3 research outputs found
Validation of prognostic models: challenges and opportunities
Multivariable prognostic models combine several
characteristics to provide predictions for individual patients.
Prognostic models can be applied in research and clinical
practice, for instance to assist clinicians with decisions
regarding treatment choices or informing patients and
family members on prognosis (1). Before application in
clinical practice, prognostic models should be validated
to judge their generalizability. Although guidelines have
been proposed to improve development and reporting of
prognostic models, a majority of the published models is
not thoroughly validated (1,2). In this viewpoint, we focus
on design and analysis of validation
Prediction of Global Functional Outcome and Post-Concussive Symptoms after Mild Traumatic Brain Injury: External Validation of Prognostic Models in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study
The majority of traumatic brain injuries (TBIs) are categorized as mild, according to a baseline Glasgow Coma Scale (GCS) score of 13-15. Prognostic models that were developed to predict functional outcome and persistent post-concussive symptoms (PPCS) after mild TBI have rarely been externally validated. We aimed to externally validate models predicting 3-12-month Glasgow Outcome Scale Extended (GOSE) or PPCS in adu
Prognostic Research in Traumatic Brain Injury
Prognostic assessment in traumatic brain injury (TBI) is embedded deeply in clinical care. Considering the limitations of current prognostic indicators, there is increasing interest in understanding the role of new biomarkers, and in finding other prognostic indicators of long-term outcomes following TBI. New prognostic indicators may result in the development of more accurate prediction models that could be useful for both risk stratification and clinical decision making. We aimed to review methodological issues and provide tentative guidelines for prognostic research in TBI. Prognostic factor research focuses on the role of a specific patient or disease-related characteristic in relation to outcome. Typically, univariable relations of the prog