“Tanto Tiempo”: conexiones en Hangares Museo Interactivo

“Tribuka. Descubriendo conexiones”, es una aplicación móvil impulsada por COLCIENCIAS y PICOLAB (Colombia) que busca integrar el sector museal con el tecnológico, fortaleciendo las redes entre los museos y sus públicos. Este trabajo presenta la primera experiencia con Tribuka en Argentina, desarrollada en el Museo Interactivo Hangares por el equipo de profesionales del Programa Mundo Nuevo (UNLP). Esta institución desempeña actividades de popularización de la ciencia y la tecnología, destinadas principalmente a escuelas y familias. Con la finalidad de extender y potenciar las experiencias de los visitantes construimos la Misión “Tanto Tiempo”, que aborda el tema del tiempo como construcción social y cultural, a partir de la conexión de distintos exhibidores del museo. La propuesta busca provocar la curiosidad, la duda, la reflexión y la imaginación. A partir de un trabajo interdisciplinario se creó una narrativa que invita a mirar lo cotidiano desde otras perspectivas, a través de una propuesta lúdica de disfrute y aprendizaje mediada por el uso y apropiación de las TICS.Universidad Nacional de La Plat

“Tanto Tiempo”: conexiones en Hangares Museo Interactivo

“Tribuka. Descubriendo conexiones”, es una aplicación móvil impulsada por COLCIENCIAS y PICOLAB (Colombia) que busca integrar el sector museal con el tecnológico, fortaleciendo las redes entre los museos y sus públicos. Este trabajo presenta la primera experiencia con Tribuka en Argentina, desarrollada en el Museo Interactivo Hangares por el equipo de profesionales del Programa Mundo Nuevo (UNLP). Esta institución desempeña actividades de popularización de la ciencia y la tecnología, destinadas principalmente a escuelas y familias. Con la finalidad de extender y potenciar las experiencias de los visitantes construimos la Misión “Tanto Tiempo”, que aborda el tema del tiempo como construcción social y cultural, a partir de la conexión de distintos exhibidores del museo. La propuesta busca provocar la curiosidad, la duda, la reflexión y la imaginación. A partir de un trabajo interdisciplinario se creó una narrativa que invita a mirar lo cotidiano desde otras perspectivas, a través de una propuesta lúdica de disfrute y aprendizaje mediada por el uso y apropiación de las TICS.Universidad Nacional de La Plat

Gamificación en el Museo Interactivo Hangares : Experiencias participativas para los visitantes

El presente trabajo tiene como finalidad reflexionar sobre el proceso y la toma de decisiones referidas al diseño y elaboración de la propuesta de gamificación “Tribuka. Descubriendo conexiones” desarrollada en Hangares Museo Interactivo en República de los Niños. Esta iniciativa estuvo a cargo del equipo de profesionales de Mundo Nuevo, Programa de popularización de las ciencias de la Universidad Nacional de La Plata. A partir de la invitación de los creadores de “Tribuka. Descubriendo conexiones” (COLCIENCIAS y PICOLAB, Colombia) se trabajó en la construcción de la primera experiencia con la aplicación móvil en el ámbito local. PICOLAB es una empresa que combina tecnología y contenidos digitales y cuenta con el apoyo del Departamento Administrativo de Ciencia, Tecnología e Innovación de Colciencias, Colombia. En este trabajo, analizaremos el proceso que implicó el diseño de la estrategia de gamificación y que posteriormente se materializó en una propuesta destinada a jóvenes y familias.Eje 2: Curaduría educativa y educación en museos.Red de Museos de la Universidad Nacional de La Plat

Analysis of appeals against the ruling of occupational physicians lodged with the Prevention and Occupational Epidemiology Operative Unit, ASP Palermo (Palermo Health Authority), from 2008-2010

Introduction: The responsibility of the Department for Prevention and Safety at the workplace of the Palermo Health Authority (ASP) is to monitor and coordinate the activity of occupational physicians operating in Palermo and its province. One of its obligations is to examine appeals “against the judgment of occupational physicians”, “...and, after carrying out further investigation, confirm, modify or reverse the ruling itself ” (art. 41, par. 6, legislative Decree 81/08). Objectives: The purpose of this study was to analyze the appeals lodged against a “judgment of fitness for work” submitted to the “Health Prevention and Occupational Epidemiology Operative Unit” of the Department of Prevention and Safety at the Workplace of the ASP Palermo, from 2008 to 2010. Methods: The total number of appeals lodged during the three-year period was 211, 174 of which were finalized. Results: The most frequent job category among the appellants was that of blue-collar workers, in various sectors, covering 44.5% of the subjects under study (93 cases). In 64.2% of the processed appeals (131 cases), the judgment of the physician was modified, while in the remaining 36.8% (73 cases) it was confirmed.The work fitness judgment with restrictions was the category against which most appeals were lodged, and the diseases in question mostly concerned the osteoarticular and cardiovascular systems. Conclusion: In a context of continuous change in the labour field and the related risks to the health and safety of workers, the occupational physician must approach the worker in a comprehensive manner,through an assessment of the possible health problems and the working environment in which he/she operates

“Tanto Tiempo”: conexiones en Hangares Museo Interactivo

“Tribuka. Descubriendo conexiones”, es una aplicación móvil impulsada por COLCIENCIAS y PICOLAB (Colombia) que busca integrar el sector museal con el tecnológico, fortaleciendo las redes entre los museos y sus públicos. Este trabajo presenta la primera experiencia con Tribuka en Argentina, desarrollada en el Museo Interactivo Hangares por el equipo de profesionales del Programa Mundo Nuevo (UNLP). Esta institución desempeña actividades de popularización de la ciencia y la tecnología, destinadas principalmente a escuelas y familias. Con la finalidad de extender y potenciar las experiencias de los visitantes construimos la Misión “Tanto Tiempo”, que aborda el tema del tiempo como construcción social y cultural, a partir de la conexión de distintos exhibidores del museo. La propuesta busca provocar la curiosidad, la duda, la reflexión y la imaginación. A partir de un trabajo interdisciplinario se creó una narrativa que invita a mirar lo cotidiano desde otras perspectivas, a través de una propuesta lúdica de disfrute y aprendizaje mediada por el uso y apropiación de las TICS.Universidad Nacional de La Plat

An Erythropoietin-Independent Mechanism of Erythrocytic Precursor Proliferation Underlies Hypoxia Tolerance in Sea Nomads

The Bajau Sea Nomads were recently demonstrated to have evolved larger spleens as an adaptation to millennia of a marine foraging lifestyle. The large-spleen phenotype appears to derive from increases in thyroid hormone (TH) production as a result of reduced expression of phosphodiesterase 10A (PDE10A), though the exact mechanism remains unknown. Through pharmacological inhibition of PDE10A using the selective inhibitor MP-10 in mice, we were able to mimic the Bajau adaptation and show that treated mice had significantly larger spleens than control animals. This difference appears connected to an excess of early stage erythrocytes and an apparent increase in red blood cell (RBC) precursor proliferation in response to increased TH. However, we determined that the stimulation of RBC production in the mouse model via TH is Erythropoietin (EPO)-independent, unlike in the altitude (chronic hypoxemia) response. We confirmed this using human GWAS data; although the Bajau PDE10A variants are significantly associated with increased TH levels and RBC count, they are not associated with EPO levels, nor are other strongly thyroid-associated SNPs. We therefore suggest that an EPO-independent mechanism of stimulating RBC precursor proliferation via TH upregulation underlies the increase in spleen size observed in Sea Nomad populations

The first horse herders and the impact of early Bronze Age steppe expansions into Asia

This is the author accepted manuscript. The final version is available from AAAS via the DOI in this recordThe file includes the article, supplementary material and additional supplementary materialThe published version of the supplementary materials are at http://science.sciencemag.org/content/suppl/2018/05/08/science.aar7711.DC1Part of the additional supplementary materials for this article are in ORE at http://hdl.handle.net/10871/32792The Yamnaya expansions from the western steppe into Europe and Asia during the Early Bronze Age (~3000 BCE) are believed to have brought with them Indo-European languages and possibly horse husbandry. We analyze 74 ancient whole-genome sequences from across Inner Asia and Anatolia and show that the Botai people associated with the earliest horse husbandry derived from a hunter-gatherer population deeply diverged from the Yamnaya. Our results also suggest distinct migrations bringing West Eurasian ancestry into South Asia before and after but not at the time of Yamnaya culture. We find no evidence of steppe ancestry in Bronze Age Anatolia from when Indo-European languages are attested there. Thus, in contrast to Europe, Early Bronze Age Yamnaya-related migrations had limited direct genetic impact in Asia.The study was supported by the Lundbeck Foundation (EW), the Danish National Research Foundation (EW), and KU2016 (EW). Research at the Sanger Institute was supported by the Wellcome Trust (grant 206194). RM was supported by an EMBO Long-Term Fellowship (ALTF 133-2017). JK was supported by the Human Frontiers Science Program (LT000402/2017). Botai fieldwork was supported by University of Exeter, Archeology Exploration Fund and Niobe Thompson, Clearwater Documentary. AB was supported by NIH grant 5T32GM007197-43. GK was funded by Riksbankens Jubileumsfond and European Research Council. MP was funded by Netherlands Organization for Scientific Research (NWO), project number 276-70-028, IU was funded by the Higher education commission of Pakistan. Archaeological materials from Sholpan and Grigorievka were obtained with partial financial support of the budget program of the Ministry of Education and Science of the Republic of Kazakhstan “Grant financing of scientific research for 2018-2020” No. AP05133498 “Early Bronze Age of the Upper Irtysh”

Population genomics of post-glacial western Eurasia.

Western Eurasia witnessed several large-scale human migrations during the Holocene <sup>1-5</sup> . Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes-mainly from the Mesolithic and Neolithic periods-from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a 'great divide' genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness decreased in the west from the Neolithic transition onwards, whereas, east of the Urals, relatedness remained high until around 4,000 BP, consistent with the persistence of localized groups of hunter-gatherers. The boundary dissolved when Yamnaya-related ancestry spread across western Eurasia around 5,000 BP, resulting in a second major turnover that reached most parts of Europe within a 1,000-year span. The genetic origin and fate of the Yamnaya have remained elusive, but we show that hunter-gatherers from the Middle Don region contributed ancestry to them. Yamnaya groups later admixed with individuals associated with the Globular Amphora culture before expanding into Europe. Similar turnovers occurred in western Siberia, where we report new genomic data from a 'Neolithic steppe' cline spanning the Siberian forest steppe to Lake Baikal. These prehistoric migrations had profound and lasting effects on the genetic diversity of Eurasian populations