Synthesis, Structure of Nitrogen-Containing Phosphinogold(I) Ferrocenes. In vitro Activity against Bladder and Colon Carcinoma Cell Lines

The gold salt [(tht)AuCl] was reacted with [1-N,N-dimethylaminométhyl-2-diphenylphosphino]ferrocene (1) forming the bimetallic derivative 4. The reaction of methyl iodide and tetramethylammonium bromide on the chloride 4 produced the ammonium salt 5 and the bromide 6 respectively. New aminophosphines 2 and 3, which represent two of the rare phosphorylated metallocenes containing P(III)-N bond have also been coordinated to gold(I) to form 7 and 8. The presence of the ethoxy group in 7 provides evidence for the lability of one nitrogen-phosphorus bond. The X-ray structure of compounds 4 and 7 have been established. Both crystallize in space group P21/c, monoclinic, with a = 11.095(2) Å, b = 12.030(3) Å, c = 17.763(4) Å, β= 94.02(2)∘, Z = 4 for 4 and a = 14.863(3) Å, b = 8.036(5)Å, c = 18.062(5)Å, β =101.64(1)°, Z = 4 for 7. 197Au Mössbauer data are in good agreement with those for other linear P-Au-Cl containing complexes. The compounds were evaluated for in vitro anti-tumour activity against two human tumours. Differential cytotoxicity was observed with activity comparable to cisplatin, with the exception of one compound which was significantly more cytotoxic

Crystal structure of bis(μ2-triphenylacetato-κO:κO′)bis(diisobutylaluminium)

Single crystals of the title compound, [Al(iBu)2(O2CCPh3)]2 or [Al2(C4H9)4(C20H15O2)2], have been formed in the reaction between tris(tetrahydrofuran)tris(triphenylacetato)neodymium, [Nd(Ph3CCOO)3(THF)3], and triisobutylaluminium, Al(iBu)3, in hexane followed by low-temperature crystallization (243 K) from the reaction mixture. The structure has triclinic (P\overline{1}) symmetry at 120 K. The dimeric complex [Al(iBu)2(O2CCPh3-μ-κO:κO′)]2 is located about an inversion centre. The triphenylacetate ligand displays a μ-κO:κO′-bridging coordination mode, leading to the formation of an octagonal Al2O4C2 core. The complex displays HPh...CPh intermolecular interactions

Crystal structure and catalytic activity of tetrakis(μ2-ethyl 2,6-di-tert-butyl-4-methylphenyl phosphato-κ2O:O′)bis(ethyl 2,6-di-tert-butyl-4-methylphenyl phosphato-κ2O,O′)dilutetium n-heptane disolvate

The title complex, [Lu2(C17H28O4P)6]·2C7H16, was formed in the reaction between potassium 2,6-di-tert-butyl-4-methylphenyl ethyl phosphate, [K(2,6-tBu2-4-MeC6H2-O)(EtO)PO2], and LuCl3(H2O)6 in water, followed by vacuum drying and recrystallization from heptane. Its crystal structure has triclinic (P\overline{1}) symmetry at 120 K. The lutetium tris(phosphate) complex has a binuclear [Lu2(μ-OPO)4] core and the organophosphate ligand exhibits κ2O,O′ terminal and μ2-κ1O:κ1O′ bridging coordination modes with the LuIII ion being sixfold coordinated. The complex is of interest as a precatalyst in the acrylonitrile polymerization process and displays good catalytic activity under mild conditions

Crystal structure of bis(μ2-methanolato-κO:κO)hexamethylbis(μ2-triphenylacetato-κO:κO′)bis(μ2-triphenylacetato-κ2O,O′:κO)dialuminiumdilanthanum toluene tetrasolvate

The title compound, [Al2La2(C20H15O2)4(CH3)6(CH3O)2]·4CH3C6H5 or [{La(Ph3CCOO)2(Me3AlOMe)}2]·4CH3C6H5, was formed in a reaction between lanthanum tris(tetramethylaluminate) and triphenylacetic acid (1:1) with unintended partial oxidation. The triphenylacetate ligand exhibits μ2-κ1O:κ1O′ bridging and μ2-κ2O,O′:κ1O semi-bridging coordination modes, forming a dimeric La2(μ-OCO)4 core. The semi-bridging triphenylacetate group provides additional bonding with an La3+ cation via the π-system of one of its phenyl rings. The trimethylmethoxyaluminate anion, which is coordinated to the La3+ cation by its O atom, displays a rather long La—CMe bond. Two toluene molecules are each disordered over two orientations about centres of symmetry with site occupancy factors of 0.5. The title compound represents the first example of an LnIII complex containing both alkyl alkoxide aluminate and π-bounded arene fragments