SKRINING KADAR GLUKOSA DARAH, ASAM URAT DAN KOLESTEROL DI NEGERI SEITH KECAMATAN LEIHITU KABUPATEN MALUKU TENGAH

Non-communicable diseases (NCDs) is a local and global health problem. The metabolic keys to control NCDs are blood pressure, blood sugar level, and cholesterol level control. The three keys, including uric acid level, play a role in cerebrovascular disease such as coronary heart disease and ischemic stroke, which leads to death. Screening for those factors is one step to avoid increasing cardiovascular disease, leading to decreasing in NCDs. This is a health service activity to provide blood glucose, uric acid, and cholesterol data to support health workers in Negeri Seith. The respondent's blood, whose age was more than 35, was drawn after signing the informed consent. It was using the easy-touch device meter to collect the respondent's blood. The result showed that largely Seith community has a normal blood sugar level (78%), normal uric acid level in males and females (95.5% versus 96.8%), but a high level of cholesterol (40.6%). This activity is carried out according to giving appropriate data to the community and health workers to prevent the NCDs

GAMBARAN KADAR HEMOGLOBIN TERGLIKASI (HBA1C) PADA PASIEN DM TIPE 2 DENGAN KOMPLIKASI PJK DAN DM TIPE 2 NON-PJK DI RUMAH SAKIT BHAYANGKARA TK III DAN RUMAH SAKIT TNI AD TINGKAT II PROF. DR. J. A. LATUMETEN TAHUN 2022

Diabetes melitus (DM) adalah penyakit kronis yang sampai saat ini masih menjadi masalah utama dalam kesehatan masyarakat di Indonesia. DM terjadi karena adanya gangguan metabolisme pada tubuh yang ditandai dengan hiperglikemia yang disebabkan oleh kelainan sekresi insulin, kerja insulin, atau keduanya. Penyebab kematian terbesar di dunia adalah penyakit kardiovaskular, dimana lebih dari 50% berhubungan langsung dengan DM. Angka kematian pasien PJK dengan DM tipe 2 meningkat 2-4 kali dibandingkan dengan non-DM. Salah satu pemeriksaan yang digunakan untuk melihat keberhasilan pengobatan dan pengendalian gula darah  adalah pemeriksaan HbA1c. HbA1c digambarkan sebagai kadar glukosa darah dalam 1-3 bulan, karena 120 hari merupakan umur sel darah merah, sehingga HbA1c digunakan sebagai parameter utama dalam pengobatan penyakit DM. Penelitian ini dilakukan untuk melihat gambaran kadar hemoglobin (HbA1c) pada pasien DM tipe 2 yang disertai komplikasi PJK dan DM tipe 2 Non-PJK. Penelitian dilakukan di kota Ambon khususnya di Rumah Sakit Bhayangkara TK III dan Rumah Sakit TNI AD Tingkat II Prof. Dr. JA Latumeten dengan menggunakan teknik total sampling didapatkan 93 responden. Hasil penelitian ini yaitu pasien DM tipe 2 dengan komplikasi PJK kadar HbA1c 6.5% sebanyak 4 orang (12.1%), 6.6 – 8.5% sebanyak 5 orang (15.2%), 8.5% sebanyak 24 orang (72.7%), pada pasien DM tipe 2 Non-PJK kadar HbA1c 6.5% sebanyak 12 orang (20.0%), 6.6 – 8.5% sebanyak 14 orang (23.2%), 8.5% sebanyak 34 orang (56.7%). DM tipe 2 lebih  banyak terjadi pada usia ≥45 tahun baik dengan komplikasi PJK sebanyak 28 orang dengan rata-rata nilai HbA1c 10.25%, dan Non-PJK 52 orang dengan rata-rata nilai HbA1c 8.40%. DM tipe 2 lebih banyak terjadi pada jenis kelamin perempuan baik dengan komplikasi PJK sebanyak 21 orang dengan rata-rata nilai HbA1c 10.33% dan Non-PJK 35 orang dengan rata-rata nilai HbA1c 8.83%

Does caffeine ingestion before a short-term sprint interval training promote body fat loss?

We investigated the effect of caffeine ingestion combined with a 2-wk sprint interval training (SIT) on training-induced reductions in body adiposity. Twenty physically-active men ingested either 5 mg/kg of cellulose as a placebo (PLA, n=10) or 5 mg/kg of caffeine (CAF, n=10) 60 min before each SIT session (13×30 s sprint/15 s of rest). Body mass and skinfold thickness were measured pre- and post-training. Energy expenditure was measured at rest, during exercise, and 45 min after exercise in the first SIT session. Body fat was similar between PLA and CAF groups at pre-training (P\u3e0.05). However, there was a significant decrease in body fat after training in the CAF group (−5.9±4.2%, P\u3c0.05) but not in PLA (1.5±8.0%, P\u3e0.05). There was no difference in energy expenditure at rest and during exercise between PLA and CAF groups (P\u3e0.05), but the post-exercise energy expenditure was 18.3±21.4% greater in the CAF than in the PLA group (P\u3c0.05). In conclusion, caffeine ingestion before SIT sessions induced a body fat loss that may be associated with higher post-exercise energy expenditure

Breastfeeding moderates FTO related adiposity: a birth cohort study with 30 years of follow-up.

This study assessed the association of breastfeeding with body composition at 30 years, among subjects who have been prospectively followed since birth in a southern Brazilian city. We also evaluated whether breastfeeding moderated the association between the rs9939609 variant in the FTO gene and adiposity. At 30 years, total and predominant breastfeeding were positively associated with lean mass index and inversely with visceral fat thickness. Among subjects breastfed for <1 month, all outcomes showed monotonically increasing values with additional copies of the A allele in the FTO genotype (rs9939609). Associations among subjects breastfed for one month or longer tended to be in the same direction but showed lower magnitude and were less consistent; for all outcomes. Interactions had p values ≤ 0.05 for body mass index, fat mass index and waist circumference. Even among young adults, breastfeeding moderates the association between the FTO variant rs9939609 and body composition

Influence of HLA-DRB1 and HLA-DQB1 Alleles on IgG Antibody Response to the P. vivax MSP-1, MSP-3α and MSP-9 in Individuals from Brazilian Endemic Area

Background: the antibody response generated during malaria infections is of particular interest, since the production of specific IgG antibodies is required for acquisition of clinical immunity. However, variations in antibody responses could result from genetic polymorphism of the HLA class II genes. Given the increasing focus on the development of subunit vaccines, studies of the influence of class II alleles on the immune response in ethnically diverse populations is important, prior to the implementation of vaccine trials.Methods and Findings: in this study, we evaluated the influence of HLA-DRB1* and -DQB1* allelic groups on the naturally acquired humoral response from Brazilian Amazon individuals (n = 276) against P. vivax Merozoite Surface Protein-1 (MSP-1), MSP-3 alpha and MSP-9 recombinant proteins. Our results provide information concerning these three P. vivax antigens, relevant for their role as immunogenic surface proteins and vaccine candidates. Firstly, the studied population was heterogeneous presenting 13 HLA-DRB1* and 5 DQB1* allelic groups with a higher frequency of HLA-DRB1*04 and HLA-DQB1*03. the proteins studied were broadly immunogenic in a naturally exposed population with high frequency of IgG antibodies against PvMSP1-19 (86.7%), PvMSP-3 (77%) and PvMSP-9 (76%). Moreover, HLA-DRB1*04 and HLA-DQB1*03 alleles were associated with a higher frequency of IgG immune responses against five out of nine antigens tested, while HLA-DRB1* 01 was associated with a high frequency of non-responders to repetitive regions of PvMSP-9, and the DRB1*16 allelic group with the low frequency of responders to PvMSP3 full length recombinant protein.Conclusions: HLA-DRB1*04 alleles were associated with high frequency of antibody responses to five out of nine recombinant proteins tested in Rondonia State, Brazil. These features could increase the success rate of future clinical trials based on these vaccine candidates.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Yerkes National Primate Research Center BaseNational Center for Research Resources of the National Institutes of HealthNIHCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Inst Oswaldo Cruz, Lab Immunoparasitol, BR-20001 Rio de Janeiro, BrazilOswaldo Cruz Fdn Fiocruz, Ctr Technol Dev Hlth CDTS, Rio de Janeiro, BrazilInst Oswaldo Cruz, Lab Simulideos & Oncocercose, BR-20001 Rio de Janeiro, BrazilEmory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USAUniv Estado Rio de Janeiro, Histocompatibil & Cryopreservat Lab, Rio de Janeiro, BrazilUniversidade Federal de São Paulo, Ctr Terapia Celular & Mol CTCMol, Escola Paulista Med, São Paulo, BrazilEmory Univ, Sch Med, Div Infect Dis, Atlanta, GA USACDC Natl Ctr Infect Dis, Div Parasit Dis, Atlanta, GA USAUniversidade Federal de São Paulo, Ctr Terapia Celular & Mol CTCMol, Escola Paulista Med, São Paulo, BrazilFAPESP: 2009/15132-4Yerkes National Primate Research Center Base: RR00165NIH: RO1 AI0555994Web of Scienc

Search for R-parity-violating supersymmetry in events with four or more leptons in sqrt(s) =7 TeV pp collisions with the ATLAS detector

A search for new phenomena in final states with four or more leptons (electrons or muons) is presented. The analysis is based on 4.7 fb−1 of $\sqrt{s}=7\;\mathrm{TeV}$ proton-proton collisions delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in two signal regions: one that requires moderate values of missing transverse momentum and another that requires large effective mass. The results are interpreted in a simplified model of R-parity-violating supersymmetry in which a 95% CL exclusion region is set for charged wino masses up to 540 GeV. In an R-parity-violating MSUGRA/CMSSM model, values of m 1/2 up to 820 GeV are excluded for 10 < tan β < 40

Search for high-mass resonances decaying to dilepton final states in pp collisions at s√=7 TeV with the ATLAS detector

The ATLAS detector at the Large Hadron Collider is used to search for high-mass resonances decaying to an electron-positron pair or a muon-antimuon pair. The search is sensitive to heavy neutral Z′ gauge bosons, Randall-Sundrum gravitons, Z * bosons, techni-mesons, Kaluza-Klein Z/γ bosons, and bosons predicted by Torsion models. Results are presented based on an analysis of pp collisions at a center-of-mass energy of 7 TeV corresponding to an integrated luminosity of 4.9 fb−1 in the e + e − channel and 5.0 fb−1 in the μ + μ −channel. A Z ′ boson with Standard Model-like couplings is excluded at 95 % confidence level for masses below 2.22 TeV. A Randall-Sundrum graviton with coupling k/MPl=0.1 is excluded at 95 % confidence level for masses below 2.16 TeV. Limits on the other models are also presented, including Technicolor and Minimal Z′ Models

Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at √s = 7 TeV with the ATLAS detector

This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of √s = 7 TeV;{\rm Te}{\rm V}$and correspond to an integrated luminosity of$4.6\;{\rm f}{{{\rm b}}^{-1}}$. The measurement is performed by reconstructing the boosted W or Z bosons in single jets. The reconstructed jet mass is used to identify the W and Z bosons, and a jet substructure method based on energy cluster information in the jet centre-of-mass frame is used to suppress the large multi-jet background. The cross-section for events with a hadronically decaying W or Z boson, with transverse momentum${{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}$and pseudorapidity$|\eta |\lt 1.9$, is measured to be${{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques

Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector

A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or τ lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, φ, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan β in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN