Serum 25-hydroxyvitamin D is inversely associated with body mass index in cancer

<p>Abstract</p> <p>Background</p> <p>The association between vitamin D deficiency and obesity in healthy populations and different disease states remains unsettled with studies reporting conflicting findings. Moreover, current dietary recommendations for vitamin D do not take into account a person's body mass index (BMI). We investigated the relationship between serum 25-hydroxy-vitamin D [25(OH)D] and BMI in cancer.</p> <p>Methods</p> <p>A consecutive case series of 738 cancer patients. Serum 25(OH)D was measured at presentation to the hospital. The cohort was divided into 4 BMI groups (underweight: <18.5, normal weight: 18.5-24.9, overweight: 25-29.9, and obese: >30.0 kg/m²). Mean 25(OH)D was compared across the 4 BMI groups using ANOVA. Linear regression was used to quantify the relationship between BMI and 25(OH)D.</p> <p>Results</p> <p>303 were males and 435 females. Mean age at diagnosis was 55.6 years. The mean BMI was 27.9 kg/m²and mean serum 25(OH)D was 21.9 ng/ml. Most common cancers were lung (134), breast (131), colorectal (97), pancreas (86) and prostate (45). Obese patients had significantly lower serum 25(OH)D levels (17.9 ng/ml) as compared to normal weight (24.6 ng/ml) and overweight (22.8 ng/ml) patients; p < 0.001. After adjusting for age, every 1 kg/m²increase in BMI was significantly associated with 0.42 ng/ml decline in serum 25(OH)D levels.</p> <p>Conclusions</p> <p>Obese cancer patients (BMI >= 30 kg/m²) had significantly lower levels of serum 25(OH)D as compared to non-obese patients (BMI <30 kg/m²). BMI should be taken into account when assessing a patient's vitamin D status and more aggressive vitamin D supplementation should be considered in obese cancer patients.</p

Health Behavior, Health Promotion, and the Transition to Parenthood : Insights from Research in Health Psychology and Behavior Change

The transition to parenthood represents a period of considerable change. Much of the change is positive as parents experience the inherent emotional and social benefits of becoming a parent. However, it is also a period of considerable challenge and stress, which can have deleterious effects on health and well-being. Increased demands of caring for an infant can lead to loss of sleep, limited ‘leisure’ time, restrictions on social life, and difficulties in managing ‘work-life’ balance. In addition, the disruption and time demand lead to parents ‘falling out’ of health habits. Parents also have new responsibilities to care for the health of their child, and socialize them into healthy habits. Identifying strategies parents can adopt to initiate and maintain health behaviors during the transition to parenthood may be important means to increase their physical and psychological health. In addition, providing parents with the motivation and means to socialize their children into health behaviors is an important health promotion goal. The present chapter reviews the key behavioral health issues experienced by adults in the transition to parenthood, focusing on behaviors that will promote good physical and psychological health, and the imperative of adopting behaviors that will promote and maintain the health of their child. Research on the application of social cognitive theories to predict and understand health behavior in parents and their children will be reviewed. Based on this research, theory-based behavior change strategies aimed at promoting health behaviors in parents in the transition to parenthood and their children will be identified.peerReviewe