Enhancement of COPD biological networks using a web-based collaboration interface

The construction and application of biological network models is an approach that offers a holistic way to understand biological processes involved in disease. Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory disease of the airways for which therapeutic options currently are limited after diagnosis, even in its earliest stage. COPD network models are important tools to better understand the biological components and processes underlying initial disease development. With the increasing amounts of literature that are now available, crowdsourcing approaches offer new forms of collaboration for researchers to review biological findings, which can be applied to the construction and verification of complex biological networks. We report the construction of 50 biological network models relevant to lung biology and early COPD using an integrative systems biology and collaborative crowd-verification approach. By combining traditional literature curation with a data-driven approach that predicts molecular activities from transcriptomics data, we constructed an initial COPD network model set based on a previously published non-diseased lung-relevant model set. The crowd was given the opportunity to enhance and refine the networks on a website ( https://bionet.sbvimprover.com/) and to add mechanistic detail, as well as critically review existing evidence and evidence added by other users, so as to enhance the accuracy of the biological representation of the processes captured in the networks. Finally, scientists and experts in the field discussed and refined the networks during an in-person jamboree meeting. Here, we describe examples of the changes made to three of these networks: Neutrophil Signaling, Macrophage Signaling, and Th1-Th2 Signaling. We describe an innovative approach to biological network construction that combines literature and data mining and a crowdsourcing approach to generate a comprehensive set of COPD-relevant models that can be used to help understand the mechanisms related to lung pathobiology. Registered users of the website can freely browse and download the networks

Selection of the optimal version of the rolling rings of stand no. 7 of mill 150 of OJSC “BSW Management Company of Holding “BMC” from various types of high-speed steel, providing the best indicator of operational durability

Rolling rings as an important element of the rolling mill belong to the category of replaceable equipment, the quality of performance of which affects a number of operational characteristics, as well as the quality of rolled products. The material from which the rolling ring of the stand No. 7 is made must have the appropriate properties capable of perceiving high thermal loads for a long period of time without destruction, chipping and significant development of calibers. In this regard, there is a need to select the optimal option for the manufacture of rolling rings that can withstand such loads for a sufficiently long period of time. The study of the causes of destruction of the rolling ring 450×242×100 mm of high-speed steel, used at OJSC «BSW – Management Company of the Holding «BMC» in the cage number 7 mill 150 rolling shop. The results of metallographic studies of the microstructure and chemical composition of fragments of the destroyed rolling ring are presented. A detailed study and comparative analysis of the chemical composition and microstructure of samples of similar rings made of high-speed steel from two different suppliers, which showed high results in durability during operation, was carried out

STUDY OF THE LATTICE CRACKS TRANSFORMATION IN THE HOT-ROLLED SEAMLESS PIPES

The transformation of the steel-smelting defect «netlike cracks» at all stages of processing from continuous casting to finished product was studied

RESEARCH OF DEFECTS OF CONTINUOUS CAST BILLET WITH DIAMETER 200 MM AND REASONS OF THEIR ORIGIN IN CONDITIONS OF JSC «BMZ»

Defects of continuous cast still billets, which run because of the deviation from the given technology, are investigated and causes of their forming are established in JSC “BSW”

DEVELOPMENT AND CREATION OF THE «CLASSIFICATION OF DEFECTS OF HOT ROLLED SEAMLESS PIPE PRODUCTION OF JSC «BMZ – MANAGEMENT COMPANY OF HOLDING «BMK»

With the development of a new process for the production of seamless hot-rolled pipes, specialists of the enterprise encountered difficulties in determining the causes of unsatisfactory quality of pipes, determining their nature and causes. In this regard, this article contains created and developed «Classification of defects of hot rolled seamless pipes made of OJSC «BSW – management company of «BMC» holding»

RESEARCH OF INFLUENCE OF OXIDATION ON CONDITION OF THE BLANKS SURFACE FOR IMPROVEMENT OF QUALITY OF HOT­ROLLED SEAMLESS PIPES

It is shown that research of scaling on the uninterruptedly-casted and the hot-rolled blanks, enabling to improve quality of production and due to that to increase its competitiveness, is actua

DEFECT «TRACKS FROM CUTS ON ROLLERS» ON THE EXTERNAL SURFACE OF SEAMLESS HOTROLLED PIPES

The defect, revealed on an external surface of sleeves at piercing of slug at piercing mill of helical rolling of construction «СТР100VD» with twin-pillar rollers of mushroom shape and guiding disks of Disher, is considered