Effect of physical exercise cessation on strength, functional, metabolic and structural outcomes in older adults:a protocol for systematic review and meta-analysis

INTRODUCTION: There is not a doubt that tailored exercise is an effective non-pharmacological approach for preventing, mitigating and even reversing ageing-related alterations. However, older adults are likely to experience prolonged periods of inactivity and training cessation periods as a consequence of falls or hospitalisation. Although recent evidence supports that exercise could have a protective effect and help in recovering, there is to date a lack of consensus about what kind of physical exercise prescription and training duration would produce better outcomes after training cessation periods. The current study will determine the effects that available exercise prescriptions produced in older adults in preserving physical conditioning following inactivity periods. METHODS AND ANALYSIS: A systematic search of the literature will be conducted in three databases, namely PubMed, Scopus and Web of Science, from inception to 1 February 2021. Only randomised controlled trials written in English or Spanish will be eligible. No year of publication restriction will be applied. Eligible studies will contain information on population (older adults over 60 years old), intervention (inactivity period, exercise programme their duration), comparator (treatment as usual or waiting list) and outcomes (strength, functional capacity, metabolic health and skeletal muscle structure). Two independent reviewers will (1) search, screen and select studies, (2) extract data about their main characteristics and (3) evaluate their methodological and reporting quality. When disagreements emerge, the reviewers will discuss to reach a consensus. We plan to conduct meta-analysis to quantitatively synthesise the effects under study. ETHICS AND DISSEMINATION: As systematic reviews use publicly available data, no formal ethical review and approval are needed. Findings will be published in a peer-reviewed journal(s) and presented at conferences. PROSPERO REGISTRATION NUMBER: CRD42021235092

Agricultura, alimentación y uso del combustible: aplicación de modelos etnográficos en Arqueobotánica

We present ethnographical infomation particularly from the Jbala region in northern Marocco in order to offer archaeologists and archaeobotanists new data that may help in the questions and hypothesis we address to the archaeological record. We deal with these subjects: 1) the cultivation of einkorn (Triticum monococcum), agrarian practices and processing; 2) Conservation and storage of plant foods; 3) Use of cow dung as fuel, tempering of floors and walls and for recipient making; 4) Fuelwood: use, collection, leaf-foddering residues and woodland conservation.El trabajo etnoarqueológico en Marruecos se realiza en el marco del proyecto: Las primeras comunidades campesinas de la Región Cantábrica. El aporte de la etnoarqueología en Marruecos, financiado por la Fundación Marcelino Botín.Peer reviewe

Azolium-based systems: application of an anion exchange resin (A- form) method and 1H NMR analysis of the charged-assisted (C<br>H)+·anion hydrogen bonds

The counteranion exchange of quaternary 1,2,3-triazolium salts was examined using a simple method that permitted halide ions to be swap for a variety of anions using an anion exchange resin (A¯ form). The method was applied to 1,2,3-triazolium-based ionic liquids and the iodideto- anion exchange proceeded in excellent to quantitative yields, concomitantly removing halide impurities. Additionally, an anion exchange resin (N3¯ form) was used to obtain the benzyl azide from benzyl halide under mild reaction. Likewise, following a similar protocol, bis(azidomethyl)arenes were also synthesized in excellent yields. The results of a proton NMR spectroscopic study of simple azolium-based ion pairs are discussed, with attention focused on the significance of the charged-assisted (CH)+···anion hydrogen bonds of simple azolium systems such as 1-butyl-3-methylimidazolium and 1-benzyl-3-methyl-1,2,3-triazolium salts

What Can You Do with Educational Technology that is Getting More Human?

Proceeding of: Tenth IEEE Global Engineering Education Conference (EDUCON 2019), 9-11 April, 2019, Dubai, UAE.Technology is advancing at an ever-increasing speed. The backend capabilities and the frontend means of interaction are revolutionizing all kinds of applications. In this paper, we analyze how the technological breakthroughs seem to make educational interactions look smarter and more human. After defining Education 4.0 following the Industry 4.0 idea, we identify the key breakthroughs of the last decade in educational technology, basically revolving around the concept cloud computing, and imagine a new wave of educational technologies supported by machine learning that allows defining educational scenarios where computers interact and react more and more like humans.The authors would like to primarily acknowledge the support of the eMadrid Network, which is funded by the Madrid Regional Government (Comunidad de Madrid) with grant No. S2018/TCS-4307. This work has also received partial support from FEDER/Ministerio de Ciencia, Innovación y Universidades-Agencia Estatal de Investigación through Project RESET (TIN2014-53199-C3-1-R) and Project Smartlet (TIN2017-85179-C3-1-R). Partial support has also been received from the European Commission through Erasmus+ projects, in particular, projects COMPASS (Composing Lifelong Learning Oppor-tunity Pathways through Standards-based Services, 2015-1-EL01-KA203-014033), COMPETEN-SEA (Capacity to Organize Massive Public Educational Opportunities in Universities in Southeast Asia, 574212-EPP-1-2016-1-NL-EPPKA2-CBHE-JP), LALA (Building Capacity to use Learning Analytics to Improve Higher Education in Latin America, 586120-EPP-1-2017-1-ES-EPPKA2-CBHE-JP), and InnovaT (Innovative Teaching across Continents: Universities from Europe, Chile, and Peru on an Expedition, 598758-EPP-1-2018-1-AT-EPPKA2-CBHE-JP). UNESCO Chair "Scalable Digital Education for All" at Universidad Carlos III de Madrid is also gratefully acknowledged.Publicad

Boosting interaction with educational technology

Proceeding of: 2017 IEEE Global Engineering Education Conference (EDUCON), 25-28 April 2017, Athens, Greece.The MOOC movement has helped faculty in focusing on how to lecture. However, once this is done, it would not make sense not to use this content for on-campus classes. In this paper, we will explain how to harness top content created for MOOCs to improve on-campus classes, where the personal interaction is a key added feature. Interactive practices and on-site interaction, especially in-class interaction, are of particular relevance in the evolution of Higher Education towards a more effective learning.The eMadrid Excellence Network is being funded by the Madrid Regional Government (Comunidad de Madrid) with grant No. S2013/ICE-2715. This work also received partial support from the Spanish Ministry of Economy and Competitiveness, Project RESET (TIN2014-53199-C3-1-R) and fellowship FPDI-2013-17411, and from the European Commission through Erasmus+ projects MOOC-Maker (561533-EPP-1-2015-1-ES-EPPKA2-CBHE-JP) and SHEILA (562080-EPP-1-2015-1-BE-EPPKA3-PI-FORWARD).Publicad

Expression of DDX11 and DNM1L at the 12p11 Locus Modulates Systemic Lupus Erythematosus Susceptibility

This study employed genetic and functional analyses using OASIS meta-analysis of multiple existing GWAS and gene-expression datasets to identify novel SLE genes. Methods: Four hundred and ten genes were mapped using SNIPPER to 30 SLE GWAS loci and investigated for expression in three SLE GEO-datasets and the Cordoba GSE50395-dataset. Blood eQTL for significant SNPs in SLE loci and STRING for functional pathways of differentially expressed genes were used. Confirmatory qPCR on SLE monocytes was performed. The entire 12p11 locus was investigated for genetic association using two additional GWAS. Expression of 150 genes at this locus was assessed. Based on this significance, qPCRs for DNM1L and KRAS were performed. Results: Fifty genes were differentially expressed in at least two SLE GEO-datasets, with all probes directionally aligned. DDX11, an RNA helicase involved in genome stability, was downregulated in both GEO and Cordoba datasets. The most significant SNP, rs3741869 in OASIS locus 12p11.21, containing DDX11, was a cis-eQTL regulating DDX11 expression. DDX11 was found repressed. The entire 12p11 locus showed three association peaks. Gene expression in GEO datasets identified DNM1L and KRAS, besides DDX11. Confirmatory qPCR validated DNM1L as an SLE susceptibility gene. DDX11, DNM1L and KRAS interact with each other and multiple known SLE genes including STAT1/STAT4 and major components of IFN-dependent gene expression, and are responsible for signal transduction of cytokines, hormones, and growth-factors, deregulation of which is involved in SLE-development. Conclusion: A genomic convergence approach with OASIS analysis of multiple GWAS and expression datasets identified DDX11 and DNM1L as novel SLE-genes, the expression of which is altered in monocytes from SLE patients. This study lays the foundation for understanding the pathogenic involvement of DDX11 and DNM1L in SLE by identifying them using a systems-biology approach, while the 12p11 locus harboring these genes was previously missed by four independent GWAS

Flint ‘figurines’ from the Early Neolithic site of Kharaysin, Jordan

During the Early Neolithic in the Near East, particularly from the mid ninth millennium cal BC onwards, human iconography became more widespread. Explanations for this development, however, remain elusive. This article presents a unique assemblage of flint artefacts from the Middle Pre-Pottery Neolithic B (eighth millennium BC) site of Kharaysin in Jordan. Contextual, morphological, statistical and use-wear analyses of these artefacts suggest that they are not tools but rather human figurines. Their close association with burial contexts suggests that they were manufactured and discarded during mortuary rituals and remembrance ceremonies that included the extraction, manipulation and redeposition of human remains.This research is funded by the Ministerio de Ciencia, Innovación y Universidades, the Agencia Estatal de Investigación, the Fondo Europeo de Desarrollo Regional and Consejo Superior de Investigaciones Científicas. Project numbers: HAR2016-74999-P, PGC2018-096634-B-I00, RYC-2016-21108. The fieldwork is funded by the Palarq Foundation. J.S. was funded by a Marie Skłodowska-Curie Action (European Commission GA 750460; H2020-MSCA-IF-2016). We also acknowledge support of the publication fee by the CSIC Open Access Publication Support Initiative through its Unit of Information Resources for Research (URICI).Peer reviewe

Size effects on the tensile strength and fracture toughness of granitic rock in different tests

[Abstract:] This study investigates the tensile failure mechanisms in granitic rock samples at different scales by means of different types of tests. To do that, we have selected a granitic rock type and obtained samples of different sizes with the diameter ranging from 30 mm to 84 mm. The samples have been subjected to direct tensile strength (DTS) tests, indirect Brazilian tensile strength (BTS) tests and to two fracture toughness testing approaches. Whereas DTS and fracture toughness were found to consistently grow with sample size, this trend was not clearly identified for BTS, where after an initial grow, a plateau of results was observed. This is a rather complete database of tensile related properties of a single rock type. Even if similar databases are rare, the obtained trends are generally consistent with previous scatter and partial experimental programs. However, different observations apply to different types of rocks and experimental approaches. The differences in variability and mean values of the measured parameters at different scales are critically analysed based on the heterogeneity, granular structure and fracture mechanics approaches. Some potential relations between parameters are revised and an indication is given on potential sample sizes for obtaining reliable results. Extending this database with different types of rocks is thought to be convenient to advance towards a better understanding of the tensile strength of rock materials.The authors affiliated to the University of Vigo acknowledge the Spanish Ministry of Universities for partially funding this study as part of the project awarded under Contract Reference No. RTI2018-093563-B-I00, partially financed by means of ERDF funds from the EU

From software engineering to courseware engineering

Proceedings of: 2016 IEEE Global Engineering Education Conference (EDUCON), 10-13 April 2016, Abu Dhabi, United Arab EmiratesThe appearance of MOOCs has contributed to the use of educational technology in new contexts. As a consequence, many teachers face the challenge of creating educational content (courseware) to be offered in MOOCs. Although some best practices exist, it is true that most of the content is being developed without much thought about adequacy, reusability, maintainability, composability, etc. The main thesis at this paper is that we are facing a "courseware crisis" in the same way as there was a "software crisis" 50 years ago, and that the way out is to identify good engineering discipline to aid in the development of courseware. We need Courseware Engineering in the same way as at those times we needed Software Engineering. Therefore, the challenge is now to define and develop fundamentals, tools, and methods of Courseware Engineering, as an analogy to the fundamentals, tools, and methods that were developed in Software Engineering.The eMadrid Excellence Network is being funded by the Madrid Regional Government (Comunidad de Madrid) with grant No. S2013/ICE-2715. This work also received partial support from the Spanish Ministry of Economy and Competitiveness Project RESET (TIN2014-53199-C3-1-R) and from the European Erasmus+ projects MOOC-Maker (561533-EPP-1-2015-1-ES-EPPKA2-CBHE-JP) and SHEILA (562080-EPP-1-2015-BE-EPPKA3-PI-FORWARD). The first author would like to acknowledge fruitful discussions with Martin Wirsing and his group from LMU München during his research stay at this university with a scholarship from the Spanish Ministry of Education, Culture, and Sport