2,426 research outputs found
A Study on the Generality of Neural Network Structures for Monocular Depth Estimation
Monocular depth estimation has been widely studied, and significant
improvements in performance have been recently reported. However, most previous
works are evaluated on a few benchmark datasets, such as KITTI datasets, and
none of the works provide an in-depth analysis of the generalization
performance of monocular depth estimation. In this paper, we deeply investigate
the various backbone networks (e.g.CNN and Transformer models) toward the
generalization of monocular depth estimation. First, we evaluate
state-of-the-art models on both in-distribution and out-of-distribution
datasets, which have never been seen during network training. Then, we
investigate the internal properties of the representations from the
intermediate layers of CNN-/Transformer-based models using synthetic
texture-shifted datasets. Through extensive experiments, we observe that the
Transformers exhibit a strong shape-bias rather than CNNs, which have a strong
texture-bias. We also discover that texture-biased models exhibit worse
generalization performance for monocular depth estimation than shape-biased
models. We demonstrate that similar aspects are observed in real-world driving
datasets captured under diverse environments. Lastly, we conduct a dense
ablation study with various backbone networks which are utilized in modern
strategies. The experiments demonstrate that the intrinsic locality of the CNNs
and the self-attention of the Transformers induce texture-bias and shape-bias,
respectively.Comment: Accepted in TPAM
Tracing Recent Star Formation of Red Early-type Galaxies out to 1
We study the mid-infrared (IR) excess emission of early-type galaxies (ETGs)
on the red-sequence at 1 using a spectroscopic sample of galaxies in the
fields of Great Observatories Origins Deep Survey (GOODS). In the mass-limited
sample of 1025 galaxies with 10 and
, we identify 696 24 m detected (above the
5) galaxies and find them to have a wide range of NUV- and -[12
m] colors despite their red optical colors. Even in the sample of
very massive ETGs on the red sequence with 10
, more than 18% show excess emission over the photospheric emission
in the mid-IR. The combination with the results of red ETGs in the local
universe suggests that the recent star formation is not rare among quiescent,
red ETGs at least out to if the mid-IR excess emission results from
intermediate-age stars or/and from low-level ongoing star formation. Our
colorcolor diagram including near-UV and mid-IR emissions are efficient not
only for identifying ETGs with recent star formation, but also for
distinguishing quiescent galaxies from dusty star-forming galaxies.Comment: 25 pages, 9 figures, accepted for publication in Ap
Optical Images and Source Catalog of AKARI North Ecliptic Pole Wide Survey Field
We present the source catalog and the properties of the , and
band images obtained to support the {\it AKARI} North Ecliptic Pole Wide
(NEP-Wide) survey. The NEP-Wide is an {\it AKARI} infrared imaging survey of
the north ecliptic pole covering a 5.8 deg area over 2.5 -- 6 \micron
wavelengths. The optical imaging data were obtained at the Maidanak Observatory
in Uzbekistan using the Seoul National University 4k 4k Camera on the
1.5m telescope. These images cover 4.9 deg where no deep optical imaging
data are available. Our , and band data reach the depths of
23.4, 23.1, and 22.3 mag (AB) at 5, respectively. The
source catalog contains 96,460 objects in the band, and the astrometric
accuracy is about 0.15\arcsec at 1 in each RA and Dec direction.
These photometric data will be useful for many studies including identification
of optical counterparts of the infrared sources detected by {\it AKARI},
analysis of their spectral energy distributions from optical through infrared,
and the selection of interesting objects to understand the obscured galaxy
evolution.Comment: 39 pages, 12 figure
Inflammation-induced Id2 promotes plasticity in regulatory T cells
T(H)17 cells originating from regulatory T (T-reg) cells upon loss of the T-reg-specific transcription factor Foxp3 accumulate in sites of inflammation and aggravate autoimmune diseases. Whether an active mechanism drives the generation of these pathogenic 'ex-Foxp3 T(H)17' cells, remains unclear. Here we show that pro-inflammatory cytokines enhance the expression of transcription regulator Id2, which mediates cellular plasticity of T-reg into 'ex-Foxp3' T(H)17 cells. Expression of Id2 in in vitro differentiated iT(reg) cells reduces the expression of Foxp3 by sequestration of the transcription activator E2A, leading to the induction of T(H)17-related cytokines. T-reg-specific ectopic expression of Id2 in mice significantly reduces the T-reg compartment and causes immune dysregulation. Cellular fate-mapping experiments reveal enhanced T-reg plasticity compared to wild-type, resulting in exacerbated experimental autoimmune encephalomyelitis pathogenesis or enhanced anti-tumor immunity. Our findings suggest that controlling Id2 expression may provide a novel approach for effective T-reg cell immunotherapies for both autoimmunity and cancer.11sciescopu
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AKARI observation of early-type galaxies in Abell 2218
We describe the AKARI InfraRed Camera (IRC) imaging observation of early-type galaxies (ETGs) in A2218 at z ≅ 0.175. With the imaging capability at 11 and 15 μm, we investigate mid-infrared (MIR) properties of ETGs in the cluster environment. Among our flux-limited sample of 22 optical red sequence ETGs, we find that more than 50% have MIR-excess emission, and the most likely cause of the MIR excess is the circumstellar dust emission from asymptotic giant branch (AGB) stars. The MIR-excess galaxies reveal a wide spread in N3-S11 (3 and 11 μm) colors, indicative of a significant spread (2–11 Gyr) in the mean ages of stellar populations. They are also preferentially located in the outer region, suggesting the environment dependence of MIR-excess ETGs over an area out to a half virial radius
The mid-infrared view of red sequence galaxies in Abell 2218 with <i>AKARI</i>
We present the AKARI Infrared Camera (IRC) imaging observation of early-type galaxies (ETGs) in A2218 at z ~ 0.175. Mid-infrared (MIR) emission from ETGs traces circumstellar dust emission from asymptotic giant branch (AGB) stars or/and residual star formation. Including the unique imaging capability at 11 and 15 μm, our AKARI data provide an effective way to investigate MIR properties of ETGs in the cluster environment. Among our flux-limited sample of 22 red sequence ETGs with precise dynamical and line strength measurements (less than 18 mag at 3 μm), we find that at least 41% have MIR-excess emission. The N3 – S11 versus N3 (3 and 11 μm) color-magnitude relation shows the expected blue sequence, but the MIR-excess galaxies add a red wing to the relation especially at the fainter end. A spectral energy distribution analysis reveals that the dust emission from AGB stars is the most likely cause of the MIR excess, with a low level of star formation being the next possible explanation. The MIR-excess galaxies show a wide spread of N3 – S11 colors, implying a significant spread (2-11 Gyr) in the estimated mean ages of stellar populations. We study the environmental dependence of MIR-excess ETGs over an area out to a half virial radius (~1 Mpc). We find that the MIR-excess ETGs are preferentially located in the outer region. From this evidence, we suggest that the fainter, MIR-excess ETGs have just joined the red sequence, possibly due to the infall and subsequent morphological/spectral transformation induced by the cluster environment
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Immunomodulatory effect of water soluble extract separated from mycelium of Phellinus linteus on experimental atopic dermatitis
Background: Complementary and alternative medicine (CAM) is becoming a popular treatment for modulating diverse immune disorders. Phellinus linteus (P. linteus) as one of the CAMs has been used to modulate cancers, inflammation and allergic activities. However, little evidence has been shown about its underlying mechanism of action by which it exerts a beneficial role in dermatological disease in vivo. In this study, we examined the immunomodulatory effects of P. linteus on experimental atopic dermatitis (AD) and elucidated its action mechanism. Methods: The immunomodulatory effect of total extract of P. linteus on IgE production by human myeloma U266B1 cells was measured by ELISA. To further identify the effective components, P. linteus was fractionated into methanol soluble, water soluble and boiling water soluble extracts. Each extract was treated to U266B1 cells and primary B cells to compare their inhibitory effects on IgE secretion. To test the in vivo efficacy, experimental atopic dermatitis (AD) was established by alternative treatment of DNCB and house dust mite extract into BALB/c mice. Water soluble extract of P. linteus (WA) or ceramide as a positive control were topically applied to ears of atopic mouse every day for 2 weeks and progression of the disease was estimated by the following criteria: (a) ear thickness, clinical score, (b) serum total IgE, IgG and mite specific IgE level by ELSIA, (c) histological examination of ear tissue by H&E staining and (d) cytokine profile of total ear cells and CD4+ T cells by real time PCR and ELSIA. Results: Treatment of total extracts of P. linteus to U266B1 inhibited IgE secretion. Among the diverse extracts of P. linteus, water soluble extract of P. linteus (WA) significantly reduced the IgE production in primary B cells and B cell line U266B1. Moreover, treatment of WA reduced AD symptoms such as ear swelling, erythema, and dryness and decreased recruitment of lymphocyte into the inflamed site. Interestingly WA treatment significantly reduced IgE level without affecting IgG levels and also down-regulated the levels of pathogenic cytokines (IL-4, IL-13, IL-12 and IFN-γ) and chemokines (CCL17 and CCL22) involved in AD development. Conclusions: Our study indicates that protective effect of water soluble extract of P. linteus in atopic dermatitis is mediated by inhibiting IgE production and expression of AD associated pathogenic cytokines as well as chemokines, suggesting the beneficial effect of P. linteus to modulate allergic skin disease
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