Synthesis and Antimicrobial Activity of Some 2-Amino-4-(7- Substituted/Unsubstituted Coumarin-3-yl)-6-(Chlorosubstitutedphenyl) Pyrimidines

Purpose: To prepare some 2-amino 4- (7-substituted/unsubstitutedcoumarin-3-yl)-6-(chlorosubstitute dphenyl) pyrimidines as antimicrobial agents.Methods: Some 2-amino-4-(7-substituted/unsubstitutedcoumarin-3-yl)-6-(chlorosubstitutedphenyl) pyrimidines were prepared by reacting 3-chlorosubstitutedphenyl-1-(7-substituted/unsubstituted coumarin 3-yl)prop-2-ene-1-ones with guanidine carbonate. The chemical structures of the synthesized compounds were elucidated by Fourier transform infra-red spectroscopy (FTIR), 1H-nuclear magnetic resonance (1H-NMR), mass spectrometry and elemental analysis. The synthesized compounds were investigated for their antimicrobial activity against four bacteria and five fungi by serial plate dilution method using ofloxacin and ketoconazole as reference antimicrobial drugs, respectively, and their minimum inhibitory concentrations (MICs) were determined.Results: Compounds 1 (p < 0.0001), 2 (p < 0.0001), 6 (p < 0.0001) and 8 (p < 0.0001) were the most active antibacterial agents among the synthesized compounds compared to control and standard agents. Structure-activity relationship revealed that substitution of chlorine atoms at 2- and 6- positions of the phenyl ring are critical for antibacterial activity in the case of dichlorophenyl derivatives, while for monochlorophenyl derivatives, the positions 2 and 4 of the phenyl ring were critical for antibacterial activity. None of the compounds exhibited comparable antifungal activity to the standard antifungal drug, ketoconazole, even at high concentrations.Conclusion: It is evident that the synthesized compounds are relatively very active antibacterial agents but are weak antifungal agents. However, these compounds need further evaluation of their antibacterial activity against other bacterial strains to ascertain their broad spectrum antibacterial activity.Keywords: Pyrimidine, Coumarin, Antibacterial, Antifungal, Structure-activity Relationshi

Genetic Improvement of Chickpea through Induced Mutation

Following seed treatment by two mutagens (HZ and MMS), four chickpea mutant lines were evaluated to find out selection response in M3 generation. Estimates of variability for yield and yield components were recorded higher. In comparison with the control plants, nitrate reductase activity (NRA) in leaf tissues of all the mutant lines was increased. The early maturity mutant lines showed the highest seed protein content and NRA

Evaluation of Wear Properties of Flyash and C-Glass Reinforced Al4046 Hybrid MMC

Metal Matrix Composites (MMCs) are engineered materials designed by a combination of a particulate or fibre reinforced in a metal or alloy matrix. This research work is concerned about the production of Fly ash, C-glass reinforced hybrid Aluminium 4046 metal matrix composites and further to investigate on the wear properties of the processed composites. Aluminium4046-Flyash-C-glass metal matrix composites have been processed for this study. In this work, the experimental study began with mixing of Aluminium powder, Fly ash particulates and C-glass fibers using a Stir casting technique at different weight fraction addition of Fly ash(2%,4%,6%) and Cglass(1%,3%,5%,7%).After production, the machining of the hybrid metal matrix composites is carried out as per ASTM standards. The wear rate is calculated using Pin on disc test machine. This experiment result show that best wear resistant combination is at 6% of Fly ash and 7% of C-glass is used

Building a Text Collection for Urdu Information Retrieval

Urdu is a widely spoken language in the Indian subcontinent with over 300 million speakers worldwide. However, linguistic advancements in Urdu are rare compared to those in other European and Asian languages. Therefore, by following Text Retrieval Conference standards, we attempted to construct an extensive text collection of 85 304 documents from diverse categories covering over 52 topics with relevance judgment sets at 100 pool depth. We also present several applications to demonstrate the effectiveness of our collection. Although this collection is primarily intended for text retrieval, it can also be used for named entity recognition, text summarization, and other linguistic applications with suitable modifications. Ours is the most extensive existing collection for the Urdu language, and it will be freely available for future research and academic education

Study on serum iron profile in COVID-19 associated mucormycosis patients

Background: Mucormycosis is an angio-invasive disease caused by fungi prevalence of which in India is approximately 0.14 cases per 1000 population. The incidence of mucor in COVID 19 patients has increased to greater extent. Probable cause of which is increased serum ferritin among these patients and Iron is required by virtually all microbial pathogens for growth and virulence. Hence, we had conducted a study to estimate serum iron profile and association of iron profile with mucor mycosis in covid-19 associated mucormycosis.Methods: Cross sectional study conducted from May 2021 to July 2021 by the department of general medicine, Banglore medical college and research centre, Karnataka. The data collected was analyzed statistically using descriptive statistics.Results: We observed increased prevalence of mucor cases among the patients aged between 41 to 60 years and those who were not vaccinated. Hyperglycaemia had strong correlation with development of mucor. There was lower UIBC, lower TIBC, high ferritin and serum Iron levels among those who had developed mucormycosis.Conclusions: By our observations, we concluded that the increased serum iron, ferritin, transferrin and reduced TIBC and UIBC are the associated risk factor in the development of COVID 19 associated invasive mucor mycosis. Patients with HbA1c >7 are at higher risk of developing COVID 19 associated mucor mycosis

The Moderating Effect of Time Pressure on Packaging Elements and Consumer Buying Behavior: A case of Nestle Pakistan

The purpose of this study to measure whether three product packaging Elements Wrapper Design, Packaging Material and Printed Information Influences Consumer Buying Behavior or does Time Pressure shows a moderating relationship. This study determines the importance of these elements when they purchase Nestle products during short time period. In this research highlighted that companies cannot afford to ignore the importance of time constraints and packaging elements of the products on consumer Buying Behavior. The study was conduct in District Vehari, Punjab Pakistan. Data was collecting to the students of Higher Educational Institution in District Vehari. Structured Questionnaire was used that consist on five point Likert Scale. Multiple Regression Analysis, ANOVA, coefficient was used to test the variables

Netted radar modelling, design and optimisation

Networks of phased array radars are able to provide better counter stealth target detection and classification. Each radar sensor/node generates information which requires transmission to a central control authority who is able to evaluate the information. This requires a communications network to be established to allow transmission of information to and from any node. Each radar node is limited by range and degree and relies on the formation of a multi-hop network to facilitate this transmission. This thesis investigates a method whereby the radar beam itself is used in the formation of a multi-hop network. The phased array's multifunctional nature allows rapid switching between communications and radar function. A complete model of how the communication system could operate is included in this thesis. In order to simulate radar function and network communication, a custom built simulation platform was used. Two different approaches to the formation of the radar networks are derived, one involving a global design method using the Strength Pareto Evolutionary Algorithm (SPEA) and another using a local method specifically tailored to radar network formation, Distributed Algorithm for Radar Topology Control (DARTC). Both of these techniques can be used in the formation of radar networks. The thesis goes further to suggest modifications to the model itself that could result in improved radar network communication performance.EThOS - Electronic Theses Online ServiceGBUnited Kingdo