Inverse scattering transform for the Toda hierarchy with steplike finite-gap backgrounds

We provide a rigorous treatment of the inverse scattering transform for the entire Toda hierarchy for solutions which are asymptotically close to (in general) different finite-gap solutions as $n\to\pm\infty$.Comment: 10 page

From Coulomb excitation cross sections to non-resonant astrophysical rates in three-body systems: 17^{17}Ne case

Coulomb and nuclear dissociation of $^{17}$Ne on light and heavy targets are studied theoretically. The dipole E1 strength function is determined in a broad energy range including energies of astrophysical interest. Dependence of the strength function on different parameters of the $^{17}$Ne ground state structure and continuum dynamics is analyzed in a three-body model. The discovered dependence plays an important role for studies of the strength functions for the three-body E1 dissociation and radiative capture. The constraints on the $[s^2]/[d^2]$ configuration mixing in $^{17}$Ne and on $p$-wave interaction in the $^{15}$O+$p$ channel are imposed based on experimental data for $^{17}$Ne Coulomb dissociation on heavy target.Comment: 12 pages, 13 figure

PROTECTIVE PROPERTIES OF THE VACCINE STRAIN 55-VNIIVVIM AND ACAPSULAR STRAIN BACILLUS ANTHRACIS 363/11

Objective of the work was to determine protective potential and safety for animals of the naturally attenuated B. anthracis 363/11 monoplazmid non-capsular strain to be used as a new candidate vaccine strain for the development and enhancement of specific prophylaxis of anthrax. Materials and methods. Vaccine strain 55-VNIIVViM that is used for welfare provision as regards anthrax in animals in the territory of Russia was employed for the comparison of protective properties. Identification of LD50, ImD50 and protective efficacy was carried out using standard protocols for modeling the infection on laboratory (white mice, guinea pigs) and targeted (sheep) animals. Results and conclusions. It is established that avirulent for white mice B. anthracis 363/11 strain demonstrates higher protective and immunogenic activity than 55-VNIIVViM strain. It does not reverse to the virulent variant after passaging on the nutrient media and in the organism of susceptible animals. Thus it allows for considering B. anthracis 363/11 strain as a promising candidate vaccine strain, the utilization of which will improve epizootic situation on anthrax in the Russian Federation

Long-Time Asymptotics of Perturbed Finite-Gap Korteweg-de Vries Solutions

We apply the method of nonlinear steepest descent to compute the long-time asymptotics of solutions of the Korteweg--de Vries equation which are decaying perturbations of a quasi-periodic finite-gap background solution. We compute a nonlinear dispersion relation and show that the $x/t$ plane splits into $g+1$ soliton regions which are interlaced by $g+1$ oscillatory regions, where $g+1$ is the number of spectral gaps. In the soliton regions the solution is asymptotically given by a number of solitons travelling on top of finite-gap solutions which are in the same isospectral class as the background solution. In the oscillatory region the solution can be described by a modulated finite-gap solution plus a decaying dispersive tail. The modulation is given by phase transition on the isospectral torus and is, together with the dispersive tail, explicitly characterized in terms of Abelian integrals on the underlying hyperelliptic curve.Comment: 45 pages. arXiv admin note: substantial text overlap with arXiv:0705.034

Three-body correlations in direct reactions: Example of 6^{6}Be populated in (p,n)(p,n) reaction

The $^{6}$Be continuum states were populated in the charge-exchange reaction $^1$H($^{6}$Li,$^{6}$Be)$n$ collecting very high statistics data ($\sim 5 \times 10^6$ events) on the three-body $\alpha$+$p$+$p$ correlations. The $^{6}$Be excitation energy region below $\sim 3$ MeV is considered, where the data are dominated by contributions from the $0^+$ and $2^+$ states. It is demonstrated how the high-statistics few-body correlation data can be used to extract detailed information on the reaction mechanism. Such a derivation is based on the fact that highly spin-aligned states are typically populated in the direct reactions.Comment: submitted to Physical Review

Complex assessment of narrow-leaved lupine (<i>Lupinus angustifolius</i> L.) accessions from the VIR collection in Belarus

Fifty narrow-leaved lupine accessions of various origin from the VIR collection were studied in Minsk District, Republic of Belarus, and described by a set of morphobiological, biochemical and molecular-genetic characters. According to the results of field and laboratory studies, 10 promising accessions were selected. They are recommended for use in regional breeding programs and included in the working collection of the Belarusian State University

10He low-lying states structure uncovered by correlations

The 0+ ground state of the 10He nucleus produced in the 3H(8He,p)10He reaction was found at about $2.1\pm0.2$ MeV (\Gamma ~ 2 MeV) above the three-body 8He+n+n breakup threshold. Angular correlations observed for 10He decay products show prominent interference patterns allowing to draw conclusions about the structure of low-energy excited states. We interpret the observed correlations as a coherent superposition of the broad 1- state having a maximum at energy 4-6 MeV and the 2+ state above 6 MeV, setting both on top of the 0+ state "tail". This anomalous level ordering indicates that the breakdown of the N=8 shell known in 12Be thus extends also to the 10He system.Comment: 5 pages, 5 figure

Peculiarities of Adverse Events Manifested by Injury of Skin and Skin Derivatives and Associated with Beta-blockers Use

More than 50 years after Propranolol was introduced to the pharmaceutical market as a drug that can lower the heart rate, beta-blockers (BAB) are still widely used in the pharmacotherapy of cardiovascular diseases. However, the use of BAB has a number of limitations, first of all, due to adverse drug events (AE) that develop during their use. The purpose of our review was to study the features of the BAB AE manifested by injuries of the skin and its appendages. The clinical manifestations of them are the development or exacerbation of psoriasis, lichen planus, contact dermatitis, acrocyanosis, Raynaud's disease, alopecia, hyperhidrosis, vitiligo, anaphylaxis, and allergic skin reactions. True medicinal psoriasis occurs in patients taking BAB with no family or previous history and most often mimics erythrodermic psoriasis and palmar-plantar pustular psoriasis. Systemic use of BAB can also be accompanied by exacerbation of vitiligo. In patients with segmental vitiligo, the results of Doppler flowmetry and iontophoresis showed increased blood flow in vitiligo foci compared with normal skin. The development of anaphylactic reactions against the background of BAB therapy may be due to the modulation of adenylate cyclase, which can affect the release of anaphylactogenic mediators, as well as a decrease in the severity of cardiovascular compensatory changes. The peculiarities of the development of such reactions may be the resistance of patients to traditional treatment, which is due to the development of paradoxical reflex vagotonic effects when using adrenaline. Some of the mentioned AE may pose a potential threat to the life and health of the patient and therefore require additional discussion

Genotyping of tick-borne encephalitis and Kemerovo viruses in taiga ticks collected in the Komi Republic

Over the last years, an increasing rate of ixodes tick bites has been registered in the northern regions of the European Russia. In addition, the number of subjects request medical assistance due to tick bites has been dramatically increased in the Komi Republic. In addition, incidence of tick-borne encephalitis was also increased particularly starting since 2009. However, highly limited data on pathogen genetic diversity related to viral tick-borne infections in this region are currently available. Taiga ticks (Ixodespersulcatus) collected from the Komi Republic southern and central part vegetation were examined to identify and genotype tick-borne viruses. Individual ticks were used to identify by RT-PCR viral RNA coupled to tick-borne encephalitis and Kemerovo viruses. Viral genome fragment sequencing allowed to unambiguously identify these viruses. It was found that viral RNA tick-borne encephalitis was detected in 6.8±1.2% individual ticks. Moreover, tick-linked isolate genotyping based on analyzing E protein gene fragment nucleotide sequence derived from tick-borne encephalitis discovered that 35% and 65% isolates belonged to the Far Eastern and Siberian subtype, respectively. In addition, subsequent phylogenetic analysis demonstrated that at least four variants of the Siberian and Far Eastern subtypes of tick-borne encephalitis virus were detected, which were close to the viruses circulating in the Urals and Siberia. In contrast, prevalence of Kemerovo virus in taiga ticks was 0.8±0.2%. Sequencing of Kemerovo virus RNA-dependent RNA polymerase gene fragment showed around 94% homology with the remainder of the Kemerovo virus strains. Phylogenetic analysis of the Kemerovo virus genome fragments demonstrated at least two subtypes circulating in the Komi Republic. Thus, it was suggested that tick-borne encephalitis virus was introduced relatively recently from the Urals and Siberian region into the natural foci of the Komi Republic. Moreover, genetic differences found in Kemerovo virus strains presume for them a longer lasting evolution throughout the natural foci of this region. In addition, a potential role for birds and their ticks in rapid spreading of viral tick-borne infections in the Komi Republic is also discussed. Thus, the data on genetic diversity of the viral agents related to tick-born encephalitis and Kemerovo fever may be useful for improving their diagnostics, prevention and treatment in the Komi Republic

DISSEMINATED CUTANEOUS TUBERCULOSIS

Cutaneous tuberculosis is a clinically and morphologically heterogeneous group of skin diseases directly or indirectly caused by mycobacteria of the tuberculosis complex, occupying the 5th place among all localizations of extra-pulmonary tuberculosis. Manifestations of cutaneous tuberculosis are extremely diverse and depend on the immune status and ways of penetration of mycobacteria into the skin. Skin involvement can occur as a result of exogenous inoculation, contiguous spread from an adjacent focus, or hematogenous spread from other foci. Family cases of disseminated cutaneous tuberculosis are described. A combination of several clinical forms of cutaneous tuberculosis — scrofuloderma, tuberculosis cutis lichenoides (moniliformis scrophulosorum) and lupus — are observed in a 5 year old child with a family history of tuberculosis. The issues of pathogenesis and advanced methods of diagnosis of cutaneous tuberculosis are also discussed