Reconsideration of Laparoscopic Cholecystectomy

We describe the surgical method of cases showing a distended gallbladder. Because the most important thing does not cause biliary tract injury, it is to find orientation carefully. The frequency of incidental gallbladder cancer was in 7 (0.7%) of the 983. Only cholecystectomy is necessary to be performed for Tis or T1 cancer, and surgery has to be changed to radical surgery for T2 cancer or deeper invasion. Laparoscopic cholecystectomy is already an established standard operation. In the presence of acute or severe chronic inflammation, special attention should be paid to these points

Variation of pro‐vasopressin processing in parvocellular and magnocellular neurons in the paraventricular nucleus of the hypothalamus: Evidence from the vasopressin‐related glycopeptide copeptin

Arginine vasopressin (AVP) is synthesized in parvocellular‐ and magnocellular neuroendocrine neurons in the paraventricular nucleus (PVN) of the hypothalamus. Whereas magnocellular AVP neurons project primarily to the posterior pituitary, parvocellular AVP neurons project to the median eminence (ME) and to extrahypothalamic areas. The AVP gene encodes pre‐pro‐AVP that comprises the signal peptide, AVP, neurophysin (NPII), and a copeptin glycopeptide. In the present study, we used an N‐terminal copeptin antiserum to examine copeptin expression in magnocellular and parvocellular neurons in the hypothalamus in the mouse, rat, and macaque monkey. Although magnocellular NPII‐expressing neurons exhibited strong N‐terminal copeptin immunoreactivity in all three species, a great majority (~90%) of parvocellular neurons that expressed NPII was devoid of copeptin immunoreactivity in the mouse, and in approximately half (~53%) of them in the rat, whereas in monkey hypothalamus, virtually all NPII‐immunoreactive parvocellular neurons contained strong copeptin immunoreactivity. Immunoelectron microscopy in the mouse clearly showed copeptin‐immunoreactivity co‐localized with NPII‐immunoreactivity in neurosecretory vesicles in the internal layer of the ME and posterior pituitary, but not in the external layer of the ME. Intracerebroventricular administration of a prohormone convertase inhibitor, hexa‐d‐arginine amide resulted in a marked reduction of copeptin‐immunoreactivity in the NPII‐immunoreactive magnocellular PVN neurons in the mouse, suggesting that low protease activity and incomplete processing of pro‐AVP could explain the disproportionally low levels of N‐terminal copeptin expression in rodent AVP (NPII)‐expressing parvocellular neurons. Physiologic and phylogenetic aspects of copeptin expression among neuroendocrine neurons require further exploration

Stochastic gound motion simulation for crustal earthquakes in Japan

In this study, an empirical simulation model of stochastic ground motion for crustal earthquakes in Japan is proposed based on the ground motion records observed by K-NET in Japan from 1997 to 2011. The proposed model is developed based on that by Rezaeian & Der Kiureghian (2010). The characteristics of ground motion depends on various parameters such as magnitude, distance from source to site and local site conditions (shallow soil as well as deep subsurface structure), which is included in the parameters in the proposed model. The proposed model is considered useful when conducting probabilistic risk analysis of structures such as base-isolated or vibration-controlled buildings.Non UBCUnreviewedThis collection contains the proceedings of ICASP12, the 12th International Conference on Applications of Statistics and Probability in Civil Engineering held in Vancouver, Canada on July 12-15, 2015. Abstracts were peer-reviewed and authors of accepted abstracts were invited to submit full papers. Also full papers were peer reviewed. The editor for this collection is Professor Terje Haukaas, Department of Civil Engineering, UBC Vancouver.Facult

A Framework for Seismic Design of Items in Safety-Critical Facilities for Implementing a Risk-Informed Defense-in-Depth-Based Concept

Recently, especially after the 2011 off the Pacific coast of Tohoku earthquake and the Fukushima Daiichi nuclear power plant accident, the need for treating residual risks and cliff-edge effects in safety-critical facilities has been widely recognized as an extremely important issue. In this article, the sophistication of seismic designs in safety-critical facilities is discussed from the viewpoint of mitigating the consequences of accidents, such as the avoidance of cliff-edge effects. For this purpose, the implementation of a risk-informed defense-in-depth-based framework is proposed in this study. A basic framework that utilizes diversity in the dynamic characteristics of items and also provides additional seismic margin to items important for safety when needed is proposed to prevent common cause failure and to avoid cliff-edge effects as far as practicable. The proposed method is demonstrated to be effective using an example calculation

Development of stochastic heterogeneous slip distribution model for simulation of earthquake ground motion

Ground motion simulation is an important tool for analyzing seismic risk in engineering systems. Recently, ground motion simulations using fault model are being widely applied. Characterized fault models are conveniently used to model the heterogeneous slip distribution on fault plane, which divides the fault into two areas, i.e., asperity area and background area. The model, however, is too simplified to model the complex characteristics of actual slip. In this paper, a model to simulate the slip distribution of the fault plane is proposed.Non UBCUnreviewedThis collection contains the proceedings of ICASP12, the 12th International Conference on Applications of Statistics and Probability in Civil Engineering held in Vancouver, Canada on July 12-15, 2015. Abstracts were peer-reviewed and authors of accepted abstracts were invited to submit full papers. Also full papers were peer reviewed. The editor for this collection is Professor Terje Haukaas, Department of Civil Engineering, UBC Vancouver.FacultyGraduat

Engineering Applications Using Probabilistic Aftershock Hazard Analyses: Aftershock Hazard Map and Load Combination of Aftershocks and Tsunamis

After the Tohoku earthquake in 2011, we observed that aftershocks tended to occur in a wide region after such a large earthquake. These aftershocks resulted in secondary damage or delayed rescue and recovery activities. In addition, it has been reported that there are regions where the intensity of the vibrations owing to the aftershocks was much stronger than those associated with the main shock. Therefore, it is necessary to consider the seismic risk associated with aftershocks. We used the data regarding aftershocks that was obtained from the Tohoku earthquake and various other historically large earthquakes. We investigated the spatial and temporal distribution of the aftershocks using the Gutenberg–Richter law and the modified Omori law. Subsequently, we previously proposed a probabilistic aftershock occurrence model that is expected to be useful to develop plans for recovery activities after future large earthquakes. In this study, the probabilistic aftershock hazard analysis is used to create aftershock hazard maps. We propose a hazard map focusing on the probability of aftershocks on the scale of the main shock for use with a recovery activity plan. Following the lessons learned from the 2011 Tohoku earthquake, we focus on the simultaneous occurrence of tsunamis and aftershocks just after a great subduction earthquake. The probabilistic aftershock hazard analysis is used to derive load combination equations of the load and resistance factor design. This design is intended to simultaneously consider tsunamis and aftershocks for tsunami-resistant designs of tsunami evacuation buildings

Load combination of aftershocks and tsunami for tsunami-resistant design

Occurrence of huge tsunami and numerous aftershocks are expected after a gigantic subduction earthquake occurs. Therefore, the important coastal structures (tsunami refuge buildings, seawalls and nuclear power plants etc.) must be designed against tsunami as well as ground shaking. In tsunami-resistant design, it is needed to consider that tsunami may arrive at the structure in a short time after the mainshock from the experience of 2011 Tohoku earthquake. When the action effects both from aftershocks and tsunami to the structure occur simultaneously, practically reasonable assessment of load combination from aftershocks and tsunami is needed. In order to treat the load combination problem reasonably, stochastic load combination technique can be used, which requires stochastic modeling of action effects from aftershocks and tsunami. Once the combined action effect is estimated reasonably, the reliability analysis follows, where load and resistance factors can be obtained under the condition that the conditional target reliability for a limit state function is given. Load combination method of aftershocks and tsunami on the tsunami-resistant design is demonstrated at some sites in Japan. Finally, load and resistance factor design format for the tsunami-resistant design is proposed.Non UBCUnreviewedThis collection contains the proceedings of ICASP12, the 12th International Conference on Applications of Statistics and Probability in Civil Engineering held in Vancouver, Canada on July 12-15, 2015. Abstracts were peer-reviewed and authors of accepted abstracts were invited to submit full papers. Also full papers were peer reviewed. The editor for this collection is Professor Terje Haukaas, Department of Civil Engineering, UBC Vancouver.Facult