareous Muschelkalk aquifer beneath the northern Alpine foreland (Molasse) basin. We have combined geologic, hydraulic, hydrochemical, and stress field data of the Triassic Muschelkalk aquifer beneath younger sediments of Triassic–Jurassic successions and the Cenozoic Molasse basin of SW-Germany for a synthesis to constrain the origin and development of these brines. In contrast to the regional southeast plunge of Jurassic and Cenozoic strata, low-gradient groundwater flow in the Upper Muschelkalk aquifer is to the north, induced by regional recharge from west, south, and east. The investigated area is seismically active and north trending maximum horizontal stress likely fosters development of necessary fracture permeability for northward flow in the competent carbonates of the Upper Muschelkalk aquifer. The highest lithium concentrations and total dissolved solids (TDS) can be found in the southern parts of the Muschelkalk aquifer. Here, the Muschelkalk Group overlays directly a crystalline basement swell separating two ENE-trending Permocarboniferous troughs. We argue that the highly saline lithium-rich fluids originate from fluid–rock interaction of meteoric water with Variscan crystalline basement rocks and entered the Muschelkalk aquifer on top of the basement swell by permeable faults and fractures. The marginal calcareous sand-rich facies of the Muschelkalk enables the inflow of brines from crystalline basement faults and fractures into the aquifer. We thus argue for an external origin of these brines into the aquifer and further intra-reservoir development by dilution with meteoric water

Induction of bilirubin-eliminating processes by methylphenobarbital in mature newborn babies

Peer Reviewe

GEO.Cool : Kühlung mit oberflächennaher Geothermie - Möglichkeiten, Grenzen, Innovation -

Das Verbundprojekt GEO.Cool von Partnern im Landesforschungszentrum Geothermie (LFZG) hat zum Ziel, Möglichkeiten sowie Grenzen der Kühlung mit oberflächennaher Geothermie in interdisziplinärer Arbeit zu erheben und daraus Impulse für Innovationen in diesem Bereich zu gewinnen. Das Vorhaben ist in die folgenden sechs Arbeitspakete (AP) gegliedert: AP 1: Bedarfe und Systemaspekte AP 2: Systemtechnik und Planung von Anlagen zur Kühlung mit oberflächennaher Ge-othermie AP 3: Analyse von Best-Practice-Beispielen AP 4: Thermisches und hydrogeologisches Verhalten des Untergrunds AP 5: Genehmigungspraxis und Grenzwerte AP 6: Synopse, Innovationspotenzial und Transfer. Das Projekt hat eine Laufzeit vom 23.01.2017 bis zum 30.09.2019 (Förderzeitraum für alle Arbeitspakete und Projektpartner)

GEO.Cool : Kühlung mit oberflächennaher Geothermie - Möglichkeiten, Grenzen, Innovation -

In dem durchgeführten Verbundvorhaben arbeiteten zum einen die Fachgebiete Geologie/Geothermie sowie Anlagen- und Systemtechnik von geothermischer Kältegewinnung und Kältenutzung der Projektpartner interdisziplinär zusammen, um den aktuellen Wissensstand der Kühlung mittels oberflächennaher Geothermie fachübergreifend zu erfassen, zu bewerten und Schnittstellenprobleme zu bearbeiten. Aus dieser interdisziplinären Betrachtungsweise wurden ganzheitliche Hinweise zur Optimierung des geothermischen Kühlpotenzials sowie Anstöße für technische und planerische Innovationen für die Praxis entwickelt und in diese transferiert. Zu folgenden Zielen wurden Beiträge erarbeitet: - Steigerung der Energieeffizienz der Kühlung und Kältebereitstellung - Nutzung regenerativer Energien zur Kühlung und Kältebereitstellung - Begrenzung der thermischen Belastung des Untergrunds und des Grundwassers - Minimierung der Schäden und Risiken durch den Eingriff in den Untergrun