3 research outputs found

    Π­Π²ΠΎΠ»ΡŽΡ†ΠΈΡ АрктичСской ΠΏΠΎΠ»ΠΈΡ‚ΠΈΠΊΠΈ БША

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    The article examines the development of the US Arctic policy which is reflected in the US strategic documents. The author examines the evolution of doctrinal purposes from those focusing on environmental issues and regional cooperation to those focusing on logistics, security and military infrastructure. The evolution of the US strategic documents is considered in the context of the activities of such actors as Russia, Canada, China and a number of international organizations in the Arctic region. Contradictions and existing and prospective areas of cooperation are noted. The author shows the immutability of the US key strategic guidelines of the United States aimed at securing the status of an Arctic power for the United States and ensuring the promotion and protection of the US interests in the region.Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ рассматриваСтся Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠ΅ арктичСской ΠΏΠΎΠ»ΠΈΡ‚ΠΈΠΊΠΈ БША, нашСдшСС ΠΎΡ‚Ρ€Π°ΠΆΠ΅Π½ΠΈΠ΅ Π² Π΄ΠΎΠΊΡƒΠΌΠ΅Π½Ρ‚Π°Ρ… стратСгичСского планирования. Автор рассматриваСт ΡΠ²ΠΎΠ»ΡŽΡ†ΠΈΡŽ Π΄ΠΎΠΊΡ‚Ρ€ΠΈΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… установок ΠΎΡ‚ сосрСдоточСнных Π½Π° вопросах экологии ΠΈ ΠΏΠΎΡΡ‚ΡƒΠ»ΠΈΡ€ΡƒΡŽΡ‰ΠΈΡ… Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΠΎΡΡ‚ΡŒ Ρ€Π΅Π³ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ сотрудничСства Π΄ΠΎ Π°ΠΊΡ†Π΅Π½Ρ‚ΠΈΡ€ΡƒΡŽΡ‰ΠΈΡ… вопросы логистики, бСзопасности ΠΈ Π²ΠΎΠ΅Π½Π½ΠΎΠΉ инфраструктуры. Π­Π²ΠΎΠ»ΡŽΡ†ΠΈΡ стратСгичСских установок рассматриваСтся Π² контСкстС Π΄Π΅ΡΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ Π² арктичСском Ρ€Π΅Π³ΠΈΠΎΠ½Π΅ Ρ‚Π°ΠΊΠΈΡ… Π°ΠΊΡ‚ΠΎΡ€ΠΎΠ², ΠΊΠ°ΠΊ Россия, Канада, ΠšΠΈΡ‚Π°ΠΉ ΠΈ ряда ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½Ρ‹Ρ… ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΉ. ΠžΡ‚ΠΌΠ΅Ρ‡Π°ΡŽΡ‚ΡΡ противорСчия, ΡΡƒΡ‰Π΅ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΠ΅ ΠΈ пСрспСктивныС направлСния сотрудничСства. Автор ΠΏΠΎΠΊΠ°Π·Ρ‹Π²Π°Π΅Ρ‚ Π½Π΅ΠΈΠ·ΠΌΠ΅Π½Π½ΠΎΡΡ‚ΡŒ ΠΊΠ»ΡŽΡ‡Π΅Π²Ρ‹Ρ… стратСгичСских установок БША, Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½Π½Ρ‹Ρ… Π½Π° Π·Π°ΠΊΡ€Π΅ΠΏΠ»Π΅Π½ΠΈΠ΅ Π·Π° БША статуса арктичСской Π΄Π΅Ρ€ΠΆΠ°Π²Ρ‹ ΠΈ обСспСчСниС продвиТСния ΠΈ Π·Π°Ρ‰ΠΈΡ‚Ρ‹ интСрСсов государства Π² Ρ€Π΅Π³ΠΈΠΎΠ½Π΅

    ЀотодинамичСская тСрапия Π² Π»Π΅Ρ‡Π΅Π½ΠΈΠΈ ΠΈΠ½Ρ‚Ρ€Π°ΡΠΏΠΈΡ‚Π΅Π»ΠΈΠ°Π»ΡŒΠ½Ρ‹Ρ… Π½Π΅ΠΎΠΏΠ»Π°Π·ΠΈΠΉ шСйки ΠΌΠ°Ρ‚ΠΊΠΈ, Π²ΡƒΠ»ΡŒΠ²Ρ‹ ΠΈ Π²Π»Π°Π³Π°Π»ΠΈΡ‰Π°

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    In the present review the authors analyzed the effectiveness of treatment of intraepithelial neoplasia I-II-III of the cervix (CIN), vulva (VIN) and vagina (VaIN) using photodynamic therapy (PDT). PDT is a method based on exposure to light after preliminary introduction of a photosensitizer into the body with the formation of singlet oxygen, which has a cytotoxic effect. The results of research on the use of PDT with various photosensitizers in the complex of therapeutic measures in patients with CIN, VIN, VaIN are presented. These data on the effectiveness and safety of PDT, ease of use allow this medical technology to be attributed to one of the most promising areas in the treatment of pathological intraepithelial changes of the cervix, vulva and vagina. The presented information allows focusing the attention on the PDT method and informing doctors and researchers about the broad prospects for applying this treatment method in clinical practice.Π’ ΠΎΠ±Π·ΠΎΡ€Π΅ Π»ΠΈΡ‚Π΅Ρ€Π°Ρ‚ΡƒΡ€Ρ‹ прСдставлСн Π°Π½Π°Π»ΠΈΠ· эффСктивности лСчСния ΠΈΠ½Ρ‚Ρ€Π°ΡΠΏΠΈΡ‚Π΅Π»ΠΈΠ°Π»ΡŒΠ½ΠΎΠΉ Π½Π΅ΠΎΠΏΠ»Π°Π·ΠΈΠΈ I-II-III стСпСни шСйки ΠΌΠ°Ρ‚ΠΊΠΈ (CIN), Π²ΡƒΠ»ΡŒΠ²Ρ‹ (VIN) ΠΈ Π²Π»Π°Π³Π°Π»ΠΈΡ‰Π° (VaIN) с использованиСм фотодинамичСской Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ (Π€Π”Π’). Π€Π”Π’ – ΠΌΠ΅Ρ‚ΠΎΠ΄, основанный Π½Π° воздСйствии свСтом послС ΠΏΡ€Π΅Π΄Π²Π°Ρ€ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ ввСдСния Π² ΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΌ фотосСнсибилизатора с ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ синглСтного кислорода, ΠΎΠΊΠ°Π·Ρ‹Π²Π°ΡŽΡ‰Π΅Π³ΠΎ цитотоксичСский эффСкт. ΠŸΡ€Π΅Π΄ΡΡ‚Π°Π²Π»Π΅Π½Ρ‹ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ исслСдований ΠΏΠΎ использованию Π€Π”Π’ с Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹ΠΌΠΈ фотосСнсибилизаторами Π² комплСксС Π»Π΅Ρ‡Π΅Π±Π½Ρ‹Ρ… мСроприятий Ρƒ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… с CIN, VIN, VaIN. ΠŸΡ€ΠΈΠ²Π΅Π΄Π΅Π½Π½Ρ‹Π΅ Π΄Π°Π½Π½Ρ‹Π΅ ΠΎΠ± эффСктивности ΠΈ бСзопасности Π€Π”Π’, простота примСнСния ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡŽΡ‚ Π΄Π°Π½Π½ΡƒΡŽ ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½ΡΠΊΡƒΡŽ Ρ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΡŽ отнСсти ΠΊ числу Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ пСрспСктивных Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½ΠΈΠΈΜ† Π² Π»Π΅Ρ‡Π΅Π½ΠΈΠΈ Ρ€Π°Π·Π»ΠΈΡ‡Π½ΠΎΠΉ стСпСни выраТСнности ΠΈΠ½Ρ‚Ρ€Π°ΡΠΏΠΈΡ‚Π΅Π»ΠΈΠ°Π»ΡŒΠ½Ρ‹Ρ… ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ шСйки ΠΌΠ°Ρ‚ΠΊΠΈ, Π²ΡƒΠ»ΡŒΠ²Ρ‹ ΠΈ Π²Π»Π°Π³Π°Π»ΠΈΡ‰Π°. ΠŸΡ€Π΅Π΄ΡΡ‚Π°Π²Π»Π΅Π½Π½Π°Ρ информация ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ‚ Π°ΠΊΡ†Π΅Π½Ρ‚ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ Π½Π° Π€Π”Π’ ΠΈ ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ Π²Ρ€Π°Ρ‡Π΅ΠΈΜ† ΠΈ Π½Π°ΡƒΡ‡Π½Ρ‹Ρ… сотрудников ΠΎ ΡˆΠΈΡ€ΠΎΠΊΠΈΡ… пСрспСктивах примСнСния Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΌΠ΅Ρ‚ΠΎΠ΄Π° Π² клиничСской ΠΏΡ€Π°ΠΊΡ‚ΠΈΠΊΠ΅

    Vaccination against HPV: Theoretical Aspects and Practical Results of Cervical Cancer Prevention

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    Relevance. Cervical cancer (CC) continues to be the focus of attention of oncologists all over the world due to the fact that the incidence of it over the past decades has not tended to decrease. The steady increase in morbidity, high mortality rates, and the tendency to Β«rejuvenateΒ» the disease, the relatively low detection rate of the early stages of the disease due to poor results of cytological screening predetermine the search for new scientifically based approaches to solving cervical cancer problems. A promising direction for the prevention of squamous cell carcinoma and adenocarcinoma associated with human papillomavirus (HPV) is prophylactic vaccination against HPV, the need for which is due to the role of HPV infection in carcinogenesis processes.The aim of this article is to summarize the currently available data on advances in the prevention of precancerous lesions and cervical cancer, primarily through vaccination against HPV infection.Conclusions. The creation of vaccines for the prevention of oncogenic HPV types is a significant achievement in the biomedical research area. The successful development of a group of vaccines, which can confidently be called the vaccines of the 21st century, gives us hope that modern medicine has the potential to reduce population cancer risk and reduce the likelihood of early onset of cervical cancer. Demonstration of the efficacy and feasibility of routine HPV vaccination programs in a number of countries demonstrates encouraging progress in solving cervical cancer problems. Vaccination against HPV will not only ensure epidemiological well-being, but also lead to a decrease in morbidity and mortality from such a terrible complication of human papillomavirus infection – cervical cancer
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