Own Way Girl

OWN WAY GIRL is a memoir about growing up in a Caribbean family of women. The memoir covers the narrator’s tentative beginnings as she was adopted by a single woman in Barbados at three months old until she turns sixteen and learns the secret that has weighed heavily on both her birth and adopted mother. This memoir explores the narrator’s layered relationship with her adopted mother, her complicated relationship with her birth mother, as well family dynamics with her adopted grandmother and adopted sisters. It interrogates the nature of kin and blood ties and probes the ultimate question of what makes a family. This memoir also touches on the themes of culture, class, cultural capital, domestic violence, death, and a young girl\u27s quest for agency

Stable and unstable attractors in Boolean networks

Boolean networks at the critical point have been a matter of debate for many years as, e.g., scaling of number of attractor with system size. Recently it was found that this number scales superpolynomially with system size, contrary to a common earlier expectation of sublinear scaling. We here point to the fact that these results are obtained using deterministic parallel update, where a large fraction of attractors in fact are an artifact of the updating scheme. This limits the significance of these results for biological systems where noise is omnipresent. We here take a fresh look at attractors in Boolean networks with the original motivation of simplified models for biological systems in mind. We test stability of attractors w.r.t. infinitesimal deviations from synchronous update and find that most attractors found under parallel update are artifacts arising from the synchronous clocking mode. The remaining fraction of attractors are stable against fluctuating response delays. For this subset of stable attractors we observe sublinear scaling of the number of attractors with system size.Comment: extended version, additional figur

Phase transition in a class of non-linear random networks

We discuss the complex dynamics of a non-linear random networks model, as a function of the connectivity k between the elements of the network. We show that this class of networks exhibit an order-chaos phase transition for a critical connectivity k = 2. Also, we show that both, pairwise correlation and complexity measures are maximized in dynamically critical networks. These results are in good agreement with the previously reported studies on random Boolean networks and random threshold networks, and show once again that critical networks provide an optimal coordination of diverse behavior.Comment: 9 pages, 3 figures, revised versio

Attractor and Basin Entropies of Random Boolean Networks Under Asynchronous Stochastic Update

We introduce a numerical method to study random Boolean networks with asynchronous stochas- tic update. Each node in the network of states starts with equal occupation probability and this probability distribution then evolves to a steady state. Nodes left with finite occupation probability determine the attractors and the sizes of their basins. As for synchronous update, the basin entropy grows with system size only for critical networks, where the distribution of attractor lengths is a power law. We determine analytically the distribution for the number of attractors and basin sizes for frozen networks with connectivity K = 1.Comment: 5 pages, 3 figures, in submissio

The dynamics of critical Kauffman networks under asynchronous stochastic update

We show that the mean number of attractors in a critical Boolean network under asynchronous stochastic update grows like a power law and that the mean size of the attractors increases as a stretched exponential with the system size. This is in strong contrast to the synchronous case, where the number of attractors grows faster than any power law.Comment: submitted to PR

The Role of HDAC6 in Cancer

Histone deacetylase 6 (HDAC6), a member of the HDAC family whose major substrate is α-tubulin, has become a target for drug development to treat cancer due to its major contribution in oncogenic cell transformation. Overexpression of HDAC6 correlates with tumorigenesis and improved survival; therefore, HDAC6 may be used as a marker for prognosis. Previous work demonstrated that in multiple myeloma cells, inhibition of HDAC6 results in apoptosis. Furthermore, HDAC6 is required for the activation of heat-shock factor 1 (HSF1), an activator of heat-shock protein encoding genes (HSPs) and CYLD, a cylindromatosis tumor suppressor gene. HDAC6 contributes to cancer metastasis since its upregulation increases cell motility in breast cancer MCF-7 cells and its interaction with cortactin regulates motility. HDAC6 also affects transcription and translation by regulating the heat-shock protein 90 (Hsp90) and stress granules (SGs), respectively. This review will discuss the role of HDAC6 in the pathogenesis and treatment of cancer

Three-dimensional numerical simulation of 1GeV/Nucleon U92+ impact against atomic hydrogen

The impact of 1GeV/Nucleon U92+ projectiles against atomic hydrogen is studied by direct numerical resolution of the time-dependent wave equation for the atomic electron on a three-dimensional Cartesian lattice. We employ the fully relativistic expressions to describe the electromagnetic fields created by the incident ion. The wave equation for the atom interacting with the projectile is carefully derived from the time-dependent Dirac equation in order to retain all the relevant terms.Comment: 12 pages and 7 figures included in the tex

Critical Kauffman networks under deterministic asynchronous update

We investigate the influence of a deterministic but non-synchronous update on Random Boolean Networks, with a focus on critical networks. Knowing that ``relevant components'' determine the number and length of attractors, we focus on such relevant components and calculate how the length and number of attractors on these components are modified by delays at one or more nodes. The main findings are that attractors decrease in number when there are more delays, and that periods may become very long when delays are not integer multiples of the basic update step.Comment: 8 pages, 3 figures, submitted to a journa