Особенности пролиферативных процессов при инвертированной папилломе и раке полости носа и околоносовых пазух

The article presents the results of investigation on detection of criterions of cell changing in inverted papilloma and carcinoma of the nasal cavity mucose and paranasal sinuses. Proliferative process in different layers of nasal cavity mucose and paranasal sinuses was examined by immunohistochemical method. It was established that the most important for diagnosis of inverted papilloma is proportion of cells in basal and parabasall layers. Carcinoma is characterized by distribution of positive painted cells from the basal membrane to the central zone of tumors.В статье представлены результаты исследования, направленного на выявление критериев изменений пролиферации клеток эпителия при инвертированной папилломе и раке слизистой оболочки полости носа и околоносовых пазух. С помощью иммуногистохимического метода была оценена пролиферация в различных слоях эпителия слизистой оболочки полости носа и околоносовых пазух. Установлено, что наиболее важным для диагностики инвертированных папиллом является соотношение пролиферирующих клеток в базальном и парабазальном клеточных слоях. В плоскоклеточном раке отмечена высокая пролиферативная активность клеток, архитектоника ткани была полностью нарушена и деление эпителия на слои практически отсутствовало. Положительно окрашенные клетки распределялись равномерно от базального слоя до центральной зоны опухоли

Study of doubly strange systems using stored antiprotons

Bound nuclear systems with two units of strangeness are still poorly known despite their importance for many strong interaction phenomena. Stored antiprotons beams in the GeV range represent an unparalleled factory for various hyperon-antihyperon pairs. Their outstanding large production probability in antiproton collisions will open the floodgates for a series of new studies of systems which contain two or even more units of strangeness at the P‾ANDA experiment at FAIR. For the first time, high resolution γ-spectroscopy of doubly strange ΛΛ-hypernuclei will be performed, thus complementing measurements of ground state decays of ΛΛ-hypernuclei at J-PARC or possible decays of particle unstable hypernuclei in heavy ion reactions. High resolution spectroscopy of multistrange Ξ−-atoms will be feasible and even the production of Ω−-atoms will be within reach. The latter might open the door to the |S|=3 world in strangeness nuclear physics, by the study of the hadronic Ω−-nucleus interaction. For the first time it will be possible to study the behavior of Ξ‾+ in nuclear systems under well controlled conditions

Determination of integral cross sections of

The results of 3H production in Al foil monitors (∼ 59 mg/cm2 thickness) are presented. These foils have been irradiated in 15×15 mm polyethylene bags of ∼ 14 mg/cm2 thickness together with foils of Cr (∼ 395 mg/cm2 thickness) and 56Fe (∼ 332 mg/cm2 thickness) by protons of different energies in a range of 0.04 – 2.6 GeV. The diameters of all the foils were 10.5 mm. The irradiations were carried out at the ITEP accelerator U–10 under the ISTC Project # 3266 in 2006–2009. 3H has been extracted from Al foils using an A307 Sample Oxidizer. An ultra low level liquid scintillation spectrometer Quantulus1220 was used to measure the 3H β–spectra and the SpectraDec software package was applied for spectra processing, deconvolution and 3H activity determination. The values of the Al (p, x)3H reaction cross sections obtained in these experiments are compared with data measured at other labs and with results of simulations by the MCNP6 radiation transport code using the CEM03.03 event generator

Bi-functional sterically hindered phenol lipid-based delivery systems as potential multi-target agents against Alzheimer's disease: Via an intranasal route

© The Royal Society of Chemistry. New lipid-based nanomaterials and multi-target directed ligands (MTDLs) based on sterically hindered phenol, containing a quaternary ammonium moiety (SHP-s-R, with s = 2,3) of varying hydrophobicity (R = CH2Ph and CnH2n+1, with n = 8, 10, 12, 16), have been prepared as potential drugs against Alzheimer's disease (AD). SHP-s-R are inhibitors of human cholinesterases with antioxidant properties. The inhibitory potency of SHP-s-R and selectivity ratio of cholinesterase inhibition were found to significantly depend on the length of the methylene spacer (s) and alkyl chain length. The compound SHP-2-16 showed the best IC50 for human AChE and the highest selectivity, being 30-fold more potent than for human BChE. Molecular modeling of SHP-2-16 binding to human AChE suggests that this compound is a dual binding site inhibitor that interacts with both the peripheral anionic site and catalytic active site. The relationship between self-assembly parameters (CMC, solubilization capacity, aggregation number), antioxidant activity and a toxicological parameter (hemolytic action on human red blood cells) was investigated. Two sterically hindered phenols (SHP-2-Bn and SHP-2-R) were loaded into L-a-phosphatidylcholine (PC) nanoparticles by varying the SHP alkyl chain length. For the brain AChE inhibition assay, PC/SHP-2-Bn/SHP-2-16 nanoparticles were administered to rats intranasally at a dose of 8 mg kg-1. The Morris water maze experiment showed that scopolamine-induced AD-like dementia in rats treated with PC/SHP-2-Bn/SHP-2-16 nanoparticles was significantly reduced. This is the first example of cationic SHP-phospholipid nanoparticles for inhibition of brain cholinesterases realized by the use of intranasal administration. This route has promising potential for the treatment of AD