Dataset for Effect of matrix solidification on the structure formation in electromagnetic suspensions

Dataset from numerical simulations describing the structure formation in suspensions with electromagnetically active particles in an external field, as described in detail in the paper Konstantinos Manikas, Markus Hütter, Patrick D. Anderson: Effect of matrix solidification on the structure formation in electromagnetic suspensions. Appl. Phys. A, 128: 709 (11 pages), 2022. DOI: 10.1007/s00339-022-05844-y WWW: https://doi.org/10.1007/s00339-022-05844-y which should be cited whenever this dataset is used. The data compiled here is the basis for figures 4, 5, and 6 in that paper

Micro-topographies induce epigenetic reprogramming and quiescence in human mesenchymal stem cells

Biomaterials can control cell and nuclear morphology. Since the shape of the nucleus influences chromatin architecture, gene expression, and cell identity, surface topography can control cell phenotype. This study explores how surface topography influences nuclear morphology, histone modifications, and expression of histone-associated proteins through advanced histone mass spectrometry and microarray analysis. We found that nuclear confinement is associated with loss of both histone acetylation and nucleoli abundance, while pathway analysis revealed a substantial reduction in gene expression associated with chromosome organization. In light of previous observations where we found a decrease in proliferation and metabolism induced by micro-topographies, we connect these findings with a quiescent phenotype in mesenchymal stem cells, as further shown by a reduction of ribosomal proteins and the maintenance of multipotency on micro-topographies after long-term culture conditions. Furthermore, this influence of micro-topographies on nuclear morphology and proliferation was reversible, as shown by a full return of proliferation when re-cultured on a flat surface. Our findings provide novel insights on how biophysical signaling influences nuclear organization and subsequent cellular phenotype

Microfluidic Models of Metastasis: In vitro approaches to study the tumor microenvironment - supplementary design and video files

Design files of microfluidic and peripheral devices designed in the PhD thesis "Microfluidic Models of Metastasis: In vitro approaches to study the tumor microenvironment" of Jelle J.F. Sleeboom, and 10 experimental videos. A catalogue record of the thesis is available from the Eindhoven University of Technology Library. ISBN: 978-90-386-5104-

Source data for the publication: Metachronal micro‑Cilia for On-Chip Integrated Pumps and Climbing Robots

This data set contains the source data of the publication: Zhang, S., Cui, Z., Wang, Y. & Toonder, J.M.J. den (2021). Metachronal micro-cilia for on-chip integrated pumps and climbing robots. ACS Appl. Mater. Interfaces. DOI: https://doi.org/10.1021/acsami.1c03009. This paper demonstrates a simple method to realize metachronal microscopic magnetic artificial cilia (microMAC) through control over the paramagnetic particle distribution within the microMAC based on their tendency to align with an applied magnetic field. Actuated by a 2D rotating uniform magnetic field, the metachronal microMAC enable strong microfluidic pumping and soft robot locomotion. The metachronal micro MAC induce twice the pumping efficiency and 3 times the locomotion speed of synchronously moving microMAC. The ciliated soft robots show an unprecedented slope climbing ability and they display strong cargo-carrying capacity in both dry and wet conditions. The data are experimentally obtained with methods described in the publication

Data underlying the publication "Notch signaling regulates strain-mediated phenotypic switching of vascular smooth muscle cells"

The data and resulting publication show the role of Notch signaling in regulating strain-mediated phenotypic switching of vascular smooth muscle cells. The dataset consists of custom-built scripts for strain analysis, stretch quantification data, immunofluorescence staining and real-time polymerase chain reaction data

Data underlying the publication: "Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis"

A combination of experiments and modeling. The data underlies the publication: "Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis