148 research outputs found
Revisiting the 'LSND anomaly' II: critique of the data analysis
This paper, together with a preceding paper, questions the so-called 'LSND
anomaly': a 3.8 sigma excess of antielectronneutrino interactions over standard
backgrounds, observed by the LSND Collaboration in a beam dump experiment with
800 MeV protons. That excess has been interpreted as evidence for the
antimuonneutrino to antielectronneutrino oscillation in the \Deltam2 range from
0.2 eV2 to 2 eV2. Such a \Deltam2 range is incompatible with the widely
accepted model of oscillations between three light neutrino species and would
require the existence of at least one light 'sterile' neutrino. In a preceding
paper, it was concluded that the estimates of standard backgrounds must be
significantly increased. In this paper, the LSND Collaboration's estimate of
the number of antielectronneutrino interactions followed by neutron capture,
and of its error, is questioned. The overall conclusion is that the
significance of the 'LSND anomaly' is not larger than 2.3 sigma.Comment: 30 pages, 16 figures, 6 table
Why the paper CERN-PH-EP-2009-015 (arXiv:0903.4762) is scientifically unacceptable
The paper CERN-PH-EP-2009-015 (arXiv:0903.4762) by A. Bagulya et al. violates
standards of quality of work and scientific ethics on several counts. The paper
contains assertions that contradict established detector physics. The paper
falls short of proving the correctness of the authors' concepts and results.
The paper ignores or quotes misleadingly pertinent published work. The paper
ignores the fact that the authors' concepts and results have already been shown
wrong in the published literature. The authors seem unaware that cross-section
results from the 'HARP Collaboration' that are based on the paper's concepts
and algorithms are in gross disagreement with the results of a second analysis
of the same data, and with the results of other experiments.Comment: 8 pages, 3 figure
Reply to 'Corrections to the HARP-CDP Analysis of the LSND Neutrino Oscillation Backgrounds'
The alleged mistakes in recent papers that reanalyze the backgrounds to the
'LSND anomaly' do not exist. We maintain our conclusion that the significance
of the 'LSND anomaly' is not 3.8 sigma but not larger than 2.3 sigma.Comment: 3 page
Cross-sections of large-angle hadron production in proton- and pion-nucleus interactions VII: tin nuclei and beam momenta from \pm3 GeV/c to \pm15 GeV/c
We report on double-differential inclusive cross-sections of the production
of secondary protons, charged pions, and deuterons, in the interactions with a
5% nuclear interaction length thick stationary tin target, of proton and pion
beams with momentum from \pm3 GeV/c to \pm15 GeV/c. Results are given for
secondary particles with production angles between 20 and 125 degrees.
Cross-sections on tin nuclei are compared with cross-sections on beryllium,
carbon, copper, tantalum and lead nuclei.Comment: 68 pages, 13 figure
Comparison of Geant4 hadron generation with data from the interactions with beryllium nuclei of +8.9 GeV/c protons and pions, and of -8 GeV/c pions
Hadron generation in the Geant4 simulation tool kit is compared with
inclusive spectra of secondary protons and pions from the interactions with
beryllium nuclei of +8.9 GeV/c protons and pions, and of -8.0 GeV/c pions. The
data were taken in 2002 at the CERN Proton Synchrotron with the HARP
spectrometer. We report on significant disagreements between data and simulated
data especially in the polar-angle distributions of secondary protons and
pions.Comment: 15 pages, 13 figure
Cross-Sections of Large-Angle Hadron Production in Proton- and Pion-Nucleus Interactions V: Lead Nuclei and Beam Momenta from +/-3 Gev/c to +/-15 Gev/c
We report on double-differential inclusive cross-sections of the production
of secondary protons, charged pions, and deuterons, in the interactions with a
5% nuclear interaction length thick stationary lead target, of proton and pion
beams with momentum from +/-3 GeV/c to +/-15 GeV/c. Results are given for
secondary particles with production angles 20 to 125 degrees. Cross-sections on
lead nuclei are compared with cross-sections on beryllium, copper, and tantalum
nuclei.Comment: 67 pages, 13 figures, 47 table
Sequential Metabolism of 7-Dehydrocholesterol to Steroidal 5,7-Dienes in Adrenal Glands and Its Biological Implication in the Skin
Since P450scc transforms 7-dehydrocholesterol (7DHC) to 7-dehydropregnenolone (7DHP) in vitro, we investigated sequential 7DHC metabolism by adrenal glands ex vivo. There was a rapid, time- and dose-dependent metabolism of 7DHC by adrenals from rats, pigs, rabbits and dogs with production of more polar 5,7-dienes as detected by RP-HPLC. Based on retention time (RT), UV spectra and mass spectrometry, we identified the major products common to all tested species as 7DHP, 22-hydroxy-7DHC and 20,22-dihydroxy-7DHC. The involvement of P450scc in adrenal metabolic transformation was confirmed by the inhibition of this process by DL-aminoglutethimide. The metabolism of 7DHC with subsequent production of 7DHP was stimulated by forscolin indicating involvement of cAMP dependent pathways. Additional minor products of 7DHC metabolism that were more polar than 7DHP were identified as 17-hydroxy-7DHP (in pig adrenals but not those of rats) and as pregna-4,7-diene-3,20-dione (7-dehydroprogesterone). Both products represented the major identifiable products of 7DHP metabolism in adrenal glands. Studies with purified enzymes show that StAR protein likely transports 7DHC to the inner mitochondrial membrane, that 7DHC can compete effectively with cholesterol for the substrate binding site on P450scc and that the catalytic efficiency of 3βHSD for 7DHP (Vm/Km) is 40% of that for pregnenolone. Skin mitochondria are capable of transforming 7DHC to 7DHP and the 7DHP is metabolized further by skin extracts. Finally, 7DHP, its photoderivative 20-oxopregnacalciferol, and pregnenolone exhibited biological activity in skin cells including inhibition of proliferation of epidermal keratinocytes and melanocytes, and melanoma cells. These findings define a novel steroidogenic pathway: 7DHCâ22(OH)7DHCâ20,22(OH)27DHCâ7DHP, with potential further metabolism of 7DHP mediated by 3βHSD or CYP17, depending on mammalian species. The 5â7 dienal intermediates of the pathway can be a source of biologically active vitamin D3 derivatives after delivery to or production in the skin, an organ intermittently exposed to solar radiation
The HARP Resistive Plate Chambers: Characteristics and Physics Performance
The HARP Resistive Plate Chamber (RPC) system was designed for time-of-flight measurement in the large-angle acceptance region of the HARP spectrometer. It comprised 46 four-gap glass RPCs covering an area of _8m2. The design of the RPCs, their operation, intrinsic properties, and system performance are described. The intrinsic time resolution of the RPCs is better than 130 ps leading to a system time resolution of _175 ps
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