Synthesis and characterization of some potential biologically active niclosamide derivatives

Compounds with 2-hydroxy-benzanilide core are recognized for their biological effects. Niclosamide, in particular, is authorized for its anti-helmintic properties and, recently, demonstrated additional effects like antitumoral and antiviral ones. Thus, we considered worthwhile to synthesize some niclosamide derivatives, which could possess enhanced biological activity. Starting from 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide and methyl/ethyl α-halogenated acid esters were obtained methyl/ethyl esters. In order to prove the structural identity of the newly synthesized compounds, modern physico-chemical methods (FTIR, 1H-NMR, 13C-NMR) were used. The data obtained for the analyzed compounds proved their identity and confirm their structure