82 research outputs found
Attenuation of pressor responses to norepinephrine and pitressin and potentiation of pressor response to angiotensin II by captopril in human subjects
Elevated Neuropeptide Y Plasma Concentration in Non-dippers With Essential Hypertension
WstÄp Brak nocnego obniĆŒenia ciĆnienia tÄtniczego prowadzi do zwiÄkszonej czÄstoĆci powikĆaĆ narzÄ
dowych nadciĆnienia tÄtniczego, a jego przyczyny pozostajÄ
niejasne. Celem pracy byĆa ocena zaleĆŒnoĆci miÄdzy biochemicznymi wykĆadnikami
aktywnoĆci wspĂłĆczulnej a rytmem dobowym ciĆnienia u chorych z pierwotnym nadciĆnieniem tÄtniczym.
MateriaĆ i metody Do badania zakwalifikowano 68 chorych z nadciĆnieniem tÄtniczym w Ćrednim wieku 40 ± 1 lat (20 K, 48 M). Do grupy kontrolnej wĆÄ
czono 25 zdrowych ochotnikĂłw w Ćrednim wieku 38 ± 1 lat (8 K i 17 M). U badanych wykonywano
24-godzinny pomiar ciĆnienia (SpaceLabs 90207) oraz oznaczano we krwi stÄĆŒenie katecholamin i neuropeptydu Y. CaĆodobowo prowadzono zbiĂłrkÄ moczu w celu oznaczenia
wydalania katecholamin.
Wyniki U chorych z nadciĆnieniem tÄtniczym stÄĆŒenie neuropeptydu Y byĆo
wyĆŒsze niĆŒ u osĂłb zdrowych. StÄĆŒenie katecholamin w surowicy i ich wydalanie z moczem byĆy w obu grupach podobne. Chorych z nadciĆnieniem podzielono na dwie grupy zaleĆŒnie od obecnoĆci - dippers (46 chorych) - lub braku nocnego obniĆŒenia ciĆnienia - non-dippers (22 chorych). StÄĆŒenie neuropeptydu Y byĆo istotnie wyĆŒsze w grupie non-dippers niĆŒ w grupie dippers (10,6 ± 1 vs. 8,6 ± 1 fmol/ml, p < 0,05). Nie stwierdzono miÄdzy grupami rĂłĆŒnic w zakresie stÄĆŒenia katecholamin w surowicy i katecholamin wydalanych z moczem. W obu grupach wydalanie katecholamin w czasie nocy byĆo istotnie niĆŒsze aniĆŒeli w ciÄ
gu dnia. Nocne i dzienne wydalanie katecholamin byĆo podobne w grupie dippers i non-dippers.
Wnioski Uzyskane wyniki wskazujÄ
, ĆŒe neuropeptyd Y moĆŒe wpĆywaÄ na zaburzenie rytmu dobowego ciĆnienia tÄtniczego u chorych z nadciĆnieniem i brakiem nocnego obniĆŒenia ciĆnienia. Prawdopodobnie katecholaminy nie wpĆywajÄ
na dobowy rytm ciĆnienia tÄtniczego.Background The aim of the study was to investigate the relationship between biochemical indices of sympathetic activity and diurnal blood pressure rhythm in patients with essential hypertension.
Material and methods The study included 68 patients with mild-to-moderate essential hypertension (EH) (mean age 40 ± 1 yrs; 20 F, 48 M). The control group consisted of 25 healthy normotensive volunteers (C) (mean age 38 ± 1 yrs; 8 F, 17 M). Twenty-four hour ambulatory blood pressure monitoring was obtained using the SpaceLabs 90207. Blood samples for NPY and catecholamines were taken. Urine for catecholamines determination was collected.
Results In patients with EH NPY, plasma concentration was significantly higher as compared to C. Plasma catecholamine and urine catecholamine excretion was similar in patients with EH and in C. Patients with EH were divided into two groups: dippers (46 pts) and non-dippers (22 pts). In EH, the NPY plasma concentration was significantly higher in non-dippers than in dippers (10,6 ± 1 vs. 8,6 ± 1 fmol/mL, respectively, p < 0,05). No differences in plasma catecholamine and urine catecholamine excretion were found between dippers and non-dippers. Urine catecholamine excretion during nighttime was significantly lower as compared to day-time excretion in dippers and non-dippers. No differences between the groups were found with regard to day-time and night-time catecholamine excretion.
Conclusion NPY may play a role in diurnal blood pressure rhythm disturbances in non-dippers with EH. Catecholamines appear not to influence non-dipper phenomenon
Ambulatory Blood Pressure and 10-Year Risk of Cardiovascular and Noncardiovascular Mortality The Ohasama Study
Response to âDeath or hospitalization of patients on chronic hemodialysis is associated with a physician-based diagnosis of depressionâ
Hypotensive and bradycardic effects of centrally administered vasopressin in stroke-prone spontaneously hypertensive rats
The influence of varying dietary sodium content on circadian blood pressure profile in patients with salt-sensitive hypertension
The pathogenesis of essential hypertension is not fully understood. Literature indicates the complexity of blood pressure regulating mechanisms with a high impact of genetics and environmental factors. Previous experimental studies have shown the importance of salt intake in the development of hypertension. The aim of the study was to explore the influence of varying dietary sodium content on circadian blood pressure profile in patients with salt-sensitive hypertension. The study was carried out among 69 salt-sensitive hypertensive patients (19 females i 50 males) mean aged 36.1 ± 8.0 years. Study protocol provided low sodium diet firstly then high sodium diet containing 10â20 mmol and 220â240 mmol of sodium per day respectively. On each of the diet ABPM was performed. Our results suggest that in salt-sensitive patients the reduction of salt intake may decrease blood pressure and restore its circadian profile and thus lead to the reduction in the rate of complications of hypertension
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