Gravitational Charged Perfect Fluid Collapse in Friedmann Universe Models

This paper is devoted to study the gravitational charged perfect fluid collapse in the Friedmann universe models with cosmological constant. For this purpose, we assume that the electromagnetic field is so weak that it does not introduce any distortion into the geometry of the spacetime. The results obtained from the junction conditions between the Friedmann and the Reissner-Nordstr$\ddot{o}$m de-Sitter spacetimes are used to solve the field equations. Further, the singularity structure and mass effects of the collapsing system on time difference between the formation of apparent horizons and singularity have been studied. This analysis provides the validity of Cosmic Censorship Hypothesis. It is found that the electric field affects the area of apparent horizons and their time of formation.Comment: 17 pages, accepted for publication in Astrophys. Space Sc

Immune responses to Plasmodium falciparum–merozoite surface protein 1 (MSP1) antigen, II. Induction of parasite-specific immunoglobulin G in unsensitized human B cells after in vitro T-cell priming with MSP119

A baculovirus recombinant antigen corresponding to the C-terminal 19 000 MW fragment of Plasmodium falciparum merozoite surface protein 1 (MSP119), has been used to prime T cells from individuals with no previous exposure to malaria, to provide help for the induction of a parasite specific antibody response in vitro. Although MSP119 alone could induce a small but detectable T-cell response, which included interleukin-4 (IL-4) secretion, this response was significantly increased by the presence of IL-2. In addition, IL-4 was shown to synergize with IL-2 for the induction of antigen-specific T-cell responses. If interferon-γ (IFN-γ), IL-12, or neutralizing anti-IL-4 antibody was present at the time of priming, the T-cell responses were abolished. Parasite-specific immunoglobulin G (IgG) could be detected after secondary restimulation with MSP119, IL-10 and anti-CD40 monoclonal antibody in cultures containing MSP119 primed T cells, autologous B cells, IL-2 and IL-4. No antibody was secreted in the absence of primed T cells in this B-cell culture assay. These data show that recombinant MSP119, a leading malaria vaccine candidate, can prime non-immune human lymphocytes under defined in vitro experimental conditions, which include regulatory cytokines and/or other costimulatory molecules. This is a complementary approach for exploring immunogenic mechanisms of potential vaccine candidates such as P. falciparum antigens in humans