222 research outputs found

    Comment on "Giant Plasticity of a Quantum Crystal"

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    In their Letter, Haziot et al. [Phys. Rev. Lett. 110 (2013) 035301] report a novel phenomenon of giant plasticity for hcp Helium-4 quantum crystals. They assert that Helium-4 exhibits mechanical properties not found in classical plasticity theory. Specifically, they examine high-quality crystals as a function of temperature and applied strain, where the shear modulus reaches a plateau and dissipation becomes close to zero; both quantities are reported to be independent of stress and strain, implying a reversible dissipation process and quantum tunneling. In this Comment, we show that these signatures can be explained with a classical model of thermally activated dislocation glide without the need to invoke quantum tunneling or dissipationless motion. Recently, we proposed a dislocation glide model in solid Helium-4 containing the dissipation contribution in the presence of other dislocations with qualitatively similar behavior [Zhou et al., Philos. Mag. Lett. 92 (2012) 608].Comment: 1 page, 1 figure, comment; minor revision

    Gestational Weight Gain and Body Mass Index in Children: Results from Three German Cohort Studies

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    Previous studies suggested potential priming effects of gestational weight gain (GWG) on offspring's body composition in later life. However, consistency of these effects in normal weight, overweight and obese mothers is less clear. We combined the individual data of three German cohorts and assessed associations of total and excessive GWG (as defined by criteria of the Institute of Medicine) with offspring's mean body mass index (BMI) standard deviation scores (SDS) and overweight at the age of 5-6 years (total: n = 6,254). Quantile regression was used to examine potentially different effects on different parts of the BMI SDS distribution. All models were adjusted for birth weight, maternal age and maternal smoking during pregnancy and stratified by maternal pre-pregnancy weight status. In adjusted models, positive associations of total and excessive GWG with mean BMI SDS and overweight were observed only in children of non- overweight mothers. For example, excessive GWG was associated with a mean increase of 0.08 (95% CI: 0.01, 0.15) units of BMI SDS (0.13 (0.02, 0.24) kg/m(2) of 'real' BMI) in children of normal-weight mothers. The effects of total and excessive GWG on BMI SDS increased for higher- BMI children of normal-weight mothers. Increased GWG is likely to be associated with overweight in offspring of non-overweight mothers

    Bursts in a fiber bundle model with continuous damage

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    We study the constitutive behaviour, the damage process, and the properties of bursts in the continuous damage fiber bundle model introduced recently. Depending on its two parameters, the model provides various types of constitutive behaviours including also macroscopic plasticity. Analytic results are obtained to characterize the damage process along the plastic plateau under strain controlled loading, furthermore, for stress controlled experiments we develop a simulation technique and explore numerically the distribution of bursts of fiber breaks assuming infinite range of interaction. Simulations revealed that under certain conditions power law distribution of bursts arises with an exponent significantly different from the mean field exponent 5/2. A phase diagram of the model characterizing the possible burst distributions is constructed.Comment: 9 pages, 11 figures, APS style, submitted for publicatio

    Atomic structure of granulin determined from native nanocrystalline granulovirus using an X-ray free-electron laser

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    To understand how molecules function in biological systems, new methods are required to obtain atomic resolution structures from biological material under physiological conditions. Intense femtosecond-duration pulses from X-ray free-electron lasers (XFELs) can outrun most damage processes, vastly increasing the tolerable dose before the specimen is destroyed. This in turn allows structure determination from crystals much smaller and more radiation sensitive than previously considered possible, allowing data collection from room temperature structures and avoiding structural changes due to cooling. Regardless, high-resolution structures obtained from XFEL data mostly use crystals far larger than 1 μm3 in volume, whereas the X-ray beam is often attenuated to protect the detector from damage caused by intense Bragg spots. Here, we describe the 2 Å resolution structure of native nanocrystalline granulovirus occlusion bodies (OBs) that are less than 0.016 μm3 in volume using the full power of the Linac Coherent Light Source (LCLS) and a dose up to 1.3 GGy per crystal. The crystalline shell of granulovirus OBs consists, on average, of about 9,000 unit cells, representing the smallest protein crystals to yield a high-resolution structure by X-ray crystallography to date. The XFEL structure shows little to no evidence of radiation damage and is more complete than a model determined using synchrotron data from recombinantly produced, much larger, cryocooled granulovirus granulin microcrystals. Our measurements suggest that it should be possible, under ideal experimental conditions, to obtain data from protein crystals with only 100 unit cells in volume using currently available XFELs and suggest that single-molecule imaging of individual biomolecules could almost be within reach
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