Synthesis, Characterization and Biological Evaluationof Thiazolopyrimidine Derivatives

Different substituted diesters of thiazolopyrimidine were prepared by the treatment of 3,4 dihydropyrimidine2-thione with á-haloesters using ethanol under reflux condition affording 71–85% yield. IR, 1HNMR, 13CNMR and elemental analyses were used for the characterization of these compounds. The crystal and molecular structure of one of the product, 5-phenyl-3,7-dimethyl-5H- hiazolo[3,2-a]pyrimidine-2,6- dicarboxylic acid diethyl ester (3e) was verified by single crystal X-ray diffraction method. The antimicrobial activity was evaluated against four bacterial strains and one fungal species. Few of the derivatives exhibited antibacterial and antifungal activities

Synthesis and Crystal Structure Analysis of 2-(Fluorobenzyl)-6-(4-Nitrophenyl) Imidazo[2,1-b][1,3,4]Thiadiazole

Preparation of 2-(4-fluorobexzyl)-6-(4-nitrophenyl)imidazo[2,1-b][1,3,4]thiadiazole is described and its crystal structure is discussed. The compound crystallizes in the monoclinic space group C2/c with a = 39.941(6) Å, b = 5.698(2) Å, c = 13.272(5) Å β = 90.880°, V = 3020(2) Å3, z = 8. The crystal structure is stabilized by weak intermolecular C-H…N,C-H…O,C-H…S, and C-H…F interactions

3-{[6-(4-Chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]methyl}-1,2-benzoxazole

In the title compound, C18H11ClN4OS, the benzisoxazole and imidazothiadiazole rings are inclined at an angle of 23.81 (7)degrees with respect to each other. The imidazothiadiazole and chlorophenyl rings make a dihedral angle of 27.34 (3)degrees. In the crystal, intermolecular C-H center dot center dot center dot N interactions generate a chain along the c axis and C-H center dot center dot center dot O interactions form centrosymmetric dimers resulting in an R-2(2)(26) graph-set motif. Moreover, the C-H center dot center dot center dot N and S center dot center dot center dot N [3.206 (4) angstrom] interactions links the molecules into R(7) ring motifs. The packing is further stabilized by pi-pi stacking interactions between the thiadiazole rings with a shortest centroid-centroid distance of 3.497 (3) angstrom. In addition, C-H center dot center dot center dot pi interactions are observed in the crystal structur

Synthesis, spectroscopic and crystal structure analysis of 2-amino-5,5-dimethyl-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile and-3-carboxamide

The preparation of 2-amino-5,5-dimethyl-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide via the intermediate 2-amino-5,5-dimethyl-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile is described, along with details of the crystal structure analysis of both compounds

Synthesis, Spectroscopy and Crystal Structure of 2‐Ethyl‐6‐(4‐nitrophenyl)imidazo[2,1‐b] [1,3,4]thiadiazole‐5‐carbaldehyde.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF

Synthesis, spectroscopic and crystal structure analysis of a compound with pharmocophoric substituent: 2-cyclohexyl-6-(2-oxo-2H-chromen-3-yl)- imidazo[2,1-b] [1,3,4]thiadiazole-5-carbaldehyde

Imidazo[2,1-b][1,3,4] thiadiazole derivatives are significant for their various pharmacological properties. This paper reports the synthesis and structure of one of them, 2-cyclohexyl-6-(2-oxo-2H-chromen-3-yl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde. The compound crystallizes in the monoclinic space group P21/c with a=17.316(3)Å, b=6.5420(9)Å, c =17.056(3)Å, β=112.909(2)°, V=1779.7(4)Å3, z=4. The, Imidazo[2,1-b][1,3,4] thiadiazole and the coumarin ring systems are each planar but inclined at an angle of 48.14(2)° towards each other. The crystal structure is stabilized by C–H … O interactions

Synthesis, characterization and biological evaluation of thiazolopyrimidine derivatives

Different substituted diesters of thiazolopyrimidine were prepared by the treatment of 3,4 dihydropyrimidine2-thione with α-haloesters using ethanol under reflux condition affording 71-85 yield. IR, 1HNMR, 13CNMR and elemental analyses were used for the characterization of these compounds. The crystal and molecular structure of one of the product, 5-phenyl-3,7-dimethyl-5H-thiazolo3,2-apyrimidine-2,6-dicarboxylic acid diethyl ester (3e) was verified by single crystal X-ray diffraction method. The antimicrobial activity was evaluated against four bacterial strains and one fungal species. Few of the derivatives exhibited antibacterial and antifungal activities. © Indian Academy of Sciences

2-Ethyl-6-(4-methoxy-phen-yl)imidazo2,1-b1,3,4thia-diazole-5- carbaldehyde

In the title compound, C14H13N3O2S, the imidazothia­diazole ring system and the methoxy­phenyl ring are not coplanar, having an angle of 31.60 (7)° between their mean planes. In the crystal structure, inter­molecular C-H...O hydrogen-bond inter­actions link the mol­ecules into dimers and [pi]-[pi] stacking inter­actions reinforce the crystal cohesion

Synthesis and crystal structure of 2-(4-Fluorobenzyl)-6-phenylimidazo2,1- b1,3,4thiadiazole-5-carbaldehyde

The crystal and molecular structure of 2-(4-fluoro-benzyl)-6-phenyl- imidazo2,1-b1,3,4thiadiazole-5-carbaldehyde is described. The compound crystallizes in the monoclinic space group P21/n with a=7.419(3), à b=8.287(3), à c=25.734(10)à , β=91.686(8)°, V=1,581.6(10)à 3, z=4. The crystal structure is stabilized by intermolecular C-HN, C-HO, and C-HF interactions. Copyright © Taylor & Francis Group, LLC