Une route Lyon-Bordeaux à travers les monts d'Auvergne, antérieure au XVIIIe siècle

Imberdis F. Une route Lyon-Bordeaux à travers les monts d'Auvergne, antérieure au XVIIIe siècle. In: Revue de géographie alpine, tome 16, n°1, 1928. pp. 169-177

Bacs et ponts sur le cours auvergnat de l'Allier au XVIIIe siècle

Imberdis F. Bacs et ponts sur le cours auvergnat de l'Allier au XVIIIe siècle. In: Revue de géographie alpine, tome 17, n°3, 1929. pp. 611-636

Les plans cadastraux au service de l'étude des voies de communications et du développement urbain

Imberdis F. Les plans cadastraux au service de l'étude des voies de communications et du développement urbain. In: Annales d'histoire économique et sociale. 4ᵉ année, N. 16, 1932. pp. 368-370

Le problème des champs courbes

Imberdis F. Le problème des champs courbes. In: Annales. Economies, sociétés, civilisations. 6ᵉ année, N. 1, 1951. pp. 77-81

Les routes médiévales : mythes et réalités historiques

Imberdis F. Les routes médiévales : mythes et réalités historiques. In: Annales d'histoire sociale. 1ᵉ année, N. 4, 1939. pp. 411-416

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

In Parkinson's disease (PD), α-synuclein (αS) pathologically impacts the brain, a highly lipid-rich organ. We investigated how alterations in αS or lipid/fatty acid homeostasis affect each other. Lipidomic profiling of human αS-expressing yeast revealed increases in oleic acid (OA, 18:1), diglycerides, and triglycerides. These findings were recapitulated in rodent and human neuronal models of αS dyshomeostasis (overexpression; patient-derived triplication or E46K mutation; E46K mice). Preventing lipid droplet formation or augmenting OA increased αS yeast toxicity; suppressing the OA-generating enzyme stearoyl-CoA-desaturase (SCD) was protective. Genetic or pharmacological SCD inhibition ameliorated toxicity in αS-overexpressing rat neurons. In a C. elegans model, SCD knockout prevented αS-induced dopaminergic degeneration. Conversely, we observed detrimental effects of OA on αS homeostasis: in human neural cells, excess OA caused αS inclusion formation, which was reversed by SCD inhibition. Thus, monounsaturated fatty acid metabolism is pivotal for αS-induced neurotoxicity, and inhibiting SCD represents a novel PD therapeutic approach. Keywords: Parkinson’s disease; synucleinopathy; alpha-synuclein; stearoyl-CoA-desaturase; unsaturated fatty acid; oleic acid; lipid droplets; diglyceride; triglyceride; tetramer; inclusion