Effective Route Maintenance and Restoration Schemes in Mobile Ad Hoc Networks

This study proposes a location-based hybrid routing protocol to improve data packet delivery and to reduce control message overhead in mobile ad hoc networks. In mobile environments, where nodes move continuously at a high speed, it is generally difficult to maintain and restore route paths. Therefore, this study suggests a new flooding mechanism to control route paths. The essence of the proposed scheme is its effective tracking of the destination’s location based on the beacon messages of the main route nodes. Through experiments based on an NS-2 simulator, the proposed scheme shows improvements in the data packet delivery ratio and reduces the amount of routing control message overhead compared with existing routing protocols such as AODV, LAR, ZRP and AODV-DFR

An Efficient Building Evacuation Algorithm in Congested Networks

This paper proposes a new network model for the building evacuation problem considering congestion levels and provides a mixed integer linear programming (MILP) model and an efficient heuristic algorithm solving the problem. Constructing an optimization model with several congestion levels, we introduce a new network called the multi-class time-expanded (MCTE) network having several exclusive arcs connecting the same tail and head nodes. The MCTE networks make both the MILP model and the heuristic algorithm reflect a realistic situation in congested networks. Considering MCTE networks makes the problem difficult to solve, which motivates us to develop an efficient heuristic algorithm. We test our heuristic algorithm using several real-world networks such as a multiplex cinema, a subway station, and a large-size complex shopping mall in addition to an artificial network for clear comparison between the proposed algorithm and the MILP approaches. The results indicate that the proposed algorithm runs fast and produces a near-optimal solution compared with those from MILP models with a commercial solver.11Ysciescopu

Leukotactin-1/CCL15-induced chemotaxis signaling through CCR1 in HOS cells

AbstractLeukotactin-1 (Lkn-1)/CCL15 is a recently cloned CC-chemokine that binds to the CCR1 and CCR3. Although Lkn-1 has been known to function as a chemoattractant for neutrophils, monocytes and lymphocytes, its cellular mechanism remains unclear. To understand the mechanism of Lkn-1-induced chemotaxis signaling, we examined the chemotactic activities of human osteogenic sarcoma cells expressing CCR1 in response to Lkn-1 using inhibitors of signaling molecules. Inhibitors of Gi/Go protein, phospholipase C (PLC) and protein kinase Cδ (PKCδ) inhibited the chemotactic activity of Lkn-1 indicating that Lkn-1-induced chemotaxis signal is transduced through Gi/Go protein, PLC and PKCδ. The activities of PLC and PKCδ were also enhanced by Lkn-1 stimulation. Chemotactic activity of Lkn-1 was inhibited by the treatment of cycloheximide and actinomycin D suggesting that newly synthesized proteins are needed for chemotaxis. Nuclear factor-κB (NF-κB) inhibitor reduced chemotactic activity of Lkn-1. DNA binding activity of NF-κB was also enhanced by Lkn-1 stimulation. These results suggest that Lkn-1 transduces the signal through Gi/Go protein, PLC, PKCδ, NF-κB and newly synthesized proteins for chemotaxis

Enriching Scholarly Knowledge with Context

Leveraging a GraphQL-based federated query service that integrates multiple scholarly communication infrastructures (specifically, DataCite, ORCID, ROR, OpenAIRE, Semantic Scholar, Wikidata and Altmetric), we develop a novel web widget based approach for the presentation of scholarly knowledge with rich contextual information. We implement the proposed approach in the Open Research Knowledge Graph (ORKG) and showcase it on three kinds of widgets. First, we devise a widget for the ORKG paper view that presents contextual information about related datasets, software, project information, topics, and metrics. Second, we extend the ORKG contributor profile view with contextual information including authored articles, developed software, linked projects, and research interests. Third, we advance ORKG comparison faceted search by introducing contextual facets (e.g. citations). As a result, the devised approach enables presenting ORKG scholarly knowledge flexibly enriched with contextual information sourced in a federated manner from numerous technologically heterogeneous scholarly communication infrastructures

Mammary gland tumors in a male Cocker Spaniel

Background Mammary gland tumors are the most common tumors in sexually intact female dogs; however, they are rare in male dogs. This study was conducted to investigate the relationship between sexual hormones and mammary gland tumors in a male dog. Case presentation A 13-year-old, intact male Cocker Spaniel presented to the Veterinary Teaching Hospital of Kangwon National University, Republic of Korea, with an acute right ruptured caudal abdominal mass. Physical examination revealed a 14 × 14 cm ruptured mass in the right caudal abdomen, as well as a 1.5 × 1.5 cm mass in the first right mammary gland. The estrogen and progesterone concentrations in serum were within normal levels. Total mastectomy was done on the right side mammary glands. Following surgery, the site was fully recovered; however, a mass that had grown to 2 × 2 cm was found in the left fifth mammary gland and a testis tumor was also found over the period of 4 months. Mastectomy was performed on the left caudal mammary gland and castration was also performed. After the final surgery, the dog fully recovered. Histopathological examination of all three masses revealed high grade mammary adenocarcinoma in the mammary gland and the testis was diagnosed as Leydig cell adenoma. Immunohistochemical analysis revealed that the estrogen and progesterone receptors were expressed on limited cells in mammary and testis tumors. Conclusion The results of this study suggest that mammary tumors and testes tumors can occur in male dogs without relationship to female sexual hormone