Creation of Digital Ecosystem in the Context of Region Sustainable Industrialization

This paper presents features, approaches and institutional conditions, implications of digital technologies focused on the sustainable industrial development of the regional economy. The objective of the study is to analyse possibilities of the practical implementation of measures on digital ecosystem creation of separate region, Kostanay Region of the Republic of Kazakhstan, the industrial region of country having a certain innovation potential. This paper uses scientific methods of enquiry, statistical data and mathematical modelling in economics. In the result of study digital technology development priorities at the national level were established and the digitalization impact on the regional development was emphasised. The empirical analysis basis served the results of studies conducted within R&D Developing the Government Regulation Policy on Accelerated Clustering of Industrial Regions conducted under the grant financing of Ministry of Education and Science of the Republic of Kazakhstan. © The Authors, published by EDP Sciences, 2020.The empirical analysis basis served the results of studies conducted within R&D “Developing the Government Regulation Policy on Accelerated Clustering of Industrial Regions” conducted under the grant financing of Ministry of Education and Science of the epublic of Kazakhstan

Определение сакситоксина в воде озера Байкал

Выполнено определение сакситоксина в пробах поверхностной воды, отобранной летом 2018 года в период массового цветения цианобактерий в прибрежной зоне заливов Ая, Тутай (западное побережье Байкала), Мухор (пролив Малое Море), Посольский сор и около села Турка (восточное побережье Байкала). Для определения сакситоксина использована методика определения, основанная на химической модификации сакситоксина 2,4-динитрофенилгидразином с последующей идентификацией гидразона сакситоксина методом жидкостной хроматографии с масс-спектрометрическим детектированием. Для проб с ожидаемой низкой концентрацией сакситоксина предложен усовершенствованный вариант методики. Показано, что содержание сакситоксина в воде во всех исследованных пробах ниже рекомендованной для питьевой воды (< 3 мкг/л)

Neoglycolipids Micelle-like Structures as a Basis for Drug Delivery Systems

Targeted drug delivery is one of the most promising tasks of nanomedicine, as this is a real way to increase the effectiveness of therapeutic effects against many diseases. In this regard, the development of new inexpensive highly effective stimulating and non-immunogenic drug delivery systems (DDS) is of great importance. In this work new molecular candidates were proposed and studied for the creation of such systems based on the use of new compounds, neoglycolipids. It is shown that these compounds are capable of self-association in aqueous solutions and can serve as potential carriers of drug compounds with targeted delivery determined by their terminal groups (in particular, glycans). The processes of their associates formation and features of their structure are investigated. The results show that these selforganizing nanoscale systems can be used as a basis for developing new drug delivery systems. Keywords: neoglycolipids, micelle-like structures, small-angle X-ray scattering, molecular dynamics simulatio