Unethical Practices in Pakistani Construction Industry

Construction Industry plays a substantial role in a country’s national economy, regardless of the level of economic development. It is beyond any doubt that this sector is an important employer of a nation’s workforce as it employs between 2 to 10 percent of the total workforce in most of countries. Same is the case with Pakistani Construction Industry. The industry has never been explored and exploited to its fullest capacity. Unfortunately the industry is seriously infected with corrupt and unethical practices which lay major obstacles towards growth and productivity of the industry. This research has been undertaken with a view to find out the most occurring unethical practices in Pakistan. To achieve this objective, a survey questionnaire was designed and disseminated to the respondents. A total of 150 questionnaires were distributed, out of which total 125 responses were received, which is a good response for this study. The data was analyzed by using Statpro software. The major findings are; lack of training in ethics, corruption and bribery, bid shopping, and fraud and unfair conduct. These can be addressed by evolving codes of ethics, imparting high quality training in ethics and above all setting personal examples by the top management. Keywords: Unethical, Construction, Practices, Pakista

Trends of Safety Performance in Construction and Civil Engineering Projects in Pakistan

The major construction and  civil engineering projects are sponsored by public sector in Pakistan. The users contracting and bidding procedures do not offer a significant space to the aspect of safety performance in construction and engineering projects. The prevalent measures of safety are after- the- fact measures - that means safety is given importance once casualties have actually been occurred. Such practices or measures are termed as inductive, reactive, trailing, down stream or lagging indicators. This is so because they are based upon retrospective data. As the country has undergone through massive development in engineering, construction and infrastructure sectors, safety aspect has been transformed from lagging indicators to leading indicator. Companies and organizations have started focusing on good safety performance under safety climate and culture. In this paper, a sincere research effort has been made to assess and analyze the health and safety performance of various constructions firms as well as overall construction engineering industry of Pakistan. In order to achieve this objective, various structured interviews and survey questionnaire were designed. The data collected from industry specific respondents has been analyzed using statpro   software. The salient findings of this study are as follows; the majority of the casualties are Fall of Individuals from Heights, Electric Shocks, Caught in between the Plants, Machinery and Confined Spaces and Struck by an Object or Machinery. Similarly there is no positive mindset from top down, non application of safety laws, lack of safety management plan, lack of safety and health of workplace, inadequate arrangement of first aid, lack of personnel’s protective equipment and absence of accident reporting mechanism. The major recommendations of the study are as follows; At industry level, safety rules should be  as regulated and re-defined, documented and enforced. Moreover  provision of personnel protective equipment, training of entire organization, safety management plan under safety officer, adequate first aid at sites, efficient reporting mechanism and safety awareness of employees and workforce will also improve the existing situation. It is also recommended that more research should be carried out in order to evolve a comprehensive safety management policies. Keywords: Construction, civil engineering, Pakistan, safet

Cost Performance in Construction Industry of Pakistan

Construction industry is notorious and infamous as far as cost base lines and project budgets are concerned. More than 90 percent of projects delay gets over budgeted or completely abandoned due to either paucity of funds or mismanagement at different levels. Despite a major contributor in the Gross Domestic Product of a country, its full potential has never been exploited. Perhaps this retrogressive atmosphere has been cultivated by callous, careless and unprofessional attitudes of all stakeholders of construction industry. The primary stakeholders which affect the projects positively or negatively in cost dimension are; the government, the contractors, the consultants and the clients or owners. The authors conducted interviews as well as surveys with construction professionals, contractors, architects, design engineers, suppliers and sub contractors in order identify the most occurring causes of cost overruns in construction projects. In addition to this contemporary literature was studied and reviewed with a purpose to assess the current and ongoing issues in the construction industry. A questionnaire was distributed among respondents on cost performance of various completed and under construction projects, with a view to highlight the concrete reasons which push the projects out of approved budgets. The major conclusions from this research paper which have been drawn are; corruption and bribery, political interests, poor site management, delay in site mobilization, rigid attitude by consultants, extra work without approvals, frequent changes during execution, gold platting, safety and health and limited access to job sites. In order to avoid, eliminate or mitigate effects of these causes viable recommendations have been recommended. Keywords: Cost Performance, Construction Industry, Pakista

Impact of Human Resources Management Practices on Turnover, Productivity and Corporate Financial Performance

In developing countries, the human resource availability is quite easy but the most unfortunate part is its effective and efficient management. It is a well established fact that it is human beings behind the machines which can drive or drown the organizations. Human behavior and psychology is driven and motivated by varying degree of factors. The researchers across the globe have evolved and successfully practiced certain HRM techniques in order to achieve best performance and productivity from human capital. Unfortunately this area remained neglected and human resource could not be exploited to its full potential in Pakistan despite the fact that the country possesses  one of the best human capital in the world. This paper is an Endeavour to identify the best Human Resource Management practices applicable to Pakistani environments and analyze their positive effects on labor turnover, productivity and corporate financial performance. In order to achieve this objective, a survey questionnaire was designed and disseminated among respondents. A total of 200 questionnaires were distributed, out of which 145 completed questionnaires were received. The authors analyzed the data by using statpro software. the major conclusions and findings were; Need for articulation of vision, mission and values for organization, lack of performance management system, lack of benefit and compensation program, issue of corporate loyalty, poor workforce alignment, absence of HR development and training programs, lack of Human Resource Information System(HRIS),and non adoption of TQM. Keywords: HRM, Productivity, Pakistan, Turnover

Identification of GLI1 and KIAA0825 Variants in Two Families with Postaxial Polydactyly

Polydactyly is a rare autosomal dominant or recessive appendicular patterning defect of the hands and feet, phenotypically characterized by the duplication of digits. Postaxial polydactyly (PAP) is the most common form and includes two main types: PAP type A (PAPA) and PAP type B (PAPB). Type A involves a well-established extra digit articulated with the fifth or sixth metacarpal, while type B presents a rudimentary or poorly developed superfluous digit. Pathogenic variants in several genes have been identified in isolated and syndromic forms of polydactyly. The current study presents two Pakistani families with autosomal recessive PAPA with intra- and inter-familial phenotype variability. Whole-exome sequencing and Sanger analysis revealed a novel missense variant in KIAA0825 (c.3572C>T: p.Pro1191Leu) in family A and a known nonsense variant in GLI1 (c.337C>T: p.Arg113*) in family B. In silico studies of mutant KIAA0825 and GLI1 proteins revealed considerable structural and interactional modifications that suggest an abnormal function of the proteins leading to the disease phenotype. The present study broadens the mutational spectrum of KIAA0825 and demonstrates the second case of a previously identified GLI1 variant with variable phenotypes. These findings facilitate genetic counseling in Pakistani families with a polydactyly-related phenotype

Enhancement of solubility and dissolution rate of ebastine fast-disintegrating tablets by solid dispersion method

Purpose: To investigate the efficiency of different solubilizing agents in improving solubility as well as dissolution rate of ebastine (a BCS class II drug) by incorporating prepared solid dispersion into fast disintegrating tablets.Method: The solubility of ebastine was determined in distilled water, lipids and solubilizing agents. Subsequently, the binary solid dispersions were prepared by kneading method using varying weight ratios of ebastine and solubilizing agents. The solid dispersions were then incorporated into fast disintegrating tablets (SD-FDT). Central composite rotatable design (CCD) was used to determine the impact of super disintegrating agents on disintegration time and friability of tablets. The solubility and dissolution rate of developed SD-FDT were compared with a marketed brand. The solid dispersion particles were characterized by Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), powder x-ray diffraction (P-XRD) and scanning electron microscopy (SEM).Results: The saturated solubility of pure ebastine in water was 0.002 ± 0.041 mg/ml while the aqueous solubility of EBT/poloxamer solid dispersion SET3 (P) was 0.018 ± 2.510 mg/ml; on the other hand, EBT/soluplus solid dispersion SET1(S) has an aqueous solubility of 0.242 ± 1.390 mg/ml. Within 30 min, drug release was 14.00 ± 1.77, 78.00 ± 2.31 and 98.70 ± 2.54 % from pure EBT, SET3 (P) and SET1(S), respectively.Conclusion: The solubility and dissolution rate of ebastine has been successfully enhanced by incorporating its solid dispersion in fast-disintegrating tablets (SD-FDT). Keywords: Ebastine, Solid dispersion, Poloxamer 188, Soluplus, Solubility, Dissolutio

Neuroprotective Effect of Quercetin Against the Detrimental Effects of LPS in the Adult Mouse Brain

Chronic neuroinflammation is responsible for multiple neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. Lipopolysaccharide (LPS) is an essential component of the gram-negative bacterial cell wall and acts as a potent stimulator of neuroinflammation that mediates neurodegeneration. Quercetin is a natural flavonoid that is abundantly found in fruits and vegetables and has been shown to possess multiple forms of desirable biological activity including anti-inflammatory and antioxidant properties. This study aimed to evaluate the neuroprotective effect of quercetin against the detrimental effects of LPS, such as neuroinflammation-mediated neurodegeneration and synaptic/memory dysfunction, in adult mice. LPS [0.25 mg/kg/day, intraperitoneally (I.P.) injections for 1 week]-induced glial activation causes the secretion of cytokines/chemokines and other inflammatory mediators, which further activate the mitochondrial apoptotic pathway and neuronal degeneration. Compared to LPS alone, quercetin (30 mg/kg/day, I.P.) for 2 weeks (1 week prior to the LPS and 1 week cotreated with LPS) significantly reduced activated gliosis and various inflammatory markers and prevented neuroinflammation in the cortex and hippocampus of adult mice. Furthermore, quercetin rescued the mitochondrial apoptotic pathway and neuronal degeneration by regulating Bax/Bcl2, and decreasing activated cytochrome c, caspase-3 activity and cleaving PARP-1 in the cortical and hippocampal regions of the mouse brain. The quercetin treatment significantly reversed the LPS-induced synaptic loss in the cortex and hippocampus of the adult mouse brain and improved the memory performance of the LPS-treated mice. In summary, our results demonstrate that natural flavonoids such as quercetin can be beneficial against LPS-induced neurotoxicity in adult mice

A comparative absorption study of sucrosomial® orodispersible vitamin D3 supplementation vs. a reference chewable tablet and soft gel capsule vitamin D3 in improving circulatory 25(OH)D levels in healthy adults with vitamin D deficiency—Results from a prospective randomized clinical trial

BackgroundVitamin D (Vit D) deficiency (VDD), associated with diverse health conditions, is commonly treated with Vit D3 supplements. However, the gastrointestinal (GI) absorption of Vit D3 in different formulations has not been well studied.ObjectiveWe aimed to compare the absorption of an innovative phospholipids-sucrester matrix biodelivery vehicle-based (sucrosomial®) orodispersible Vit D3 preparation against a reference chewable tablet and soft gel capsule (SGC) Vit D3 formulations in Vit D-deficient healthy adults.MethodsIn study 1, 25 subjects were randomized to receive a weekly single dose of 200,000 IU of sucrosomial® Vit D3 (n = 12) or chewable tablet Vit D3 (n = 13) for 3 weeks. In study 2, 20 subjects were randomized to receive a single dose of 200,000 IU every other week of sucrosomial® Vit D3 (n = 10) or SGC Vit D3 (n = 10) for 6 weeks. Circulatory 25-hydroxyvitamin D3 [25(OH)D] levels were reassessed after 2, 3, and 6 weeks in study 1 and after 4 and 6 weeks in study 2.ResultsIn study 1, after 2 weeks, circulatory 25(OH)D levels increased significantly in both Vit D3 treatment groups (p < 0.0001) but improved markedly in the sucrosomial® Vit D3 group, with no further considerable change after 3 and 6 weeks in both groups. Overall, at all three follow-ups, sucrosomial® Vit D3 treatment achieved significantly higher and sustained 25(OH)D levels (p < 0.001). In study 2, after 4 weeks, both Vit D3 treatment groups showed significant improvement in circulatory 25(OH)D levels (p < 0.0001) but substantially higher in the sucrosomial® group with statistically significant differences between the two treatment groups (p = 0.02). At the 6-week follow-up, only subjects in the sucrosomial® Vit D3 group showed a further increase in circulatory 25(OH)D levels (p = 0.049), but no further significant changes in the levels of the SGC Vit D3 group (p = 0.062), showing a statistically significant difference between the two treatment groups (p = 0.002). The Vit D3 treatment was well tolerated by all participants, and no treatment-emergent effects or serious adverse events were reported.ConclusionOur results suggest that the sucrosomial® Vit D3 preparation absorbs efficiently in the GI system, achieving adequately higher and sustained circulatory Vit D levels in VDD, and thus can effectively contribute to the body protection against VDD-associated health conditions.Clinical trial registrationclinicaltrials.gov, identifier: NCT05706259

The possible 'calming effect' of subchronic supplementation of a standardised phospholipids carrier-based Melissa officinalis L. extract in healthy adults with emotional distress and poor sleep conditions: results from a prospective, randomized, double-blinded, and placebo-controlled clinical trial

Background: Emotional distress conditions such as depression, anxiety, stress, and poor sleep are widespread health problems that have a significant impact on people’s lives. Conventional drugs are commonly prescribed to treat emotional distress and poor sleep conditions; however, these medications have several limitations and have shown multiple side effects. Over recent years botanicals-based pharmacological agents have gained increasing research and clinical interest in the management of emotional distress and sleep disorder. Of note, Melissa officinalis L. (MO) leaf extract has demonstrated considerable neuropharmacological properties both in animal and human studies and has emerged as a promising natural “calming agent.” However, research in this area is limited, and more studies are needed to validate its efficacy in amelioration of emotional distress and poor sleep conditions. Objectives: We aimed to assess the pharmacological effects of subchronic supplementation of an innovative standardised phospholipid carrier-based MO aqueous extract on emotional distress and poor sleep conditions. Design: A 3-week prospective, randomised, placebo-controlled, parallel-group, double-blinded clinical trial was conducted in 100 healthy adults complaining of a moderate degree of depression, anxiety, or stress, with scores of ≥14, ≥10, and ≥19, respectively, in the self-report Depression, Anxiety, and Stress Scale (DASS-42) or poor sleep, as indicated by the score of >5 in the Pittsburgh Sleep Quality Index (PSQI) scale. In addition, the impact of emotional distress and/or poor sleep on participants’ mental wellbeing, emotional feelings, and quality of life was also assessed using the self-reported Warwick–Edinburgh Mental Wellbeing Scale (WEMWBS), Positive and Negative Affect Schedule (PANAS) scale, and quality of life (WHO-QoL-BREF) scale, respectively. Results: Oral supplementation of 200 mg of phospholipid-based MO aqueous extract (Relissa™) tablets twice a day (i.e., 400 mg/day) for 3 weeks led to significant improvements in the depressive mood, anxiety, stress, positive and negative affect (emotional feelings), overall mental wellbeing, and quality-of-life scores (all p values <0.001). Supplementation of MO extract was well tolerated, and no treatment-emergent effects or serious adverse events were reported. Conclusion: According to the results of this study, the phospholipid carrier-based MO aqueous extract possesses considerable neuropharmacological properties, and its supplementation may provide a promising therapeutic option for the management of moderate emotional distress and/or poor sleep conditions

Benefits and Impediments in Implementing Tqm in Pakistani Construction Sector

Construction Industry acquires a significant financial position and stature towards the development of physical infrastructure in Pakistan. It is regarded as, amongst the major contributors in the growth of Gross Domestic Product (GDP). Nexus to this, it has also rendered enormous contributions in offering job opportunities and eradication of poverty in the country. Despite all these meritorious contributions, the industry’s performance and potential is severely been affected by quality related issues like, wastage of construction material, re-works, scraps and customer dissatisfaction. The tools and techniques being used currently for measurement of quality are outlived and outdated. This paper is an endeavor to highlight the potential benefits of implementing Total Quality Management (TQM) philosophy. Also to seek out kinks and impediments which down play the adoption of TQM in the industry. For this purpose a survey questionnaire was designed for carrying out survey on this subject. The target respondents were architects, design professionals, engineers, contractors, sub contractors, suppliers, sponsors and the clients. The major findings were,  misconception about the implementation of TQM in construction and its benefits, lack of quality policy, lack of training, lack of resources, lack of management support, current bidding and tendering process and traditional project management concepts. To offset these problems, it has been suggested that adequate awareness and training must be imparted through effective quality policy and top management support. Keywords: Benefits, Construction sector, Impediments, Pakistan, TQM