Experiencing Financial Aid at a Historically White Institution: A Critical Race Analysis

While scholars have looked at the intersection of financial aid and various identities, little work has examined how, if at all, race and racism are imbued into financial aid in higher education using qualitative inquiry. This paper begins that work by using a Critical Race Theory lens to analyze how, in the seemingly colorblind structure and process of financial aid, race matters. Using interview data collected from 35 Black juniors and seniors at a selective, historically White institution (HWI), the authors examine how race has informed students’ perceptions of themselves, their families, and their futures through their experiences with financial aid. The authors found that financial aid took the form of 1) a racial stereotype and microaggression, 2) added labor in searching for scholarships, and 3) a factor in reinforcing the racial wealth divide. More than a resource to facilitate college access and persistence, these scholars argue that financial aid is racialized, uniquely shaping the campus experience of Black collegians

Student-Centered Pedagogy: Using Moses’ Five-Step Approach as a Scaffolding Framework to Teach Diverse Learners

In this article, two teacher educators and three preservice teachers reflect on the critical role Moses’ Five-Step Approach (Moses & Cobb, 2001) played as a scaffolding pedagogical framework in preservice teacher and faculty learning. Using Moses’ approach to frame their presentations, preservice teachers work in their groups to teach abstract Educational Psychology concepts to actively engage classmates from diverse backgrounds. During this process, the presenters co-construct knowledge with their peers and instructor, applying the framework by putting common activities and everyday language first before teaching abstract concepts and academic language. The authors, including a preservice teacher who also teaches a university biology course, explicate the process of their experience, beginning with conceptualizing a theme, generating engaging activities that represent the concepts and tap into multimodalities of learning, and breaking down key vocabulary to connect to students’ prior knowledge in a socially constructed environment. The authors reflect on the power of this student-centered framework as well as its challenges. Ultimately, Moses’ approach serves as a liberating framework, allowing diverse learners a common entry point to experience and comprehend complex concepts and vocabulary. This pedagogical framework fosters a rich student-centered environment where students become active agents of their own learning

Pathfinder cells provide a novel therapeutic intervention for acute kidney injury

Pathfinder cells (PCs) are a novel class of adult-derived cells that facilitate functional repair of host tissue. We used rat PCs to demonstrate that they enable the functional mitigation of ischemia reperfusion (I/R) injury in a mouse model of renal damage. Female C57BL/6 mice were subjected to 30 min of renal ischemia and treated with intravenous (i.v.) injection of saline (control) or male rat pancreas-derived PCs in blinded experimentation. Kidney function was assessed 14 days after treatment by measuring serum creatinine (SC) levels. Kidney tissue was assessed by immunohistochemistry (IHC) for markers of cellular damage, proliferation, and senescence (TUNEL, Ki67, p16ink4a, p21). Fluorescence in situ hybridization (FISH) was performed to determine the presence of any rat (i.e., pathfinder) cells in the mouse tissue. PC-treated animals demonstrated superior renal function at day 14 post-I/R, in comparison to saline-treated controls, as measured by SC levels (0.13 mg/dL vs. 0.23 mg/dL, p<0.001). PC-treated kidney tissue expressed significantly lower levels of p16ink4a in comparison to the control group (p=0.009). FISH analysis demonstrated that the overwhelming majority of repaired kidney tissue was mouse in origin. Rat PCs were only detected at a frequency of 0.02%. These data confirm that PCs have the ability to mitigate functional damage to kidney tissue following I/R injury. Kidneys of PC-treated animals showed evidence of improved function and reduced expression of damage markers. The PCs appear to act in a paracrine fashion, stimulating the host tissue to recover functionally, rather than by differentiating into renal cells. This study demonstrates that pancreatic-derived PCs from the adult rat can enable functional repair of renal damage in mice. It validates the use of PCs to regenerate damaged tissues and also offers a novel therapeutic intervention for repair of solid organ damage in situ

Polyoxazoline-Based Nanovaccine Synergizes with Tumor-Associated Macrophage Targeting and Anti-PD-1 Immunotherapy against Solid Tumors

Nanovaccines; Tumor immune microenvironment; Tumor-associated macrophagesNanovacunes; Microambient immune tumoral; Macròfags associats al tumorNanovacunas; Microambiente inmune tumoral; Macrófagos asociados al tumorImmune checkpoint blockade reaches remarkable clinical responses. However, even in the most favorable cases, half of these patients do not benefit from these therapies in the long term. It is hypothesized that the activation of host immunity by co-delivering peptide antigens, adjuvants, and regulators of the transforming growth factor (TGF)-β expression using a polyoxazoline (POx)-poly(lactic-co-glycolic) acid (PLGA) nanovaccine, while modulating the tumor-associated macrophages (TAM) function within the tumor microenvironment (TME) and blocking the anti-programmed cell death protein 1 (PD-1) can constitute an alternative approach for cancer immunotherapy. POx-Mannose (Man) nanovaccines generate antigen-specific T-cell responses that control tumor growth to a higher extent than poly(ethylene glycol) (PEG)-Man nanovaccines. This anti-tumor effect induced by the POx-Man nanovaccines is mediated by a CD8+-T cell-dependent mechanism, in contrast to the PEG-Man nanovaccines. POx-Man nanovaccine combines with pexidartinib, a modulator of the TAM function, restricts the MC38 tumor growth, and synergizes with PD-1 blockade, controlling MC38 and CT26 tumor growth and survival. This data is further validated in the highly aggressive and poorly immunogenic B16F10 melanoma mouse model. Therefore, the synergistic anti-tumor effect induced by the combination of nanovaccines with the inhibition of both TAM- and PD-1-inducing immunosuppression, holds great potential for improving immunotherapy outcomes in solid cancer patients.Funding: R.S.-F. and H.F.F. thank the following funding agencies for their generous support: The project that gave rise to these results has received funding from the “la Caixa” Foundation under the grant agreements LCF/PR/HR22/52420016, LCF/PR/HR19/52160021, and LCF/TR/CD20/52700005 (R.S.-F. and H.F.F). H.F.F thanks the generous financial support from The Fundação para a Ciência e Tecnologia-Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES) (EXPL/MED-QUI/1316/2021, PTDC/BTM-SAL/4350/2021, UTAP-EXPL/NPN/0041/2021, UIDB/04138/2020, UIDP/04138/2020). R.S.-F. thanks to the European Research Council (ERC) PoC Grant Agreement no. 101113390 and ERC Advanced Grant Agreement no. 835227, the Israel Science Foundation (1969/18), the Melanoma Research Alliance (Established Investigator Award no. 615808 to R.S.-F.), the Israel Cancer Research Fund (ICRF) Professorship award (no. PROF-18-682), the Morris Kahn Foundation. B.C. is supported by the FCT-MCTES (Ph.D. Fellowship SFRH/BD/131969/2017). The authors also acknowledge the NIH Tetramer Core Facility for the provision of Adpgk tetramers, in addition to the Comparative Pathology Unit of IMM and the Histopathology Facility of IGC for supporting the histopathological study