228 research outputs found
DIFFERENCE SCHEME OF SOLITON EQUATIONS(State of art and perspectives of studies on nonlinear integrable systems)
Pctaire1/Cdk16 promotes skeletal myogenesis by inducing myoblast migration and fusion
AbstractThe Cdk-related protein kinase Pctaire1/Cdk16 is abundantly expressed in brain, testis and skeletal muscle. Functional roles of Pctaire1 such as regulation of neuron migration and neurite outgrowth thus far have been mainly elucidated in the field of nervous system development. Although these regulations based on cytoskeletal rearrangements evoke a possible role of Pctaire1 in the development of skeletal muscle, little is known in this regard. In this study, we demonstrated that myogenic differentiation and subsequent fusion is promoted in Pctaire1 overexpressing cells, and conversely, is inhibited in the knockdown cells. Furthermore, our findings suggest that Pctaire1 exerts promyogenic effects by regulating myoblast migration and process formation during skeletal myogenesis
Are one’s attachment avoidance toward a particular person and his/her placement of this particular person in the attachment hierarchy inversely overlapping? Four bifactor-analysis studies
Do one’s hierarchical preference for attachment support from a particular person over other people (attachment hierarchy) and his/her discomfort with closeness and uneasiness about being dependent on that particular person (attachment avoidance) inversely overlap? These two constructs have been distinctly conceptualized. Attachment hierarchy has been regarded as a normative characteristic of attachment relationships, while attachment avoidance has been considered to reflect an individual difference of relationship quality. Employing bifactor analyses, we demonstrated a unidimensional general factor of these two concepts in four studies exploring Czech young adults’ relationships with mother, father, friends, and romantic partner (Study 1); U.S. young adults’ relationships with a romantic partner (Study 2); Czech adolescents’ relationships with mother, father, and friends (Study 3); and Japanese young adults’ relationships with mother, father, and romantic partner (Study 4). These convergent results provide the replicable and generalizable evidence that one’s attachment avoidance toward a particular person and her/his placement of that particular person in the attachment hierarchy are inversely overlapping
A Proposal of an Axial-Flux Permanent-Magnet Machine Employing SMC Core With Tooth-Tips Constructed by One-Pressing Process: Improving Torque and Manufacturability
This study aims to improve the torque performance and manufacturability of axial-flux permanent magnet (AFPM) machines. Hence, we propose a novel AFPM machine that employs a soft magnetic composite (SMC) core with tooth-tips constructed by a one-pressing process and die. In this paper, the proposed AFPM machine is compared to two conventional AFPM machines using an SMC core. One of them has open-slot structure without tooth-tips. Another model employs an SMC core with tooth-tips pressed by a conventional pressing process that requires multiple operations and dies. As a result of the comparison, the proposed AFPM machine realizes a much higher torque than the two conventional machines. Additionally, the manufacturability of an SMC core with tooth-tips pressed by the proposed method is superior to the conventional one because the proposed structure can be realized by the one-pressing process and die. Furthermore, two prototypes of the proposed AFPM machine and the conventional one with an open-slot structure are fabricated, and then, they are compared by experiments. Consequently, the proposed AFPM machine achieves a 15.7% higher torque than that of the conventional machine using an open-slot structure. Finally, this paper presents an improved design of an AFPM machine with SMC cores using the proposed pressing process. As a result, the proposed AFPM realizes a 20% larger torque than that of a conventional model employing an open-slot structure
The BcsD subunit of type I bacterial cellulose synthase interacts dynamically with the BcsAB catalytic core complex
Cellulose synthase has two distinct functions: synthesis of the cellulose molecule (polymerization) and assembling the synthesized cellulose chains into the crystalline microfibril (crystallization). In the type I bacterial cellulose synthase (Bcs) complex, four major subunits --BcsA, BcsB, BcsC and BcsD-- work in a coordinated manner. This study showed that the crystallization subunit BcsD interacts with the polymerization complex BcsAB in two modes: direct protein–protein interactions and indirect interactions through the product cellulose. We hypothesized that the former and latter modes represent the basal and active states of type I bacterial cellulose synthase, respectively, and this dynamic behaviour of the BcsD protein regulates the crystallization process of cellulose chains
An O(n 1 2 +ɛ)-Space and Polynomial-Time Algorithm for Directed Planar Reachability
Abstract—We show that the reachability problem over directed planar graphs can be solved simultaneously in polynomial time and approximately O ( √ n) space. In contrast, the best space bound known for the reachability problem on general directed graphs with polynomial running time is O(n/2 √ log n Keywords-reachability, directed planar graph, sublinear space, polynomial time I
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