Synthesis and characterization of novel four heterodimetallic mixed metal complexes of 2,6-pyridinedicarboxylic acid

Four novel hetero dimetallic mixed metal complexes of 2,6-pyridinedicarboxylic acid       (H2dipic), [Ni(H2O)5Co(dipic)2] (1), [Co(H2O)5Co(dipic)2][Ni(H2O)5Ni(dipic)2][Co(dipic)(H2O)3] (2), [Cu(H2O)5Ni(dipic)2]2[Co(dipic)(H2O)] (3) and [Ni(H2O)5Cu(dipic)2]2[Co(dipic)(H2O)] (4) have been prepared and characterized by elemental, AAS, spectral (IR and UV-Vis), and thermal analyses, as well as by using magnetic measurement and molar conductivity techniques. The results indicate that metal ions coordinate with 2,6-pyridinedicarboxylate ions (dipic2-) nitrogen atoms and carboxylate oxygen atoms of ligands. The mole ratio of dipic2- and metal ions in the complexes have been determined to be 2:2 (Co, Ni) for 1, 5:5 (3Co, 2Ni) for 2, 5:5 (Co, 2Ni and 2Cu) for 3 and 5:5 (Co, 2Ni and 2Cu) for 4 according to the results of elemental analysis. The structures of 1-4 might be proposed as octahedral ([Cu(dipic)(H2O)] unit for 2 square plane) according to results of spectroscopic analysis. The TG and DTA properties of compounds have been studied.                     KEY WORDS: 2,6-Pyridinedicarboxylic acid, Mixed metal, Metal complex   Bull. Chem. Soc. Ethiop. 2020, 34(2), 313-321 DOI: https://dx.doi.org/10.4314/bcse.v34i2.

2-aminobenzotiyazolün karışık ligandlı metal kompleksleri ve biyolojik özellikleri hakkında literatür çalışması

2-Aminobenzotiyazol ile bazı organik bileşiklerin [β-pikolin, γ-pikolin, isokinolin, asetilaseton, o-hidroksiasetofenon, 1,2-etilendiamin, piperazin, N, N'-bis(4-antipirilmetil)piperazin, N,N'-tetra(4-antipirilmetil)-1,2-diaminoetan, N,N'-bis(4-antipirilmetil) piperazin, N, N'-tetra(4-antipirilmetil)-1,2-diaminoetan, ftalamid, malonamid, benzilaseton, tetrametilen sulfoksit, katekol, p-klorofenoksiasetik asit, 7-oksobisiklo[2.2.1] heptan-2,3-dikarboksilik asit, 2,2’-bipridin, 1.10-fenantrolin, propanoik asit, fenoksiasetik, 2-imino-3-allilbenzotiyazol, sakarin, trifenilfosfin, trifloroasetik asit, adipik asit, 1,4-benzendikarboksilik asit, süksinik asit, formik asit, pikrik asit, amino asit, p-formilfenoksiasetik asit ve 2,6-piridindikarboksilik asit] karışık ligandlı metal komplekslerinin (M = Mn, Fe, Co, Ni, Cu, Zn, Ag, Au, Ru, Os, Ir, Pd, Rh, U, Eu ve Tb) yapıları ve biyolojik özelliklerini anlatan çalışmalar literatürde gözlenmiştir. Bu bileşiklerde 2-aminobenzotiyazol metale tiyazol halkasının N ve/veya S ve/veya animo grubundan bağlanmakta ya da tamamlayıcı iyon şeklinde yapıda yer almaktadır. Bu komplekslerinin antibakteriyel, antikanser, antifungal, anti-inflamatuar, antitümör ve karbonik anhidraz inhibisyonu gibi biyolojik özellikleri bilinmektedir

Polinom regresyonuyla olası ekstrem aylık ortalama hava sıcaklığı tahmini

19. yüzyılın sonlarından bu yana küresel ısınmada yaşanan artış, ekstrem sıcaklık olaylarının gözlenme süresini arttırmış, sıcak hava dalgalarının frekans ve yoğunluğunun artmasına neden olmuştur. Sıcaklıkta görülen bu değişimler iklim sistemlerinde ve hidrolojik döngüde değişikliklere sebep olmuştur. Bu değişiklikler afetlere ve ekonomik zararların oluşmasına sebep olmaktadır. Bu nedenle sıcaklığın davranışını tahmin edebilmek önemli bir konu haline gelmiştir. Bu çalışmada, Türkiye’deki meteoroloji istasyonlarındaki gözlenen hava sıcaklığı verilerindeki eksik kısımlar SPSS programı kullanılarak, beklenti maksimizasyonu yardımıyla tamamlanmıştır. Daha sonra polinom regresyonunu kullanan bir yazılım olan PolReg ile gelecekte gerçekleşmesi muhtemel ekstrem aylık ortalama hava sıcaklıkları, %95 güven aralığı sınırları içerisinde yılın her ayı için tahmin edilmiştir. Böylece, Türkiye genelinde hava sıcaklıklarının hangi bölgede hangi değerlere kadar yükselebileceği konusunda öngörü oluşturulması amaçlanmıştır. Türkiye’nin çeşitli yerlerindeki 82 adet meteoroloji gözlem istasyonun ortalama hava sıcaklık değerleri kullanılarak yıldaki 12 ay için beklenen muhtemel maksimum değerler tahmin edildikten sonra bu tahminler, ArcMap programında ters mesafe ağırlıklı yöntem ile her ay için Türkiye ekstrem aylık ortalama hava sıcaklığı haritaları oluşturulmuştur.Increase in global warming since the end of the 19. century has increased the duration of extreme temperature events and caused the frequency and intensity of heat waves to increase. These changes in temperature have caused changes in climate systems and the hydrological cycle. These changes cause disasters and economic losses. Therefore, being able to predict the behavior of temperature has become an important issue. In this study, the missing parts of the observed air temperature data at meteorological stations in Turkey were completed using the SPSS program with the help of expectation maximization. Then, with PolReg, a software using polynomial regression, the extreme monthly average air temperatures that are likely to occur in the future were predicted for each month of the year within the limits of the 95% confidence interval. Thus, it is aimed to create a prediction about which values the air temperatures may rise to in which region throughout Turkey. After predicting the expected possible maximum values for 12 months of the year using the average air temperature values of 82 meteorological observation stations in various parts of Turkey, these predictions were created in the ArcMap program using the inverse distance weighted method for each month of Turkey's extreme monthly average air temperature maps

Salisilik asit türevleri ile 2-aminobenzotiyazol türevlerinin karışık ligandlı Cu(II) komplekslerinin sentezi ve karakterizasyonu

Bu çalışmada, salisilik asit türevleri [salisilik asit (H2sal) veya asetilsalisilik asit (Hasal)] ile 2-aminobenzotiyazol türevlerinin [2-aminobenzotiyazol (abt) veya 2-amino-6-klorobenzotiyazol (Clabt) veya 2-amino-6-metilbenzotiyazol (Meabt)] karışık ligandlı Cu(II) geçiş metal kompleksleri sentezlenmiştir. Amorf halde elde edilen geçiş metal komplekslerinin yapıları elementel analiz, ICP-OES, FT-IR, UV-Vis, termal analiz, manyetik duyarlılık ve molar iletkenlik sonuçları dikkate alınarak önerilmiştir

Denizli, Turkey

Gokpinar spring is one of the most important drinking water resources of Denizli city (Turkey), covering more than one third of the water need of the municipality. In this paper, we present a combination of geophysical methods in order to define the groundwater flow paths in Gokpinar spring region. The spring of Gokpinar is a result of the Fault-fracture network formed during the tectonic events which took place in the study area. This fault and fracture system present in the Gokpinar spring zone are characterized by the Cankurtaran fault in the east and Babadag fault in the south. To highlight the main directions of the groundwater flows feeding Gokpinar spring, an electrical resistivity tomography (ERT) survey was carried out in the study area. The results obtained from this survey have been confirmed by a frequency domain electromagnetic (FEM) survey carried out along four profiles in addition to four ground penetrating radar profiles (GPR) profiles. The comparison of the two auxiliary methods with the ERT profiles allowed a better understanding of the groundwater movements. The ERT data was collected along six profiles corresponding to Wenner-Schlumberger array and located predominantly in the southern and eastern parts of the spring surrounding area. In order to confirm the hypothesis from the interpretation of the ERT profiles, two simplified different scenarios were numerically and experimentally considered. The results of the combined methods have ultimately led to define the main direction of groundwater flows feeding the Gokpinar spring, which is related to four factors: The Fault-Fracture network, karstic features, the topography, and deep groundwater.C1 [Oudeika, Mohamed Salem; Ilkimen, Elif Meric; Tasdelen, Suat] Pamukkale Univ, Dept Geol Engn, Denizli, Turkey.[Aydin, Ali] Pamukkale Univ, Dept Geophys Engn, Denizli, Turkey

plasma

The development of electrochemical sensors via surface modification has attracted considerable attention as a low-cost method to the sensitive detection of a variety of analytes. In addition, the surface modification of electrodes has been directed toward several goals, often involving electrode kinetics and chemical selectivity. In this study, we performed the electrochemical modification of glassy carbon (GC) electrode with 2-thiolbenzimidazole (2-TBI). The developed electrode was characterized by the reflection-absorption infrared spectroscopy (RAIRS), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM). According to the RAIRS results, the binding type of the 2-TBI to glassy carbon electrode was through the etheric linkage. The working range of the developed electrode was also studied. In addition, the developed electrode was applied to human plasma samples for the determination of Cd(II). The linearity range of Cd(II) was obtained as 1.0 x 10(-11)-2.5 x 10(-10) M with the detection limit (S/N = 3) of 2.40 x 10(-12) M. (C) 2014 Elsevier B.V. All rights reserved

Carbonic anhydrase inhibitory activities of novel proton transfer salts and their Cu(II) complexes

In this study, two new proton transfer salts of sulfonamide derivatives of maleic acid, namely (ClHabt)+(mabsmal)– (1) and (ClHabt)+(pabsmal)– (2), were obtained from 2-amino-6-chlorobenzo­thiazole (Clabt) and N-(3-sulfamoylphenyl)maleamide acid (Hmabsmal) and N-(4-sulfamoyl­phenyl)maleamide acid (Hpabsmal), respectively. Also, the Cu(II) complexes (3 and 4) of salts (1 and 2) and of Hmabsmal (5) were prepared. Compounds 1‒5 were characterized by elemental, NMR (1H and 13C), FTIR, and thermal analyses, as well as UV-Vis, magnetic moment, and molar conductivity measurements. Carbonic anhydrase isoenzymes (hCA I and II) were purified from human erythrocyte cells by affinity chromatography. The effects of the synthesized compounds on the hydratase and esterase activities of CA isoenzymes were studied in vitro. The results reveal that the synthesized compounds inhibit both esterase and hydratase activities of hCA I and hCA II. The inhibition constants of the compounds (Ki) were determined according to the esterase activity measurements. Ki values of 1‒5 are in the range of 0.06 ± 0.003 µM and 4.25 ± 0.100 µM for hCA I, and of 0.02 ± 0.001 µM and 3.21 ± 0.200 µM for hCA II