6 research outputs found
Breast cancer or metastasis? An unusual case of metastatic malignant pleural mesothelioma to the breast
Background: Metastases to the breast from extramammary malignancies are very rare, and ruling out the
diagnosis of primary breast tumor is important in order to decide on clinical management and predict prognosis.
Case presentation: Clinical examination revealed in a 49-year-old hairdresser a 3-cm hard lump adherent to
the underlying layers in the right breast. Trucut biopsy was performed. Histology showed a solid proliferation of
medium-sized neoplastic polygonal cells. Immunohistochemical analysis showed tumor cells diffusely positive for
cytokeratin 8/18 and calretinin and focally positive for cytokeratin 5/6 and Wilms’ tumor 1, e-cadherin, and human
bone marrow endothelial-1. Estrogen receptors and progesterone receptors were negative. The final diagnosis was
metastatic epithelioid malignant pleural mesothelioma.
Conclusions: Immunohistochemistry is an important tool for a conclusive diagnosis of malignant pleural
mesothelioma. Owing to the degree of histological and immunohistochemical overlap, a high level of clinical
suspicion is essential in order to avoid unnecessary mutilating surgery
Epirubicin. A new entry in the list of fetal cardiotoxic drugs? Intrauterine death of one fetus in a twin pregnancy. Case report and review of literature
BACKGROUND: Current knowledge indicate that epirubicin administration in late
pregnancy is almost devoid of any fetal cardiotoxicity. We report a twin
pregnancy complicated by breast cancer in which epirubicin administration was
causatively linked to the death of one twin who was small for gestational age
(SGA) and in a condition of oligohydramnios and determined the onset of a
transient cardiotoxicity of the surviving fetus/newborn.
CASE PRESENTATION: A 38-year-old caucasic woman with a dichorionic twin pregnancy
was referred to our center at 20 and 1/7Â weeks for a suspected breast cancer,
later confirmed by the histopathology report. At 31 and 3/7Â weeks, after the
second chemotherapy cycle, ultrasound examination evidenced the demise of one
twin while cardiac examination revealed a monophasic diastolic ventricular
filling, i.e. a diastolic dysfunction of the surviving fetus who was delivered
the following day due to the occurrence of grade II placental abruption. The role
of epirubicin cardiotoxicity in the death of the first twin was supported by
post-mortem cardiac and placental examination and by the absence of structural or
genomic abnormalities that may indicate an alternative etiology of fetal demise.
The occurrence of epirubicin cardiotoxicity in the surviving newborn was
confirmed by the report of high levels of troponin and transient left ventricular
septal hypokinesia.
CONCLUSION: Based on our findings we suggest that epirubicin administration in
pregnancy should be preceded by the screening of some fetal conditions like SGA
and oligohydramnios that may increase its cardiotoxicity and that, during
treatment, the diastolic function of the fetal right ventricle should be
specifically monitored by a pediatric cardiologist; also, epirubicin and
desamethasone for lung maturation should not be closely administered since
placental effects of glucocorticoids may increase epirubicin toxicity
Stem cell factor activates telomerase in mouse mitotic spermatogonia and in primordial germ cells
The discovery of sterility in the descendants of telomerasenull mutant mice, owing to the lack of spermatogonia proliferation, has drawn attention to the role of telomerase activity in mouse spermatogenesis. Since spermatogonia proliferation is under Kitl control, we explored its possible role in the regulation of telomerase activity. We show that Kitl induces telomerase activity in mitotic spermatogonia and increases the mRNA levels of both the catalytic subunit form and the telomerase RNA template. The increase of telomerase activity by Kitl is blocked by the presence of the PI3K inhibitor LY294002. Kit-positive proliferating male primordial germ cells (PGCs) show low levels of telomerase activity, but they increase telomerase activity upon Kitl stimulation. Diplotene-arrested growing oocytes that reexpress Kit do not increase telomerase activity upon Kitl stimulation. Our data suggest that the induction of telomerase by Kitl may contribute to the self-renewing potential of male germ cells and of PGCs
Breast cancer during pregnancy: a retrospective study on obstetrical problems and survival
Breast cancer is one of the most common cancers occurring in pregnancy. Data on survival of these patients and their obstetrical complications are still limited. We conducted a case-control, retrospective study to evaluate the overall survival (OS) of 22 patients with breast cancer in pregnancy (BCP) and 45 non-pregnant women with breast cancer (BC) matched for age, stage and hormonal status. Survival of BCP and BC patients using Kaplan-Meier analysis was similar (86.4% in cases and 80% in controls p=0.392) and BCP patients had survival consistent with the stage of the disease, providing that the treatment had been in agreement with the recommended protocols. The overall incidence of premature delivery was 54.6% and complications were observed in three newborns out of 23 (13%). Preterm labor induction without any obstetrical indication following woman's request to continue chemotherapy outside pregnancy can be reduced by explaining the risks of early delivery and the lack of effects of many chemotherapeutic regimens on the fetus. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved
Serum antiphospholipid antibodies in transplanted patients: potential follow-up markers to assess pregnancy risk?
Organ transplantations induce Antiphospholipid antibodies formation, but these autoantibodies seem to not play a pathogenic prothrombotic role in pregnancy because they significantly decrease during pregnanc