Pickup ion measurements by MAVEN: A diagnostic of photochemical oxygen escape from Mars

A key process populating the oxygen exosphere at Mars is the dissociative recombination of ionospheric O 2 + , which produces fast oxygen atoms, some of which have speeds exceeding the escape speed and thus contribute to atmospheric loss. Theoretical studies of this escape process have been carried out and predictions made of the loss rate; however, directly measuring the escaping neutral oxygen is difficult but essential. This paper describes how energetic pickup ion measurements to be made near Mars by the SEP (Solar Energetic Particle) instrument on board the MAVEN (Mars Atmosphere and Volatile EvolutioN) spacecraft can be used to constrain models of photochemical oxygen escape. In certain solar wind conditions, neutral oxygen atoms in the distant Martian exosphere that are ionized and picked up by the solar wind can reach energies high enough to be detected near Mars by SEP. Key Points Photochemical hot oxygen escape rate at Mars is predicted Martian exospheric neutral oxygen model is constructed Pickup ion fluxes measured by SEP will constrain neutral oxygen escape from MarsPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108375/1/grl51888.pd

Constituting We the People

We study roles of the thermosphere and exosphere on the Martian ionospheric structure and ion escape rates in the process of the solar wind-Mars interaction. We employ a four-species multifluid MHD (MF-MHD) model to simulate the Martian ionosphere and magnetosphere. The $cold$ thermosphere background is taken from the Mars Global Ionosphere Thermosphere Model (M-GITM) and the $hot$ oxygen exosphere is adopted from the Mars exosphere Monte Carlo model - Adaptive Mesh Particle Simulator (AMPS). A total of four cases with the combination of 1D (globally averaged) and 3D thermospheres and exospheres are studied. The ion escape rates calculated by adopting 1D and 3D atmospheres are similar; however, the latter are required to adequately reproduce MAVEN ionospheric observations. In addition, our simulations show that the 3D hot oxygen corona plays an important role in preventing planetary molecular ions (O$_2^+$ and CO$_2^+$) escaping from Mars, mainly resulting from the mass loading of the high-altitude exospheric O$^+$ ions. The $cold$ thermospheric oxygen atom, however, is demonstrated to be the primary neutral source for O$^+$ ion escape during the relatively weak solar cycle 24.Comment: 21 pages, 10 figures, 4 tables, accepted for publication in Journal of Geophysical Research-Space Physic

Three‐dimensional study of Mars upper thermosphere/ionosphere and hot oxygen corona: 2. Solar cycle, seasonal variations, and evolution over history

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95238/1/jgre2686.pd

Involvement of Hepatic Innate Immunity in Alcoholic Liver Disease

Excessive alcohol consumption is one of the critical causative factors leading to alcoholic liver disease (ALD). ALD is characterized by a wide spectrum of liver damage, ranging from simple uncomplicated liver steatosis (fatty liver) to steatohepatitis and liver fibrosis/cirrhosis. It has been believed that the obvious underlying cause for ALD is due to hepatocyte death induced by alcohol itself. However, recent sparkling studies have shown that diverse immune responses contribute to ALD because liver is enriched with numerous immune cells. Especially, a line of evidence has suggested that innate immune cells such as Kupffer cells and natural killer (NK)/NKT cells are significantly involved in the pathogenesis of ALD via production of pro-inflammatory cytokines and other mediators. Indeed, more interestingly, hepatic stellate cells (HSCs), known as a major cell inducing liver steatosis and fibrosis, can be killed by liver NK cells, which could be suppressed by chronic alcohol consumption. In this review, with the view of liver as predominant innate immune organ, we describe the pathogenesis of ALD in which what roles of innate immune cells are and how they are interacting with HSCs

Composition of Titan's ionosphere

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94758/1/grl21212.pd

Deregulation of Sucrose-Controlled Translation of a bZIP-Type Transcription Factor Results in Sucrose Accumulation in Leaves

Sucrose is known to repress the translation of Arabidopsis thaliana AtbZIP11 transcript which encodes a protein belonging to the group of S (S - stands for small) basic region-leucine zipper (bZIP)-type transcription factor. This repression is called sucrose-induced repression of translation (SIRT). It is mediated through the sucrose-controlled upstream open reading frame (SC-uORF) found in the AtbZIP11 transcript. The SIRT is reported for 4 other genes belonging to the group of S bZIP in Arabidopsis. Tobacco tbz17 is phylogenetically closely related to AtbZIP11 and carries a putative SC-uORF in its 5′-leader region. Here we demonstrate that tbz17 exhibits SIRT mediated by its SC-uORF in a manner similar to genes belonging to the S bZIP group of the Arabidopsis genus. Furthermore, constitutive transgenic expression of tbz17 lacking its 5′-leader region containing the SC-uORF leads to production of tobacco plants with thicker leaves composed of enlarged cells with 3–4 times higher sucrose content compared to wild type plants. Our finding provides a novel strategy to generate plants with high sucrose content

Cooperation among cancer cells: applying game theory to cancer

Cell cooperation promotes many of the hallmarks of cancer via the secretion of diffusible factors that can affect cancer cells or stromal cells in the tumour microenvironment. This cooperation cannot be explained simply as the collective action of cells for the benefit of the tumour because non-cooperative subclones can constantly invade and free-ride on the diffusible factors produced by the cooperative cells. A full understanding of cooperation among the cells of a tumour requires methods and concepts from evolutionary game theory, which has been used successfully in other areas of biology to understand similar problems but has been underutilized in cancer research. Game theory can provide insights into the stability of cooperation among cells in a tumour and into the design of potentially evolution-proof therapies that disrupt this cooperation