VA.U.CITAMPARAM PIḶḶAI ORU PAṈMUKAP PĀRVAIYĀḶAR [C.V.CHIDAMBARAM PILLAI IS A MULTI-FACETED SPECTATOR]

This article shed light on V.C. Chidambaram Pillai's passion towards language and elaborates his multifaceted vision as a literary scholar, researcher, literary volunteer, teacher, literary revolutionist, and a great orator. The purpose of this article is to illustrate his diversity. The article corroborates, Chidambaram Pillai’s contribution to the development of Tamil language and Tamil people. The study has adopted the textual approach. This article also explains that no matter what circumstances prevail, V.C.Chidambaram Pillai has never failed to make his contribution to the Tamil language and Tamil community. The conclusion of this article is that wisdom helps to overcome any kind of situations.</jats:p

KEMAHIRAN KEPIMPINAN DALAM KARYA THIRUKKURAL [THE PRINCIPLES OF HUMAN RESOURCE MANAGEMENT IN THURUKKURAL]

The purpose of this study is to study the leadership skills in Thirukkural. The objective to strengthen this research is identify the characteristics of leadership skills in Thirukkural. Researchers have used qualitative methods to analyze the content in Thirukkural to collect research data. Researchers have conducted fieldwork by using Interactive Analysis Model and interview method to collect data on leadership skills in Thirukkural. The Thirukkural was written by Thiruvalluvar is excepted to exceed 2000 years ago. The findings of the study indicate that Thiruvalluvar has emphasized several features to strengthen leadership skills in student life through Thirukkural. The findings of this study provide effective implications from Thirukkural to overcome the challenges faced by a leader among the students.The conclusion of this study shows that the Thirukkural is excepted to exceed 2000 years ago, is still provides more effective exposure to leadership skills to leaders.</jats:p

Mapping the human genetic architecture of COVID-19

AbstractThe genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.</jats:p