The clinical evidence and the role of imiquimod in the extramammary Paget disease

Extramammary Paget disease is a rare disease. Different treatment options are used for its management, among them treatment with imiquimod. Our aim is to clarify the efficacy and safety of the use of topical imiquimod cream in the treatment of extramammary Paget disease.In this article the current literature in Pubmed and Scopus on this topic is reviewed.According to the literature the topical use of imiquimod can be used as first-line treatment in different dosages and durations with excellent results, reaching a 87.5% cure rate with rare complications. The available evidence is currently limited to case reports and a single case series, but is definitely in favor of imiquimod use as an alternative treatment for extramammary Paget disease.</p

GRIGORIS LAMBRAKIS (1912-1963) – A GREEK OBSTETRICIAN AND WORLD RENOWNED ACTIVIST

Grigoris Lambrakis was a Greek politician, doctor, athlete, and faculty member of the Medical School of Athens University. As an athlete, Lambrakis held the Greek record for long jump for twenty-three years and he also won several gold medals in the Balkan Athletic Games. Lambrakis received an excellent medical education. As lecturer at the University of Athens, Lambrakis became a pioneer of Gynecological Endocrinology. His philanthropy was always evident during his medical career, but he also consistently attended international pacifist meetings and demonstrations. His medical work, and his performance as lecturer of Obstetrics and Gynaecology, have been neglected, if not overshadowed, by his political career. Lambrakis is recognized worldwide as a martyr for peace. The aim in this essay is to present his life, and especially to elucidate his medical achievements.Grigoris Lambrakis bio je grčki političar, liječnik, sportaš i član Medicinskog fakulteta Sveučilišta u Ateni. Kao sportaš, Lambrakis je držao grčki rekord u skoku u dalj tijekom dvadeset i tri godine, a osvojio je i nekoliko zlatnih medalja na Balkanskim atletskim igrama. Imao je izvrsno medicinsko obrazovanje. Kao predavač na Atenskom sveučilištu, Lambrakis je postao pionirom ginekološke endokrinologije. U njegovoj se liječničkoj karijeri očitovala njegova dobrohotnost. Također, neprestano je prisustvovao međunarodnim pacifističkim susretima i prosvjedima. Njegova je politička karijera zasjenila njegov medicinski rad i sveučilišni rad predavača opstetricije i ginekologije. Lambrakis je svjetski poznat kao mučenik za mir. Cilj je ovog izlaganja predstaviti njegov život, a posebice pojasniti njegova medicinska postignuća

The Role of 3-Dimensional Power Doppler Imaging in the Assessment of Ovarian Teratoma in Pregnancy: A Case Report

Background. Conventional sonography is the primary imaging tool for these pregnant women who present with an ovarian teratoma. In some cases, however, sonography diagnosis is difficult. We report a case of ovarian teratoma during pregnancy diagnosed by three-dimensional Power Doppler. The cyst was removed via laparotomy without fetal or maternal complications. Three-dimensional ultrasound with multiplanar view can better discriminate a benign ovarian teratoma from complex ovarian lesions or malignant tumors. Its role is significant especially during pregnancy as it may assist in determining which patients are requiring surgery and which are not. The results of three-dimensional sonography and magnetic resonance (MR) were equal but the role of MR imaging is limited in early pregnancy. Conclusions. Three-dimensional technique is a reliable diagnostic modality for preoperative assessment of an ovarian teratoma as it can be performed during the first trimester of pregnancy

RAZVOJ ROBOTA KROZ POVIJEST DO „DA VINCIJEVOG ROBOTA“

Da Vinci robot is increasingly used for operations adding the advantages of robots to the favor of medicine. This is a historical article with the aim to present the evolution of robots in the medical area from the time of ancient myths to Renaissance and finally to the current revolutionary applications. We endeavored to collect several elegant narratives on the topic. The use of imagination could help the reader to find similarities. A trip from the Greek myths of Hephaestus through Aristotle and Leonardo Da Vinci to the robots of Karel Capek and Isaac Asimov and finally the invention of the medical robots is presented.Da Vincijev robot se sve više koristi za operacije iskorištavajući prednosti robota u korist medicine. Ovo je povijesni članak u kojemu je cilj predstaviti evoluciju robota u medicini od vremena drevnih mitova do renesanse i konačno do sadašnjih revolucionarnih aplikacija. Nastojali smo prikupiti nekoliko elegantnih priča na tu temu. Korištenje imaginacije može pomoći čitatelju pronaći sličnosti. Predstavljeno je putovanje od grčkih mitova o Hefestu preko Aristotela i Leonarda da Vincija do robota Karela Čapeka i Isaaca Asimova te konačno izuma medicinskih robota

World Wide Web Resources on Obstetrical and Gynecological Infections

Modern information and communications technology has provided medical students and practitioners around the world with a new, valuable, and easy-to-use way to retrieve potentially useful information. Using previously described by our research group methodology, we generated a list of 50 Internet resources in the field of obstetrical and gynecological infections. We believe that the availability of such a list will help in the education of students and clinicians interested in obstetrical and gynecological infections

Tranexamic Acid (TXA) for the Hemostatic Treatment of Post-Partum Hemorrhage (PPH): What Key Points Have We Learnt After All These Years?

Post-partum bleeding or post-partum hemorrhage (PPH) is often defined as the loss of more than 500 mL of blood after vaginal delivery or 1000 mL of blood after cesarean section following the delivery of a child [...]

Paraovarian tumor of borderline malignancy: A case report

Paraovarian tumors of borderline malignancy (PTBM) are exceedingly rare, with only slightly over 60 cases reported worldwide. This report presents the case of a 22-year-old nulliparous patient who incidentally discovered a left paraovarian mass during a routine abdominal ultrasound. Subsequent MRI revealed a 2.5×2.1 cm cystic lesion located in close proximity to, but outside of, the left ovary, with no other pathological findings. A laparoscopic cystectomy was performed with meticulous care to prevent tumor spillage, and the patient experienced an uneventful recovery. Histopathological examination unveiled irregularly shaped tissue measuring 2.2×1.2×1 cm, characterized by fibrous tissue/wall with spindle cell stroma and an epithelium displaying features consistent with a serous borderline tumor. Our multidisciplinary team recommended diligent follow-up. This case contributes to the existing literature on PTBM and highlights the imperative for additional cases to enhance our comprehension of the optimal management of these exceedingly rare tumors

PRIMJENA MRAVLJIH ČELJUSTI KAO KIRURŠKIH KOPČI U DOBA GRČKOG DOMOLJUBA YANNISA MAKRIYANNISA (1797.–1864.)

The use of ant mandibles as surgical clips was documented by the ancient Indian physicians Susruta and Charaka as early as 1000 BC and continued in some world areas into the early 1900s. According to the memoirs of the Greek revolutionary general Ioannis Makriyannis, this technique was also applied in the battlefields of the Greek Revolution for Independence between 1821 and 1832.Još 1000 g. pr. n. e. indijski liječnici Sušruta i Čaraka spominju primjenu mravljih čeljusti kao kirurških kopči, koja se nastavila u nekim dijelovima svijeta sve do prve polovice XIX. stoljeća. Prema zapisima iz sjećanja grčkog revolucionara, generala Yannisa Makriyannisa, ova se tehnika primjenjivala i na bojištima u Grčkoj tijekom Revolucije za neovisnost od 1821. do 1832