9 research outputs found
Depressive Disorder as Possible Risk Factor of Osteoporosis
Hipothalamo-pituitary-adrenal (HPA) axis is a very complicated control system
playing an important role in stress reaction, where glucocorticoids suppress the autonomic
(vegetative), endocrine, immunologic and psychic responses to stressful stimuli.
We described the marked clinical, physiological, and biochemical connection between osteoporosis
and major depressive disorder (MDD). Both conditions are associated with a
hyperactive HPA axis and LC/NE system, and hence with increased CRH, cortisol, and
catecholamine secretion. There are numerous states or diseases associated with osteoporosis
and we were looking for a hypercorticism value as a one of these. Some recent studies
demonstrated that earlier history of MDD was associated with marked osteoporosis.
In MDD there are two well-documented biochemical abnormalities: hypercortisolism
and its resistance to dexamethasone suppression. The present study included 31 MDD
patients (19 males and 12 females, mean age 37 1.3, age range 29ā41 years), and 17
healthy male volunteers (mean age 39 1.6, age range 34ā45 years). In each of our patients
24-hour urinary free cortisol, serum cortisol level at 8 a.m. and 5 p.m., cortisol in
dexamethasone suppression test and bone mineral density were measured. We have,
therefore, analyzed a group of young men and women with normal menstrual cycles,
who were without signs of osteoporosis in the beginning, and who received anti-depressive
therapy for many years. Analysis showed that increased levels of cortisol and the occurrence
of osteoporosis, that developed as the result of elevated cortisol level. For our
workshop we used nonparametric rang-correlation with Spearmanās ro = ā0.805, with
statistic significant at the 0.01 level (2-tailed). Patients under long-term history of depression
could develop a very stronger type of osteoporosis i.e. it is before known that the
patients with untreated Cushing syndrome developed hard osteoporosis
Increased expression of endothelial lipase in symptomatic and unstable carotid plaques
The aim of this study was to evaluate endothelial lipase (EL) protein expression in advanced human carotid artery plaques (HCAP) with regard to plaque (in)stability and the incidence of symptoms. HCAP were collected from 66 patients undergoing carotid endarterectomy (CEA). The degree of plaque (in)stability was estimated by ultrasound and histology. In HCAP sections, EL expression was determined by immunostaining and the intensity was assessed on a semi-quantitative scale (low: <25%, high: >25% positive cells). Monocytes and macrophages in adjacent HCAP sections were stained with a CD163 specific antibody. High EL staining was more prevalent in histologically unstable plaques (in 33.3% of fibrous plaques, 50% of ulcerated non-complicated plaques and 79.2% of ulcerated complicated plaques; Ļ2 test, pĀ =Ā 0.004) and in the symptomatic group (70.8 vs. 42.9% in the asymptomatic group; Ļ2 test, pĀ =Ā 0.028). The majority of EL immunostaining was found in those HCAP regions exhibiting a strong CD163 immunostaining. EL in HCAP might be a marker and/or promoter of plaque instability and HCAP-related symptomatology
Depressive Disorder as Possible Risk Factor of Osteoporosis
Hipothalamo-pituitary-adrenal (HPA) axis is a very complicated control system playing an important role in stress reaction, where glucocorticoids suppress the autonomic (vegetative), endocrine, immunologic and psychic responses to stressful stimuli.
We described the marked clinical, physiological, and biochemical connection between osteoporosis and major depressive disorder (MDD). Both conditions are associated with a hyperactive HPA axis and LC/NE system, and hence with increased CRH, cortisol, and catecholamine secretion. There are numerous states or diseases associated with osteoporosis and we were looking for a hypercorticism value as a one of these. Some recent studies demonstrated that earlier history of MDD was associated with marked osteoporosis. In MDD there are two well-documented biochemical abnormalities: hypercortisolism and its resistance to dexamethasone suppression. The present study included 31 MDD patients (19 males and 12 females, mean age 37 1.3, age range 29ā41 years), and 17 healthy male volunteers (mean age 39 1.6, age range 34ā45 years). In each of our patients
24-hour urinary free cortisol, serum cortisol level at 8 a.m. and 5 p.m., cortisol in dexamethasone suppression test and bone mineral density were measured. We have, therefore, analyzed a group of young men and women with normal menstrual cycles,
who were without signs of osteoporosis in the beginning, and who received anti-depressive therapy for many years. Analysis showed that increased levels of cortisol and the occurrence of osteoporosis, that developed as the result of elevated cortisol level. For our workshop we used nonparametric rang-correlation with Spearmanās ro = ā0.805, with statistic significant at the 0.01 level (2-tailed). Patients under long-term history of depression could develop a very stronger type of osteoporosis i.e. it is before known that the patients with untreated Cushing syndrome developed hard osteoporosis