Mission At and From the Margins Patterns, Protagonists and Perspectives

It is our hope that these chapters, though fragmentary in nature, will provide glimpses of how the ‘margins’ can both inform and re-form missiological thought as we build further upon what has happened since Edinburgh 1910. These fragments are offered with the hope that they will not only feed and nourish but also provoke hunger for working towards God’s kingdom of justice and righteousness.https://scholar.csl.edu/edinburghcentenary/1016/thumbnail.jp

SWKB Quantization Rules for Bound States in Quantum Wells

In a recent paper by Gomes and Adhikari (J.Phys B30 5987(1997)) a matrix formulation of the Bohr-Sommerfield quantization rule has been applied to the study of bound states in one dimension quantum wells. Here we study these potentials in the frame work of supersymmetric WKB (SWKB) quantization approximation and find that SWKB quantization rule is superior to the modified Bohr-Sommerfield or WKB rules as it exactly reproduces the eigenenergies.Comment: 8 page

Proton coupled electron transfer reaction of phenols with excited state ruthenium(II) - polypyridyl complexes

The reaction of phenols with the excited state, *[Ru(bpy)3]2+ (E0 = 0.76V) and *[Ru(H2dcbpy)3]2+, (dcbpy = 4,4'-dicarboxy-2,2'-bipyridine) (E0 = 1.55 V vs. SCE) complexes in CH3CN has been studied by luminescence quenching technique and the quenching is dynamic. The formation of phenoxyl radical as a transient is confirmed by its characteristic absorption at 400 nm. The kq value is highly sensitive to the change of pH of the medium and ΔG0 of the reaction. Based on the treatment of kq data in terms of energetics of the reaction and pH of the medium, proton coupled electron transfer (PCET) mechanism has been proposed for the reaction

Apathy and Its Response to Antipsychotic Review and Nonpharmacological Interventions in People With Dementia Living in Nursing Homes: WHELD, a Factorial Cluster Randomized Controlled Trial

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this recordObjectives Apathy is common, impactful, and difficult to manage in people with dementia. We evaluated the efficacy of nonpharmacological interventions, exercise, and social interaction, in combination with antipsychotic review, to reduce apathy in people with dementia living in nursing homes in a cluster randomized controlled trial (RCT). Methods Well-being and health for people with dementia (WHELD) program included a 2 × 2 × 2 factorial cluster RCT involving people with dementia living in 16 nursing homes in the United Kingdom. All homes received training in person-centered care, and were randomized to receive antipsychotic review, social interaction, and exercise, either alone or in combinations. Apathy was one of the secondary outcomes of the WHELD trial, and it was measured by the Neuropsychiatric Inventory–nursing home version at baseline and 9 months (n = 273). We used multilevel mixed effects linear regression models to assess the impact of the interventions on apathy. Results Prevalence of apathy was 44.0% (n = 120; 95% confidence interval [CI] 38.1%–49.9%) at baseline. Severity of apathy had significant positive correlations with dementia severity, neuropsychiatric symptoms, depressive symptoms, agitation, and the needs of the people with dementia (P < .001). Antipsychotic review reduced antipsychotic use, but it significantly increased apathy (β = 5.37; SE = 0.91; P < .001). However, antipsychotic review in combination with either social interaction (β = −5.84; SE = 1.15; P < .001) or exercise (β = −7.54; SE = 0.93; P < .001) significantly reduced apathy. Conclusions Antipsychotic review can play a significant role in improving apathy in people with dementia living in nursing homes, when combined with psychosocial interventions such as social interaction and exercise. Guidance must be adapted to reflect this subtlety in care.National Institute for Health Research (NIHR

Effects of sand and gating architecture on the performance of foot valve lever casting components used in pump industries

Funding Information: The authors thank Kalasalingam Academy of Research and Education, Krishnankoil for providing the facilities for various tests and characterizations. The King Saud University authors extend their appreciation to the Deanship of Scientific Research at King Saud University for funding the work through the research group project no. RG-148. This Research was funded by King Mongkut's University of Technology North Bangkok has received funding support from the National Science, Research and Innovation Fund (NSRF) (Grant No. KMUTNB-MHESI-64-16.1). Publisher Copyright: © 2021 The Author(s)This work addresses manufacture, testing and simulation of foot valve lever (FVL) for monoblock pump industry, using a cost-effective casting design process. The impact of different types of sands, such as air-set, dry and sodium silicate as well as gating designs, namely H-, U- and O-type, were studied with respect to surface roughness and porosity. The mold pattern was produced using additive manufacturing (AM) technology. Both experimental and numerical investigations were performed on the temperature distribution of molten metal at random locations for the different gating configurations or designs, considering mold filling and solidification. It was evident from the experimental investigation that contribution of air-set sand and O-type gating architecture showed limited consistency effects. Importantly, gating architecture was the most influential parameter to determine all specified quality outcomes, independent of sand mold. An order of O < H < U-type was obtained from the gating designs for minimal surface roughness and percentage of porosity. Furthermore, the microstructure analysis depicted only an irregular defect with minimum quantity at both surface and cross-section of O-type at two different locations. Optimum pouring temperatures of 740, 750 and 790 °C were obtained for mold filling of all 24 components of H-, O- and U-type of gating designs, respectively. The varying solidification temperature was observed from real time thermocouple reading, which was in close agreement with the numerical simulation. Evidently, O-type of gating design exhibited best performance for large-scale development of the FVL in terms of surface roughness, porosity and cooling effects.Peer reviewe

Effect of biochar on the growth of Ricinus communis grown on copper smelter waste: A pot scale study

The authors acknowledge the work support by RFBR, Russia (Project № 19-516-45006) and DST, India (INT/RUS/RFBR/363) and the Ural Federal University Competitiveness Enhancement Program, Act 211 Government of the Russian Federation (сontract № 02.A03.21.0006)

Peptide hydrogen-bonded organic frameworks

This research was supported by the DST Inspire Faculty Fellowship (No. DST/INSPIRE/04/2020/002499) from the Department of Science and Technology, New Delhi. R. M. is also thankful to the National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, for providing the research facilities. T. V. thanks Tel Aviv University for the postdoctoral fellowship. E. G. thanks European Research Council PoC project PepZoPower (101101071). A. I. N. thanks the American Chemical Society Petroleum Research Fund (62285-DNI). S. B. thanks SERB, Govt. of India, for the Ramanujan Fellowship (Ref. no. RJF/2022/000042), and Ashoka University, Sonipat, Haryana, for the infrastructure. S. N. acknowledges Vellore Institute of Technology Chennai for the funding and infrastructure.Hydrogen-bonded porous frameworks (HPFs) are versatile porous crystalline frameworks with diverse applications. However, designing chiral assemblies or biocompatible materials poses significant challenges. Peptide-based hydrogen-bonded porous frameworks (P-HPFs) are an exciting alternative to conventional HPFs due to their intrinsic chirality, tunability, biocompatibility, and structural diversity. Flexible, ultra-short peptide-based P-HPFs (composed of 3 or fewer amino acids) exhibit adaptable porous topologies that can accommodate a variety of guest molecules and capture hazardous greenhouse gases. Longer, folded peptides present challenges and opportunities in designing P-HPFs. This review highlights recent developments in P-HPFs using ultra-short peptides, folded peptides, and foldamers, showcasing their utility for gas storage, chiral recognition, chiral separation, and medical applications. It also addresses design challenges and future directions in the field.Peer reviewe

Analysis of inhibition concentration (ic) of cadmium, copper, lead and zinc in mugil cephalus, perna viridis and penaeus monodon under short term chronic toxicity tests

ABSTRACT The present study was conducted to estimate the inhibition concentration (IC 25 ) causing 25 per cent reduction in growth of Mugil cephalus, Perna viridis and Penaeus monodon induced by cadmium, copper, lead and zinc in short term chronic toxicity test (30 days). The IC 25 for M.cephalus was high in all the metal exposure except cadmium. P.monodon had the lowest IC 25 of copper and cadmium and P.viridis showed lowest IC 25 for lead and zinc. Low concentrations of heavy metals; cadmium, copper, lead and zinc are good enough to bring 25 percent inhibition in growth for P.monodon and P.viridis. In the other hand, M.cephalus required higher concentrations to bring a considerable effect in growth. Signifying that mullet juveniles are tolerant to heavy metals when compared to P.monodon and P.viridis. Essential and non-essential metals can produce toxic effects in fish by disturbing their growth and mortality. The difference caused may be due to various ecological and physiological events of the toxicological experiments and duration of the study

Epidemiology of Pain in People With Dementia Living in Care Homes: Longitudinal Course, Prevalence, and Treatment Implications

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this recordIntroduction Knowledge regarding the longitudinal course, impact, or treatment implications of pain in people with dementia living in care homes is very limited. Methods We investigated the people with dementia living in 67 care homes in London and Buckinghamshire, United Kingdom. Pain, dementia severity, neuropsychiatric symptoms, depression, agitation, and quality-of-life were measured using appropriate instruments at baseline (N = 967) and after 9 months (n = 629). Results Baseline prevalence of pain was 35.3% (95% CI 32.3–38.3). Pain severity was significantly correlated with dementia severity, neuropsychiatric symptoms, depression, agitation, and quality of life at both time points. Regular treatment with analgesics significantly reduced pain severity. Pain was significantly associated with more antipsychotic prescriptions. Pain was significantly associated (OR 1.48; 95% CI 1.18–1.85) with all-cause mortality during follow-up. Conclusions Pain is an important determinant of neuropsychiatric symptoms, mortality, quality-of-life, and antipsychotic prescriptions. Improved identification, monitoring, and treatment of pain are urgent priorities to improve the health and quality-of-life for people with dementia.National Institute for Health Research (NIHR