Chemical Analysis and Biological Activities of Salvia lavandulifolia Vahl. Essential Oil

Genus Salvia is one of important genera belonging to family lamiaceae. Most of reported biological activities of Salvia usually attributed to its volatile oil. The chemical composition of essential oil from Salvia lavandulifolia was analyzed by GC/MS. A total of sixty seven components were identified in the oil of S. lavandulifolia representing 95.78% of the total oil. β-caryophyllene (11.87%), spathulenol (8.13%), neomenthol (7.75%), pulegone (6.97%), hexadecanoic acid (6.85%), germacrene-D (5.70%), bicyclogermacrene (4.53%), caryophyllene oxide (3.97%) and humulene (3.29%) were found to be the major constituents. The oil showed no antimicrobial and antileishmanial activities in a concentration up to 200 and20 µg/mL, respectively. It displayed a weak antimalarial activity (47 % inhibition) against P. flaciparium.The oil exhibited anti-inflammatory activity adopting iNOS inhibition assay with IC50of 30 µg/mL, but there is no cytotoxicity demonstrated by the oil at tested concentration of 100 µg/mL. Keywords: S. lavandulifolia, essential oil, antimalaria, antimicrobial, antiinflammtory, anticancer

Some Hermite-Hadamard and midpoint type inequalities in symmetric quantum calculus

The Hermite-Hadamard inequalities are common research topics explored in different dimensions. For any interval $[\mathrm{b_{0}}, \mathrm{b_{1}}]\subset\Re$, we construct the idea of the Hermite-Hadamard inequality, its different kinds, and its generalization in symmetric quantum calculus at $\mathrm{b_{0}}\in[\mathrm{b_{0}}, \mathrm{b_{1}}]\subset\Re$. We also construct parallel results for the Hermite-Hadamard inequality, its different types, and its generalization on other end point $\mathrm{b_{1}}$, and provide some examples as well. Some justification with graphical analysis is provided as well. Finally, with the assistance of these outcomes, we give a midpoint type inequality and some of its approximations for convex functions in symmetric quantum calculus

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Hermite–Hadamard Type Inequalities via Generalized Harmonic Exponential Convexity and Applications

In this work, we introduce the idea and concept of m–polynomial p–harmonic exponential type convex functions. In addition, we elaborate the newly introduced idea by examples and some interesting algebraic properties. As a result, several new integral inequalities are established. Finally, we investigate some applications for means. The amazing techniques and wonderful ideas of this work may excite and motivate for further activities and research in the different areas of science

High gain coupled inductor SEPIC based boost inverter using extended SPWM

This research work designs a high gain coupled inductor SEPIC (CI-SEPIC) based boost inverter. This topology presents low switching voltage stress, high output DC and AC voltage and highly efficient system, which makes it suitable for renewable energy applications. A seventh order system is obtained through dynamic modelling of the CI-SEPIC converter for which PID controller is designed to track the reference value. The extended sine-wave pulse width modulation (ESPWM) has maintained the high gain without compromising the efficiency and ensured low voltage stress on the switching devices. Simulation and experimental results validated that CI-SEPIC based boost inverter with ESPWM achieved high dc gain of 15.98, boost factor of 25, exceptional dc-ac coupling with minimum possible capacitance of 3.3uF, decreased device stress by 33% and smaller size of the complete system

Minimizing flow completion times in data centers

Abstract — For provisioning large-scale online applications such as web search, social networks and advertisement systems, data centers face extreme challenges in providing low latency for short flows (that result from end-user actions) and high throughput for background flows (that are needed to maintain data consistency and structure across massively distributed systems). We propose L2DCT, a practical data center transport protocol that targets a reduction in flow completion times for short flows by approx-imating the Least Attained Service (LAS) scheduling discipline, without requiring any changes in application software or router hardware, and without adversely affecting the long flows. L2DCT can co-exist with TCP and works by adapting flow rates to the extent of network congestion inferred via Explicit Congestion Notification (ECN) marking, a feature widely supported by the installed router base. Though L2DCT is deadline unaware, our results indicate that, for typical data center traffic patterns and deadlines and over a wide range of traffic load, its deadline miss rate is consistently smaller compared to existing deadline-driven data center transport protocols. L2DCT reduces the mean flow completion time by up to 50 % over DCTCP and by up to 95 % over TCP. In addition, it reduces the completion for 99th percentile flows by 37 % over DCTCP. We present the design and analysis of L2DCT, evaluate its performance, and discuss an implementation built upon standard Linux protocol stack. I