Cavity quantum electro-optics

The quantum dynamics of the coupling between a cavity optical field and a resonator microwave field via the electro-optic effect is studied. This coupling has the same form as the opto-mechanical coupling via radiation pressure, so all previously considered opto-mechanical effects can in principle be observed in electro-optic systems as well. In particular, I point out the possibilities of laser cooling of the microwave mode, entanglement between the optical mode and the microwave mode via electro-optic parametric amplification, and back-action-evading optical measurements of a microwave quadrature.Comment: 6 pages, 3 figures; v2: updated and submitted, v3: extended, accepted by Physical Review

The Microscopic Approach to Nuclear Matter and Neutron Star Matter

We review a variety of theoretical and experimental investigations aimed at improving our knowledge of the nuclear matter equation of state. Of particular interest are nuclear matter extreme states in terms of density and/or isospin asymmetry. The equation of state of matter with unequal concentrations of protons and neutrons has numerous applications. These include heavy-ion collisions, the physics of rare, short-lived nuclei and, on a dramatically different scale, the physics of neutron stars. The "common denominator" among these (seemingly) very different systems is the symmetry energy, which plays a crucial role in both the formation of the neutron skin in neutron-rich nuclei and the radius of a neutron star (a system 18 orders of magnitude larger and 55 orders of magnitude heavier). The details of the density dependence of the symmetry energy are not yet sufficiently constrained. Throughout this article, our emphasis will be on the importance of adopting a microscopic approach to the many-body problem, which we believe to be the one with true predictive power.Comment: 56 pages, review article to appear in the International Journal of Modern Physics

Interdiffusion: A probe of vacancy diffusion in III-V materials

Copyright 1997 by the American Physical Society. Article is available at

Familial Clustering For Weakly-labeled Android Malware Using Hybrid Representation Learning

IEEE Labeling malware or malware clustering is important for identifying new security threats, triaging and building reference datasets. The state-of-the-art Android malware clustering approaches rely heavily on the raw labels from commercial AntiVirus (AV) vendors, which causes misclustering for a substantial number of weakly-labeled malware due to the inconsistent, incomplete and overly generic labels reported by these closed-source AV engines, whose capabilities vary greatly and whose internal mechanisms are opaque (i.e., intermediate detection results are unavailable for clustering). The raw labels are thus often used as the only important source of information for clustering. To address the limitations of the existing approaches, this paper presents ANDRE, a new ANDroid Hybrid REpresentation Learning approach to clustering weakly-labeled Android malware by preserving heterogeneous information from multiple sources (including the results of static code analysis, the metainformation of an app, and the raw-labels of the AV vendors) to jointly learn a hybrid representation for accurate clustering. The learned representation is then fed into our outlieraware clustering to partition the weakly-labeled malware into known and unknown families. The malware whose malicious behaviours are close to those of the existing families on the network, are further classified using a three-layer Deep Neural Network (DNN). The unknown malware are clustered using a standard density-based clustering algorithm. We have evaluated our approach using 5,416 ground-truth malware from Drebin and 9,000 malware from VIRUSSHARE (uploaded between Mar. 2017 and Feb. 2018), consisting of 3324 weakly-labeled malware. The evaluation shows that ANDRE effectively clusters weaklylabeled malware which cannot be clustered by the state-of-theart approaches, while achieving comparable accuracy with those approaches for clustering ground-truth samples

Time-Symmetric Quantum Theory of Smoothing

Smoothing is an estimation technique that takes into account both past and future observations, and can be more accurate than filtering alone. In this Letter, a quantum theory of smoothing is constructed using a time-symmetric formalism, thereby generalizing prior work on classical and quantum filtering, retrodiction, and smoothing. The proposed theory solves the important problem of optimally estimating classical Markov processes coupled to a quantum system under continuous measurements, and is thus expected to find major applications in future quantum sensing systems, such as gravitational wave detectors and atomic magnetometers.Comment: 4 pages, 1 figure, v2: accepted by PR

MEPicides: Potent antimalarial prodrugs targeting isoprenoid biosynthesis

AbstractThe emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the methylerythritol phosphate (MEP) pathway of isoprenoid biosynthesis, including the clinically validated target, deoxyxylulose phosphate reductoisomerase (Dxr). Here we describe RCB-185, a lipophilic prodrug with nanomolar activity against asexual parasites. Growth of P. falciparum treated with RCB-185 was rescued by isoprenoid precursor supplementation, and treatment substantially reduced metabolite levels downstream of the Dxr enzyme. In addition, parasites that produced higher levels of the Dxr substrate were resistant to RCB-185. Notably, environmental isolates resistant to current therapies remained sensitive to RCB-185, the compound effectively treated sexually-committed parasites, and was both safe and efficacious in malaria-infected mice. Collectively, our data demonstrate that RCB-185 potently and selectively inhibits Dxr in P. falciparum, and represents a promising lead compound for further drug development.</jats:p

The observation of long-range three-body Coloumb effects in the decay of 16Ne

The interaction of an $E/A$=57.6-MeV $^{17}$Ne beam with a Be target was used to populate levels in $^{16}$Ne following neutron knockout reactions. The decay of $^{16}$Ne states into the three-body $^{14}$O+$p$+$p$ continuum was observed in the High Resolution Array (HiRA). For the first time for a 2p emitter, correlations between the momenta of the three decay products were measured with sufficient resolution and statistics to allow for an unambiguous demonstration of their dependence on the long-range nature of the Coulomb interaction. Contrary to previous experiments, the intrinsic decay width of the $^{16}$Ne ground state was found to be narrow ($\Gamma<60$~keV), consistent with theoretical estimates.Comment: 6 pages, 5 figure

Optimal waveform estimation for classical and quantum systems via time-symmetric smoothing

Classical and quantum theories of time-symmetric smoothing, which can be used to optimally estimate waveforms in classical and quantum systems, are derived using a discrete-time approach, and the similarities between the two theories are emphasized. Application of the quantum theory to homodyne phase-locked loop design for phase estimation with narrowband squeezed optical beams is studied. The relation between the proposed theory and Aharonov et al.'s weak value theory is also explored.Comment: 13 pages, 5 figures, v2: changed the title to a more descriptive one, corrected a minor mistake in Sec. IV, accepted by Physical Review