3 research outputs found
Paracrine osteoprotegerin and β-catenin stabilization support synovial sarcomagenesis in periosteal cells
Permeabilization of the Blood-Brain Barrier via Mucosal Engrafting: Implications for Drug Delivery to the Brain
The (not so) controversial role of DNA methylation in epigenetic inheritance across generations.
It has been demonstrated originally in plants that phenotypic traits,
such as floral symmetry, can be caused by changes of methylation
patterns of specific genes. Such traits can be transgenerationally
inherited for multiple generations and remain associated with cytosine
methylation patterns. Whether genomic methylation may also contribute to
epigenetic inheritance across generations in vertebrates and notably in
mammals is still more controversial. One reason for this tentativeness
is the dual occurrence of global genomic de-methylation first in
pre-implantation embryos and subsequently in primordial germ cells
(PGCs) of mammals. Although gene focused cases of epigenetic inheritance
associated with genomic DNA methylation have been well studied mostly
in rodents (such as imprinted genes and the Agouti viable yellow, Avy,
allele), it is still a matter of debate whether genomic DNA methylation
may provide a more general mechanism for the epigenetic inheritance of
acquired traits across generations. We review the current literature on
this topic with a focus on the potential role of DNA methylation for
epigenetic inheritance across generations in mammals