EVALUATING ROUTE LEARNING PERFORMANCE OF OLDER AND YOUNGER ADULTS IN DIFFERENTLY-DESIGNED VIRTUAL ENVIRONMENTS: A TASK-DIFFERENTIAL ANALYSIS

Navigating in unfamiliar environments is a complex task that requires considerable cognitive resources to memorize (and eventually learn) a route. In general, virtual environments (VEs) can be useful tools in training for route learning and improving route recall. However, the visual information presented in VEs, that is, what we choose to present in a virtual scene, can strongly affect the ability to recall a route. This is especially relevant when we consider individual differences, and people’s varying abilities to navigate effectively. Taking various cognitive processes involved in route learning into account, we designed a multi-level experiment that examines route recall effectiveness in a navigation context. We conceptualized that the participants would have to recall information related to the route that is demanding on primarily visual, spatial, or visuospatial memory systems. Furthermore, because there is a clear link between memory capacity and ageing; we conducted our experiment with two different age groups (total 81 participants: 42 young people aged 20–30 yo and 39 older people aged 65–76 yo). We also measured participants’ spatial abilities and visuospatial memory capacity for control purposes. After experiencing a pre-determined route in three different VEs (that we varied in levels of visual realism, and named as AbstractVE, MixedVE, and RealisticVE), each participant solved a list of tasks that was designed to measure visual, spatial, and visuospatial recall of the scene elements and information about the route. Participants solved these tasks immediately after experiencing the route in each VE, as well as after a week, thus we could measure ‘learning’ (delayed recall). Results from our study confirm the well-known decline in recall with age (young vs. older), provide new information regarding memorability of routes and VE scene elements over time (immediate vs. delayed), and most importantly demonstrate the crucial role the visual design decisions play in route learning and memorability of visuospatial displays

Virtual environments as memory training devices in navigational tasks for older adults

Cognitive training approaches using virtual environments (VEs) might counter age-related visuospatial memory decline and associated difficulties in wayfinding. However, the effects of the visual design of a VE in route learning are not fully understood. Therefore, we created a custom-designed VE optimized for route learning, with adjusted levels of realism and highlighted landmark locations (MixedVE). Herein we tested participants’ route recall performance in identifying direction of turn at the intersection with this MixedVE against two baseline alternatives (AbstractVE, RealisticVE). An older vs. a younger group solved the tasks in two stages (immediate vs. delayed recall by one week). Our results demonstrate that the MixedVE facilitates better recall accuracy than the other two VEs for both age groups. Importantly, this pattern persists a week later. Additionally, our older participants were mostly overconfident in their route recall performance, but the MixedVE moderated this potentially detrimental overconfidence. Before the experiment, participants clearly preferred the RealisticVE, whereas after the experiment, most of the younger, and many of the older participants, preferred the MixedVE. Taken together, our findings provide insights into the importance of tailoring visualization design in route learning with VEs. Furthermore, we demonstrate the great potential of the MixedVE and by extension, of similar VEs as memory training devices for route learning, especially for older participants

Fetal-derived macrophages dominate in adult mammary glands

Macrophages serve multiple functions including immune regulation, morphogenesis, tissue homeostasis and healing reactions. The current paradigm holds that mammary gland macrophages first arise postnatally during the prepubertal period from the bone marrow-derived monocytes. Here we delineate the origins of tissue-resident mammary gland macrophages using high-dimension phenotypic analyses, cell-fate mapping experiments, gene-deficient mice lacking selective macrophage subtypes, and antibody-based depletion strategies. We show that tissue-resident macrophages are found in mammary glands already before birth, and that the yolk sac-derived and fetal liver-derived macrophages outnumber the adult-derived macrophages in the mammary gland also in the adulthood. In addition, fetal-derived mammary gland macrophages have a characteristic phenotype, display preferential periductal and perivascular localization, and are highly active in scavenging. These findings identify fetal-derived macrophages as the predominant leukocyte type in the adult mammary gland stroma, and reveal previously unknown complexity of macrophage biology in the breast

Virtual environments as memory training devices in navigational tasks for older adults

Cognitive training approaches using virtual environments (VEs) might counter age-related visuospatial memory decline and associated difficulties in wayfinding. However, the effects of the visual design of a VE in route learning are not fully understood. Therefore, we created a custom-designed VE optimized for route learning, with adjusted levels of realism and highlighted landmark locations (MixedVE). Herein we tested participants’ route recall performance in identifying direction of turn at the intersection with this MixedVE against two baseline alternatives (AbstractVE, RealisticVE). An older vs. a younger group solved the tasks in two stages (immediate vs. delayed recall by one week). Our results demonstrate that the MixedVE facilitates better recall accuracy than the other two VEs for both age groups. Importantly, this pattern persists a week later. Additionally, our older participants were mostly overconfident in their route recall performance, but the MixedVE moderated this potentially detrimental overconfidence. Before the experiment, participants clearly preferred the RealisticVE, whereas after the experiment, most of the younger, and many of the older participants, preferred the MixedVE. Taken together, our findings provide insights into the importance of tailoring visualization design in route learning with VEs. Furthermore, we demonstrate the great potential of the MixedVE and by extension, of similar VEs as memory training devices for route learning, especially for older participants.ISSN:2045-232