Rectal Cancer Diagnosed after Cesarean Section in Which High Microsatellite Instability Indicated the Presence of Lynch Syndrome

We report a case of rectal cancer with microsatellite instability (MSI) that probably resulted from Lynch syndrome and that was diagnosed after Cesarean section. The patient was a 28-year-old woman (gravid 1, para 1) without a significant medical history. At 35 gestational weeks, vaginal ultrasonography revealed a 5 cm tumor behind the uterine cervix, which was diagnosed as a uterine myoma. The tumor gradually increased in size and blocked the birth canal, resulting in the patient undergoing an emergency Cesarean section. Postoperatively, the tumor was diagnosed as rectal cancer with MSI. After concurrent chemoradiation therapy, a lower anterior resection was performed. The patient’s family history revealed she met the criteria of the revised Bethesda guidelines for testing the colorectal tumor for MSI. Testing revealed that the tumor did indeed show high MSI and, combined with the family history, suggested this could be a case of Lynch syndrome. Our findings emphasize the importance of considering the possibility of Lynch syndrome in pregnant women with colorectal cancer, particularly those with a family history of this condition. We suggest that the presence of Lynch syndrome should also be considered for any young woman with endometrial, ovarian, or colorectal cancer

Rectal Cancer Diagnosed after Cesarean Section in Which High Microsatellite Instability Indicated the Presence of Lynch Syndrome

We report a case of rectal cancer with microsatellite instability (MSI) that probably resulted from Lynch syndrome and that was diagnosed after Cesarean section. The patient was a 28-year-old woman (gravid 1, para 1) without a significant medical history. At 35 gestational weeks, vaginal ultrasonography revealed a 5 cm tumor behind the uterine cervix, which was diagnosed as a uterine myoma. The tumor gradually increased in size and blocked the birth canal, resulting in the patient undergoing an emergency Cesarean section. Postoperatively, the tumor was diagnosed as rectal cancer with MSI. After concurrent chemoradiation therapy, a lower anterior resection was performed. The patient’s family history revealed she met the criteria of the revised Bethesda guidelines for testing the colorectal tumor for MSI. Testing revealed that the tumor did indeed show high MSI and, combined with the family history, suggested this could be a case of Lynch syndrome. Our findings emphasize the importance of considering the possibility of Lynch syndrome in pregnant women with colorectal cancer, particularly those with a family history of this condition. We suggest that the presence of Lynch syndrome should also be considered for any young woman with endometrial, ovarian, or colorectal cancer

温熱性発汗特性を考慮した椅座時の平均皮膚表面温度の予測

application/pdfSkin temperature has been recognized as a major factor in judging the thermal sensation. Analysing data reported on sweating, whose rate seemed to be represented by skin temperature, provided that the thermal equilibrium had been attained. This paper, first, describes about the results of experiments conducted on thermal sweating of sedentary subjects, in which the linear relationship between the mean skin temperature and sweating rate was confirmed. Applying this relationship into the heat balance equation, a simple equation for predicting the mean skin temperature was introduced as an index of human response to the thermal environment

運動時の温熱性発汗特性と平均皮膚表面温度の予測

application/pdfAnalysing data reported on sweating, it seemed that thermal sweating rate was proportional to mean skin temperature, provided that the thermal equilibrium had been attained. This paper, first, described about the results of experiments conducted on thermal sweating of subjects under bicycle ergometer exercise, in which the linear relationship between the mean skin temperature and sweating rate was confirmed. Applying this relationship into the heat balance equation, a simple equation for predicting the mean skin temperature was introduced as an index of human response to the thermal environment