20 research outputs found
In-silico Modulation of the Irinotecan Release from a Functionalized MCM-41 Support
Get PDFThe release rate of a drug molecule from a porous support depends on a large number of factors, including support characteristics, surface functionalization (procedure and linker type), drug features, biological receptor fluid characteristics, and release conditions.
Model-based (in-silico) modulation of the release rate through influential parameters can help in designing an optimized delivery system for a specific drug action. To prevent biased predictions, a dynamic mechanism-based model was adopted, by including
kinetic terms related to surface adsorption-desorption, diffusion in pores, and external diffusion of the drug to the body fluid. Exemplification is made for the case of a functionalized silica MCM-41 support with a tunable pore size distribution and functionalization possibilities with hydrophobic (triethoxyvinylsilane, VTES) or hydrophilic (3-aminopropyl triethoxysilane, APTES) linkers. Variation of several structural parameters, referring to the average pore size, initial drug load, and linker proportion on a bi-functionalized support, pointed out the strong nonlinear relationships between the process
variables and the release rate
In-silico Modulation of the Irinotecan Release from a Functionalized MCM-41 Support
Get PDFThe release rate of a drug molecule from a porous support depends on a large number of factors, including support characteristics, surface functionalization (procedure and linker type), drug features, biological receptor fluid characteristics, and release conditions.
Model-based (in-silico) modulation of the release rate through influential parameters can help in designing an optimized delivery system for a specific drug action. To prevent biased predictions, a dynamic mechanism-based model was adopted, by including
kinetic terms related to surface adsorption-desorption, diffusion in pores, and external diffusion of the drug to the body fluid. Exemplification is made for the case of a functionalized silica MCM-41 support with a tunable pore size distribution and functionalization possibilities with hydrophobic (triethoxyvinylsilane, VTES) or hydrophilic (3-aminopropyl triethoxysilane, APTES) linkers. Variation of several structural parameters, referring to the average pore size, initial drug load, and linker proportion on a bi-functionalized support, pointed out the strong nonlinear relationships between the process
variables and the release rate
Variability in Trust in the Heart Transplant Team Internationally and Its Relation to Patient and Center Level Factors in Heart Transplant Centers: The International Cross-Sectional BRIGHT Study
No full textBayesian Correction for Exposure Misclassification and Evolution of Evidence in Two Studies of the Association Between Maternal Occupational Exposure to Asthmagens and Risk of Autism Spectrum Disorder
No full textPreliminary Development and Evaluation of an Algorithm to Identify Breast Cancer Chemotherapy Toxicities Using Electronic Medical Records and Administrative Data
No full textStability improvement and control of grid-connected photovoltaic system during faults using supercapacitor
No full textInterest in Genetic Testing for Modest Changes in Breast Cancer Risk: Implications for SNP Testing
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High-Yield Syntheses of Tetra-O-benzyl-α-D-glucopyranosyl bromide and Tetra-O-pivaloyl-α-D-glucopyranosyl bromide and their Advantage in the Koenigs-Knorr Reaction
No full textStudy design and baseline characteristics of a combined educational and environmental intervention trial to lower sodium intake in Swiss employees
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