10 research outputs found
An integrative computational approach to effectively guide experimental identification of regulatory elements in promoters
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An integrative computational approach to effectively guide experimental identification of regulatory elements in promoters.
Get PDFTranscriptional activity of genes depends on many factors like DNA motifs, conformational characteristics of DNA, melting etc. and there are computational approaches for their identification. However, in real applications, the number of predicted, for example, DNA motifs may be considerably large. In cases when various computational programs are applied, systematic experimental knock out of each of the potential elements obviously becomes nonproductive. Hence, one needs an approach that is able to integrate many heterogeneous computational methods and upon that suggest selected regulatory elements for experimental verification
CisMiner: Genome-Wide In-Silico Cis-Regulatory Module Prediction by Fuzzy Itemset Mining
No full textCandidate SNP markers of aggressiveness-related complications and comorbidities of genetic diseases are predicted by a significant change in the affinity of TATA-binding protein for human gene promoters
No full textExploring features and function of Ss-riok-3, an enigmatic kinase gene from Strongyloides stercoralis
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