О РОЛИ ОТЕЧЕСТВЕННОЙ НАУКИ В РАЗВИТИИ АТОМНОЙ ЭНЕРГЕТИКИ В РЕСПУБЛИКЕ БЕЛАРУСЬ

The history of the development of nuclear science researches in the nuclear center of the Republic of Belarus is described. There were two State programs in Belarus devoted to the problems of the nuclear power. One of them was finished in 2010. Within the program, there have been resolved such tasks as: necessity of the nuclear power engineering, selection of the site for the nuclear power plant, developments of the legislation and regulations to ensure nuclear and radiation safety, as well as project of the strategy for radioactive waste management and spent fuel management. At the second stage for fulfilling the tasks of development and implementation of scientific and technical suggestions, the State program «Scientific support of nuclear power development in the Republic of Belarus for 2009–2010 and for the period till 2020» is carried out. The results of researches within the second program for 2013–2015 years are presented.В статье дается краткий обзор научной деятельности в области атомной энергетики в советский и постсоветский периоды развития Республики Беларусь. Приводятся сведения о производстве и потреблении электроэнергии, которые свидетельствуют о целесообразности развития атомной энергетики в Республике Беларусь. Описываются этапы развития работ в этой области. Первый этап включает обоснование необходимости строительства АЭС, ее мощности, определение места размещения, выбор площадки АЭС, разработку нормативной правовой и нормативной технической базы и проекта стратегии обращения с радиоактивными отходами и отработавшим ядерным топливом в Республике Беларусь. Указанные задачи решались в 2006–2010 гг. в рамках Государственной научно-технической программы «Ядерно-физические технологии для народного хозяйства Беларуси». На втором этапе с целью разработки и внедрения научно-технических предложений об оптимизации технологических процессов, повышающих ядерную, радиационную и экологическую безопасность, физическую защиту, а также эффективность объектов использования атомной энергии, была утверждена Государственная программа «Научное сопровождение развития атомной энергетики в Республике Беларусь на 2009–2010 годы и на период до 2020 года». Поскольку результаты выполнения заданий этой программы за 2009–2012 гг. были опубликованы ранее, в статье приводятся результаты исследований за 2013–2015 гг.

Analysis of the CD1 Antigen Presenting System in Humanized SCID Mice

CD1 molecules are glycoproteins that present lipids and glycolipids for recognition by T cells. CD1-dependent immune activation has been implicated in a wide range of immune responses, however, our understanding of the role of this pathway in human disease remains limited because of species differences between humans and other mammals: whereas humans express five different CD1 gene products (CD1a, CD1b, CD1c, CD1d, and CD1e), muroid rodents express only one CD1 isoform (CD1d). Here we report that immune deficient mice engrafted with human fetal thymus, liver, and CD34+ hematopoietic stem cells develop a functional human CD1 compartment. CD1a, b, c, and d isoforms were highly expressed by human thymocytes, and CD1a+ cells with a dendritic morphology were present in the thymic medulla. CD1+ cells were also detected in spleen, liver, and lungs. APCs from spleen and liver were capable of presenting bacterial glycolipids to human CD1-restricted T cells. ELISpot analyses of splenocytes demonstrated the presence of CD1-reactive IFN-γ producing cells. CD1d tetramer staining directly identified human iNKT cells in spleen and liver samples from engrafted mice, and injection of the glycolipid antigen α-GalCer resulted in rapid elevation of human IFN-γ and IL-4 levels in the blood indicating that the human iNKT cells are biologically active in vivo. Together, these results demonstrate that the human CD1 system is present and functionally competent in this humanized mouse model. Thus, this system provides a new opportunity to study the role of CD1-related immune activation in infections to human-specific pathogens

Raising the NKT cell family

Natural killer T cells (NKT cells) are CD1d-restricted, lipid antigen–reactive, immunoregulatory T lymphocytes that can promote cell-mediated immunity to tumors and infectious organisms, including bacteria and viruses, yet paradoxically they can also suppress the cell-mediated immunity associated with autoimmune disease and allograft rejection. Furthermore, in some diseases, such as atherosclerosis and allergy, NKT cell activity can be deleterious to the host. Although the precise means by which these cells carry out such contrasting functions is unclear, recent studies have highlighted the existence of many functionally distinct NKT cell subsets. Because their frequency and number vary widely between individuals, it is important to understand the mechanisms that regulate the development and maintenance of NKT cells and subsets thereof, which is the subject of this review