CD73-Mediated Immunosuppression Is Linked to a Specific Fibroblast Population That Paves the Way for New Therapy in Breast Cancer

Background: Cancer-associated fibroblasts (CAF) are heterogeneous with multiple functions in breast cancer. Recently, we identified a specific CAF subpopulation (referred to as CAF-S1), which promotes immunosuppression and immunotherapy resistance. Methods and Results: Here, by studying a large collection of human samples, we highlight the key function of CD73/NT5E in CAF-S1-mediated immunosuppression in breast cancer. We first reveal that CD73 protein level specifically accumulates in CAF-S1 in breast cancer patients. Interestingly, infiltration of regulatory T lymphocytes (Tregs) is significantly correlated with CD73 expression in stroma but not in epithelium, indicating that CD73 contributes to immunosuppression when expressed in CAF-S1 and not in tumor cells. By performing functional assays based on relevant systems using primary CAF-S1 isolated from patients, we demonstrate that CAF-S1 increase the content in both PD-1+ and CTLA-4+ Tregs. Importantly, the use of a blocking anti-CD73 antibody on CAF-S1 reduces CAF-S1-mediated immunosuppression by preventing expression of these immune checkpoints on Tregs. Conclusions: Our data support the potential clinical benefit of using both anti-CD73 and immune-checkpoint inhibitors in breast cancer patients for inhibiting CAF-S1-mediated immunosuppression and enhancing anti-tumor immune response

The I-ADOPT Interoperability Framework for FAIRer data descriptions of biodiversity

Biodiversity, the variation within and between species and ecosystems, is essential for human well-being and the equilibrium of the planet. It is critical for the sustainable development of human society and is an important global challenge. Biodiversity research has become increasingly data-intensive and it deals with heterogeneous and distributed data made available by global and regional initiatives, such as GBIF, ILTER, LifeWatch, BODC, PANGAEA, and TERN, that apply different data management practices. In particular, a variety of metadata and semantic resources have been produced by these initiatives to describe biodiversity observations, introducing interoperability issues across data management systems. To address these challenges, the InteroperAble Descriptions of Observable Property Terminology WG (I-ADOPT WG) was formed by a group of international terminology providers and data center managers in 2019 with the aim to build a common approach to describe what is observed, measured, calculated, or derived. Based on an extensive analysis of existing semantic representations of variables, the WG has recently published the I-ADOPT framework ontology to facilitate interoperability between existing semantic resources and support the provision of machine-readable variable descriptions whose components are mapped to FAIR vocabulary terms. The I-ADOPT framework ontology defines a set of high level semantic components that can be used to describe a variety of patterns commonly found in scientific observations. This contribution will focus on how the I-ADOPT framework can be applied to represent variables commonly used in the biodiversity domain.Comment: submitted to S4BioDiv 2021: 3rd International Workshop on Semantics for Biodiversity, September 15, 2021, Bozen, Ital

Anogenital distance is associated with genital measures and seminal parameters but not anthropometrics in a large cohort of young adult men

Is the anogenital distance (AGD) correlated to anthropometric, genital and sperm parameters in young adult men

ERASMUS+ Strategic Partnerships between UNESCO Global Geoparks, Schools, and Research Institutions: A Window of Opportunity for Geoheritage Enhancement and Geoscience Education

Since both the EU Erasmus+ program and UNESCO Global Geoparks aim at developing models of best practices, a shared playground for common activities can be found in high geodiversity and rich geoheritage areas to promote innovative education and professional perspectives in the ecological transition. Two consecutive Erasmus+ cooperative partnerships (GEOclimHOME and GEOclimHOME-PRO) involved schools, research institutions, and three European geoparks (Rokua, Finland; Sesia Val Grande, Italy; Chablais, France) for improved perception of climate and environmental changes and appraisal of geoheritage. The common pedagogical approach is presented in this review paper as well as the different methodological solutions for (1) understanding climate change and (2) recognising its natural and human factors, by environmental research and professional experiences. Activities were first addressed to explore the “secret” values of geoheritage for awareness on climate changes. Later, active/passive roles of humans toward the environment have been analysed, which are related to the UN sustainable development goals (SDGs). Results of educational activities demonstrated enhanced students’ awareness of social and environmental responsibility. Moreover, the actions highlighted new job opportunities, accomplishing the local and global needs of sustainable development, future skills, and lifestyles within geopark territories

ERASMUS+ Strategic Partnerships between UNESCO Global Geoparks, Schools, and Research Institutions: A Window of Opportunity for Geoheritage Enhancement and Geoscience Education

Since both the EU Erasmus+ program and UNESCO Global Geoparks aim at developing models of best practices, a shared playground for common activities can be found in high geodiversity and rich geoheritage areas to promote innovative education and professional perspectives in the ecological transition. Two consecutive Erasmus+ cooperative partnerships (GEOclimHOME and GEOclimHOME-PRO) involved schools, research institutions, and three European geoparks (Rokua, Finland; Sesia Val Grande, Italy; Chablais, France) for improved perception of climate and environmental changes and appraisal of geoheritage. The common pedagogical approach is presented in this review paper as well as the different methodological solutions for (1) understanding climate change and (2) recognising its natural and human factors, by environmental research and professional experiences. Activities were first addressed to explore the “secret” values of geoheritage for awareness on climate changes. Later, active/passive roles of humans toward the environment have been analysed, which are related to the UN sustainable development goals (SDGs). Results of educational activities demonstrated enhanced students’ awareness of social and environmental responsibility. Moreover, the actions highlighted new job opportunities, accomplishing the local and global needs of sustainable development, future skills, and lifestyles within geopark territories

miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers

Cancer-associated fibroblasts (CAFs) are an important part of the tumor microenvironment. Here the authors characterize four subsets of CAFs across human samples of ovarian cancer subtypes and show in the mesenchymal subtype a specific CAF-S1 population that attracts immunosuppressive Tregs via CXCL12β