82 research outputs found
Mean first-passage times for an ac-driven magnetic moment of a nanoparticle
The two-dimensional backward Fokker-Planck equation is used to calculate the
mean first-passage times (MFPTs) of the magnetic moment of a nanoparticle
driven by a rotating magnetic field. It is shown that a magnetic field that is
rapidly rotating in the plane {\it perpendicular} to the easy axis of the
nanoparticle governs the MFPTs just in the same way as a static magnetic field
that is applied {\it along} the easy axis. Within this framework, the features
of the magnetic relaxation and net magnetization of systems composed of
ferromagnetic nanoparticles arising from the action of the rotating field are
revealed.Comment: 7 pages, 1 figur
Stable dynamics in forced systems with sufficiently high/low forcing frequency
We consider a class of parametrically forced Hamiltonian systems with
one-and-a-half degrees of freedom and study the stability of the dynamics when
the frequency of the forcing is relatively high or low. We show that, provided
the frequency of the forcing is sufficiently high, KAM theorem may be applied
even when the forcing amplitude is far away from the perturbation regime. A
similar result is obtained for sufficiently low frequency forcing, but in that
case we need the amplitude of the forcing to be not too large; however we are
still able to consider amplitudes of the forcing which are outside of the
perturbation regime. Our results are illustrated by means of numerical
simulations for the system of a forced cubic oscillator. In addition, we find
numerically that the dynamics are stable even when the forcing amplitude is
very large (beyond the range of validity of the analytical results), provided
the frequency of the forcing is taken correspondingly low.Comment: 12 pages, 3 figures, 2 table
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΌΠ΅ΠΊΡΠΈΠ΄ΠΎΠ»Π° Π½Π° ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΡΡ ΠΈ ΡΠΌΡΡΠ²Π΅Π½Π½ΡΡ ΡΠ°Π±ΠΎΡΠΎΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΏΡΠΈ ΡΡΡΠ΅ΡΡΠΎΠ³Π΅Π½Π½ΡΡ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡΡ Π² ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ΅
The effect of Mexidol on physical performance of mice under the extreme conditions of the weight-loaded forced swim test and on the mental performance of rats under the conditions of a neurosis-like state caused by a functional disturbance of a defensive instrumental conditioned active avoidance reflex was studied. A single dose (50 and 100 mg/kg) or a subchronic regimen (100 mg/kg) of Mexidol administered intrapertoneally enhances the physical performance of mice similarly to mildronate (100 mg/kg). Mexidol improves the rate of operant conditioning, the preservation of the memory trace and its restoration after single or multiple instances of disruption of the conditioned active avoidance reflex, and its effect does not differ from the effect of the comparison drug piracetam (300 mg/kg).ΠΠ·ΡΡΠ΅Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΡ ΠΌΠ΅ΠΊΡΠΈΠ΄ΠΎΠ»Π° Π½Π° ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΡΡ ΡΠ°Π±ΠΎΡΠΎΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΌΡΡΠ΅ΠΉ Π² ΡΠΊΡΡΡΠ΅ΠΌΠ°Π»ΡΠ½ΡΡ
ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΡΠ΅ΡΡΠ° Β«ΠΠ»Π°Π²Π°Π½ΠΈΠ΅ Ρ Π³ΡΡΠ·ΠΎΠΌΒ» ΠΈ Π½Π° ΡΠΌΡΡΠ²Π΅Π½Π½ΡΡ ΡΠ°Π±ΠΎΡΠΎΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΊΡΡΡ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π½Π΅Π²ΡΠΎΠ·ΠΎΠΏΠΎΠ΄ΠΎΠ±Π½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ, Π²ΡΠ·Π²Π°Π½Π½ΠΎΠ³ΠΎ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΌ Π½Π°ΡΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΠΎΡΠΎΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΡΠ»Π΅ΠΊΡΠ° Π°ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΈΠ·Π±Π΅Π³Π°Π½ΠΈΡ. ΠΠΎΠΊΠ°Π·Π°Π½Π° ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΌΠ΅ΠΊΡΠΈΠ΄ΠΎΠ»Π° ΠΊΠ°ΠΊ ΠΏΡΠΈ ΠΎΠ΄Π½ΠΎΠΊΡΠ°ΡΠ½ΠΎΠΌ (50 ΠΈ 100 ΠΌΠ³/ΠΊΠ³), ΡΠ°ΠΊ ΠΈ ΠΏΡΠΈ ΡΡΠ±Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌ Π²Π½ΡΡΡΠΈΠ±ΡΡΡΠΈΠ½Π½ΠΎΠΌ Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ (100 ΠΌΠ³/ΠΊΠ³) ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°ΡΡ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΡΡ ΡΠ°Π±ΠΎΡΠΎΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΌΡΡΠ΅ΠΉ, ΡΠΎΠΏΠΎΡΡΠ°Π²ΠΈΠΌΡΡ ΠΏΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Ρ ΠΌΠΈΠ»Π΄ΡΠΎΠ½Π°ΡΠΎΠΌ (100 ΠΌΠ³/ΠΊΠ³). Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΌΠ΅ΠΊΡΠΈΠ΄ΠΎΠ»Π° ΡΠ»ΡΡΡΠ°ΡΡ ΡΠΊΠΎΡΠΎΡΡΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ»ΠΎΠ²Π½ΡΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ, ΡΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΠ΅ ΠΏΠ°ΠΌΡΡΠ½ΠΎΠ³ΠΎ ΡΠ»Π΅Π΄Π° ΠΈ Π΅Π³ΠΎ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΠΏΡΠΈ ΠΎΠ΄Π½ΠΎΠΊΡΠ°ΡΠ½ΡΡ
ΠΈ ΠΏΠΎΠ²ΡΠΎΡΠ½ΡΡ
ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
Π½Π°ΡΡΡΠ΅Π½ΠΈΡΡ
ΡΡΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΡΠ΅ΡΠ»Π΅ΠΊΡΠ° Π°ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΈΠ·Π±Π΅Π³Π°Π½ΠΈΡ, Π½Π΅ ΠΎΡΠ»ΠΈΡΠ°ΡΡΠ°ΡΡΡ ΠΏΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΎΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΠΏΠΈΡΠ°ΡΠ΅ΡΠ°ΠΌΠ° (300 ΠΌΠ³/ΠΊΠ³)
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΡΡΠΈΡΡΠ°Π·ΠΈΠ½Π° Π½Π° ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ² Π°ΡΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΏΠ΅ΠΊΡΡΠ° Ρ ΠΊΡΡΡ Ρ ΡΠ΅ΡΠ°Π»ΡΠ½ΡΠΌ Π²Π°Π»ΡΠΏΡΠΎΠ°ΡΠ½ΡΠΌ ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ
The effect of triftazin (trifluoperazine) on social interaction abnormalities as a main feature of autism spectrum disorders, exploratory behavior and learning capacity was studied in rats with fetal valproatate syndrome. It was shown that triftazin at a dose of 0,35 mg/kg does not affect the deficit of social interaction, spatial learning or memory but improves exploratory activity by decreasing anxiety in rats with fetal valproate syndrome.ΠΠ° ΠΌΠΎΠ΄Π΅Π»ΠΈ ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π²Π°Π»ΡΠΏΡΠΎΠ°ΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° Ρ ΠΊΡΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΡΠΈΡΡΠ°Π·ΠΈΠ½Π° Π½Π° Π½Π°ΡΡΡΠ΅Π½ΠΈΠ΅ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΊΠ°ΠΊ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²Π° Π°ΡΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΏΠ΅ΠΊΡΡΠ°, Π° ΡΠ°ΠΊΠΆΠ΅ Π½Π° ΠΎΡΠΈΠ΅Π½ΡΠΈΡΠΎΠ²ΠΎΡΠ½ΠΎ-ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠ΅ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΈ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΊ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΡΠΈΡΡΠ°Π·ΠΈΠ½ Π² Π΄ΠΎΠ·Π΅ 0,35 ΠΌΠ³/ΠΊΠ³ Π½Π΅ Π²Π»ΠΈΡΠ΅Ρ Π½Π° Π΄Π΅ΡΠΈΡΠΈΡ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ ΠΈ ΠΏΠ°ΠΌΡΡΠΈ, Π½ΠΎ ΡΠ»ΡΡΡΠ°Π΅Ρ ΠΎΡΠΈΠ΅Π½ΡΠΈΡΠΎΠ²ΠΎΡΠ½ΠΎ-ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π·Π° ΡΡΡΡ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΡΠ΅Π²ΠΎΠΆΠ½ΠΎΡΡΠΈ Ρ ΠΊΡΡΡ Ρ ΡΠ΅ΡΠ°Π»ΡΠ½ΡΠΌ Π²Π°Π»ΡΠΏΡΠΎΠ°ΡΠ½ΡΠΌ ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ
Volume element structure and roton-maxon-phonon excitations in superfluid helium beyond the Gross-Pitaevskii approximation
We propose a theory which deals with the structure and interactions of volume
elements in liquid helium II. The approach consists of two nested models linked
via parametric space. The short-wavelength part describes the interior
structure of the fluid element using a non-perturbative approach based on the
logarithmic wave equation; it suggests the Gaussian-like behaviour of the
element's interior density and interparticle interaction potential. The
long-wavelength part is the quantum many-body theory of such elements which
deals with their dynamics and interactions. Our approach leads to a unified
description of the phonon, maxon and roton excitations, and has noteworthy
agreement with experiment: with one essential parameter to fit we reproduce at
high accuracy not only the roton minimum but also the neighboring local maximum
as well as the sound velocity and structure factor.Comment: 9 pages, 6 figure
ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΏΠ°ΡΠΊΠΈΠ½ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ, ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈ Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ° Π³ΠΈΠΌΠ°Π½ΡΠ°Π½Π° ΠΠΠ-1058 Π² ΡΡΠ°Π²Π½Π΅Π½ΠΈΠΈ Ρ Π³ΠΈΠΌΠ°Π½ΡΠ°Π½ΠΎΠΌ
Antiparkinsonian, anti-inflammatory and analgesic activity of ADK-1058, a metabolite of hemantane, was investigated in comparison with hemantane at the effective dose of 20 mg/kg. ADK-1058 exhibits a minor antiparkinsonian effect by reducing the severity of oLigokinesia in C57BL/6 mice with MPTP-induced parkinsonian syndrome. ADK-1058 exhibits anti-inflammatory activity in the model of acetic acid peritonitis, but has no analgesic effect in visceral or somatic pain in mice. Effects of ADK-1058 at the dose of 20 mg/kg do not exceed antiparkinsonian, anti-inflammatory or analgesic effects of hemantane at the dose of 20 mg/kg.Π ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΌ Π°ΡΠΏΠ΅ΠΊΡΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΏΠ°ΡΠΊΠΈΠ½ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ, ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ±ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ° Π³ΠΈΠΌΠ°Π½ΡΠ°Π½Π° ΠΠΠ-1058 ΠΈ Π³ΠΈΠΌΠ°Π½ΡΠ°Π½Π° Π² ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ Π΄ΠΎΠ·Π΅ 20 ΠΌΠ³/ΠΊΠ³. ΠΠΠ-1058 ΠΏΡΠΎΡΠ²Π»ΡΠ΅Ρ ΡΠ»Π°Π±ΡΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΏΠ°ΡΠΊΠΈΠ½ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ, ΡΠ½ΠΈΠΆΠ°Ρ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡ ΠΎΠ»ΠΈΠ³ΠΎΠΊΠΈΠ½Π΅Π·ΠΈΠΈ Ρ ΠΌΡΡΠ΅ΠΉ Π‘57B1/6 Ρ ΠΠ€Π’Π-Π²ΡΠ·Π²Π°Π½Π½ΡΠΌ ΠΏΠ°ΡΠΊΠΈΠ½ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ. ΠΠΠ-1058 ΠΏΡΠΎΡΠ²Π»ΡΠ΅Ρ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π½Π° ΠΌΠΎΠ΄Π΅Π»ΠΈ ΡΠΊΡΡΡΠ½ΠΎΠΊΠΈΡΠ»ΠΎΠ³ΠΎ ΠΏΠ΅ΡΠΈΡΠΎΠ½ΠΈΡΠ°, Π½ΠΎ Π½Π΅ ΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ Π²ΠΈΡΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΈ ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±ΠΎΠ»ΠΈ. ΠΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡ Π³ΠΈΠΌΠ°Π½ΡΠ°Π½Π° ΠΠΠ-1058 (20 ΠΌΠ³/ΠΊΠ³) ΠΏΠΎ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΏΠ°ΡΠΊΠΈΠ½ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌΡ, ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΌΡ ΠΈ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ±ΠΎΠ»Π΅Π²ΠΎΠΌΡ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π½Π΅ ΠΏΡΠ΅Π²ΠΎΡΡ
ΠΎΠ΄ΠΈΡ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π³ΠΈΠΌΠ°Π½ΡΠ°Π½Π° (20 ΠΌΠ³/ΠΊΠ³)
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ Π³ΠΈΠΌΠ°Π½ΡΠ°Π½Π° Π½Π° ΡΡΠΎΠ²Π΅Π½Ρ ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² ΠΏΠ΅ΡΠ΅ΠΊΠΈΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ² Π² Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠΌ ΠΌΠΎΠ·Π³Π΅ ΠΏΡΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΌ ΠΏΠ°ΡΠΊΠΈΠ½ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ΅
In two animaL modeLs of parkinsonian syndrome - induced by 1-methyL-4-phenyL-1,2,3,6-tetrahydropiridine (MPTP) in C57BL/6 mice and 6-hydroxidopamine (6-OHDA) in rats noveL antiparkinsonian drug hemantane was shown to reduce the increase of brain LeveL of Lipid peroxidation caused by both neurotoxines. In prefrontaL cortex and striatum of mice which were treated with hemantane 10 mg/kg 5 days before MPTP and 5 days together with MPTP and in rats which received hemantane during 21 days after 6-OHDA injection in mediaL forebrain bundLe the LeveLs of maLondiaLdehyde and conjugated dienes were significantLy Lower than in untreated animaLs. The data obtained is consistent with antioxidant properties of hemantane.ΠΠ° Π΄Π²ΡΡ
ΠΌΠΎΠ΄Π΅Π»ΡΡ
ΠΏΠ°ΡΠΊΠΈΠ½ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° (ΠΠ‘), ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ 1-ΠΌΠ΅ΡΠΈΠ»-4-ΡΠ΅Π½ΠΈΠ»-1,2,3,6-ΡΠ΅ΡΡΠ°Π³ΠΈΠ΄ΡΠΎΠΏΠΈΡΠΈΠ΄ΠΈΠ½ΠΎΠΌ (ΠΠ€Π’Π) Ρ ΠΌΡΡΠ΅ΠΉ C57BL/6 ΠΈ 6-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΠ΄ΠΎΡΠ°ΠΌΠΈΠ½ΠΎΠΌ (6-ΠΠΠΠ) Ρ ΠΊΡΡΡ, ΠΏΠΎΠΊΠ°Π·Π°Π½Π° ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ Π½ΠΎΠ²ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΏΠ°ΡΠΊΠΈΠ½ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° Π³ΠΈΠΌΠ°Π½ΡΠ°Π½Π° Π² ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ Π΄ΠΎΠ·Π΅ 10 ΠΌΠ³/ΠΊΠ³ ΠΏΡΠΈ Π΄Π²ΡΡ
ΡΠ΅ΠΆΠΈΠΌΠ°Ρ
Π²Π²Π΅Π΄Π΅Π½ΠΈΡ (5 Π΄Π½Π΅ΠΉ Π΄ΠΎ Π½Π΅ΠΉΡΠΎΡΠΎΠΊΡΠΈΠ½Π° ΠΠ€Π’Π ΠΈ ΡΠΎΠ²ΠΌΠ΅ΡΡΠ½ΠΎ Ρ Π½ΠΈΠΌ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 5 Π΄Π½Π΅ΠΉ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠΈ Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 21 Π΄Π½Ρ Π½Π° ΡΠΎΠ½Π΅ ΡΠ°Π·Π²ΠΈΠ²Π°ΡΡΠ΅Π³ΠΎΡΡ 6-ΠΠΠΠ ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΠ‘) ΠΎΡΠ»Π°Π±Π»ΡΡΡ Π²ΡΠ·ΡΠ²Π°Π΅ΠΌΡΡ Π½Π΅ΠΉΡΠΎΡΠΎΠΊΡΠΈΠ½Π°ΠΌΠΈ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ ΠΏΠ΅ΡΠ΅ΠΊΠΈΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ². ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π³ΠΈΠΌΠ°Π½ΡΠ°Π½Π° ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΠ»ΠΎ ΠΊ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΡΠΎΠ²Π½Π΅ΠΉ ΠΌΠ°Π»ΠΎΠ½ΠΎΠ²ΠΎΠ³ΠΎ Π°Π»ΡΠ΄Π΅Π³ΠΈΠ΄Π° ΠΈ Π΄ΠΈΠ΅Π½ΠΎΠ²ΡΡ
ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΎΠ² Π²ΠΎ ΡΡΠΎΠ½ΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΊΠΎΡΠ΅ ΠΈ ΡΡΡΠΈΠ°ΡΡΠΌΠ΅. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΡΠΎΠ³Π»Π°ΡΡΡΡΡΡ Ρ ΡΠ°Π½Π΅Π΅ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π½ΡΠΌΠΈ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΡΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ Π³ΠΈΠΌΠ°Π½ΡΠ°Π½Π°
Biogeochemistry and limnology in Antarctic subglacial weathering: molecular evidence of the linkage between subglacial silica input and primary producers in a perennially ice-covered lake
ELECTROPHYSIOLOGICAL MECHANISMS OF ANTIEPILEPTIC ACTIONS REALIZATION OF BEPRODON
The purpose of this research was to study electric and physiological mechanisms of the achievement of the antoconvulsant effect of the new original beprodon combination together with determination of determinant brain structures β therapeutic targets.Materials and Methods. Partial (focal) and secondary generalized convulsions were generated using the method of creation of a chronic epileptogenic focus, caused by the cobalt application on ratsβ brain.Results: it was revealed, that at the first stage of the epileptic system (ES) beprodone is targeted to cortical focuses, and at the second stage β to subcortical focuses, generating epileptic activities. Conclusion: the beprodone effect depends on the stage of the epileptic system development and is targeted to determinant focuses
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