2-[3-(Methyl­diphenyl­silyl)prop­yl]isoindoline-1,3-dione

In the title compound, C24H23NO2Si, the dihedral angle between the planes of the phenyl rings attached to the Si atom is 80.78 (10)°. In the crystal, the mol­ecules form sheets lying perpendicular to [101] via C—H⋯O inter­actions. These sheets are stacked and linked in a three-dimensional framework by additional C—H⋯O inter­actions in the [10] direction

2-[2-(Trimethyl­silyl)eth­yl]isoindoline-1,3-dione

In the course of our studies of silicon-containing anti­cancer compounds, the title compound, C13H17NO2Si, was synthesized. The geometrical parameters including the geometry about the Si atom are typical. The mol­ecules form dimers via a weak C—H⋯O inter­action described by the graph set R 2 2(10). The dimers are assembled in rows stacked in the crystallographic b-axis direction via π–π inter­actions with a 3.332 (3) Å separation between the rows

2-{[(4-Methoxy­phen­yl)dimethyl­silyl]meth­yl}isoindoline-1,3-dione

In the course of our studies of silicon-containing anti­cancer compounds, the title compound, C18H19NO3Si, was synthesized. The mol­ecular geometry including bond distances and angles involving the Si atoms are typical. Torsion angles associated with the isoindoline ring and the silyl group [C—N—Cmethyl­ene—Si = 90.5 (2) and −93.1 (2)°] indicate that there is no inter­action between the O and Si atoms despite silicon’s high affinity for oxygen

Impedance technology reveals correlations between cytotoxicity and lipophilicity of mono and bimetallic phosphine complexes

Label free impedance technology enables the monitoring of cell response patterns post treatment with drugs or other chemicals. Using this technology, a correlation between the lipophilicity of metal complexes and the degree of cytotoxicity was observed. Au(L1)Cl (1), AuPd(L1)(SC4H8)Cl3 (1a) and Au(L2)Cl (2) [L1 = diphenylphosphino-2-pyridine; L2 = 2-(2-(diphenylphosphino)ethyl)-pyridine] were synthesised, in silico drug-likeness and structure– activity relationship monitored using impedance technology. Dose dependent changes in cytotoxicity were observed for the metal complexes resulting in IC50s of 12.5 ± 2.5, 18.3 ± 8.3 and 16.9 ± 0.5 lM for 1, 1a and 2 respectively in an endpoint assay. When a real time impedance assay was used, dose-dependent responses depicting patterns that suggested slower uptake (at a toxic 20 lM) and faster recovery of the cells (at the less toxic 10 lM) of the bimetallic complex (1a) compared to the monometallic complexes (1 and 2) was observed. These data agreed with the ADMET findings of lower aqueous solubility of 1a and non-ideal lipophilicity (AlogP98 of 6.55) over more water soluble 1 and 2 with ideal lipophilicity (4.91 and 5.03 respectively) values. The additional coordination of a Pd atom to the nitrogen atom of a pyridine ring, the sulfur atom of a tetrahydrothiophene moiety and two chlorine atoms in 1a could be contributing to the observed differences when compared to the monometallic complexes. This report presents impedance technology as a means of correlating drug-likeness of lipophilic phosphine complexes containing similar backbone structures and could prove valuable in filtering drug-like compounds in a drug discovery project.Technology Innovation Agency (TIA), the University of Pretoria.Organization for Women in Science for the Developing World (OWSD) formerly Third World Organization for Women in Science (TWOWS) and University of Johannesburg.http://link.springer.com/journal/105342016-08-31hb201

Application of Additive Technologies for the Development of Microfluidic Chip Models of Rocks

В статье представлены результаты работы по апробации возможности применения современных и доступных аддитивных технологий на основе фотополимерного принтера для изготовления прототипов микрофлюидных устройств, пригодных для решения задач нефтегазовой индустрии. Исследовано два способа создания микрофлюидных устройств с помощью аддитивных технологий. Первый – изготовление мастер- формы для последующей отливки в ней ПДМС, второй – изготовление микрофлюидного чипа с полностью трехмерными каналами. Отработана методика создания мастер- формы с каналами необходимой геометрии для заливки ПДМС из фотоотверждаемого полимера методом стереолитографической печати. Данная методика была успешно протестирована на изготовлении микрофлюидного чипа с каналами минимальной ширины 100 мкм. Был спроектирован и изготовлен микрофлюидный чип с трехмерной структурой каналов. Показано, что с помощью печати мастер-формы для последующей отливки в ней ПДМС возможно изготавливать микрофлюидные чипы с шириной канала 100 мкм при высоте 50 мкм. Такие устройства могут найти своё применение при моделировании процессов нефтевытеснения из твёрдых горных породThe article presents the results of work on testing the possibility of using modern and affordable additive technologies based on a photopolymer printer for the manufacture of prototypes of microfluidic devices suitable for solving problems in the oil and gas industry. Two methods for creating microfluidic devices using additive technologies have been studied. The first one is the production of a master mold for subsequent casting of PDMS in it, the second is the production of a microfluidic chip with fully three-dimensional channels. A technique has been developed for creating a master mold with channels of the required geometry for pouring PDMS from a photocurable polymer using stereolithographic printing. This technique was successfully tested for the production of a microfluidic chip with channels with a minimum width of 100 μm. A microfluidic chip with a three-dimensional channel structure was designed and fabricated. It was shown that by printing a master mold for subsequent casting of PDMS in it, it is possible to produce microfluidic chips with a channel width of 100 μm and a height of 50 μm. Such devices can find their application in modeling processes of oil displacement from solid rock

Nucleophilicity of Neutral versus Cationic Magnesium Silyl Compounds

Charge and ancillary ligands affect the reactivity of monomeric tris(trimethylsilyl)silyl magnesium compounds. Diamine-coordinated (tmeda)Mg{Si(SiMe3)3}Me (tmeda = tetramethylethylenediamine; 2-tmeda) and (dpe)Mg{Si(SiMe3)3}Me (dpe =1,2-N,N-dipyrrolidenylethane; 2-dpe) are synthesized by salt elimination reactions of L2MgMeBr and KSi(SiMe3)3. Compounds 2-tmeda or 2-dpe react with MeI or MeOTf to give MeSi(SiMe3)3 as the product of Si–C bond formation. In contrast, 2-tmeda and 2-dpe undergo exclusively reaction at the magnesium methyl group with electrophiles such as Me3SiI, B(C6F5)3, HB(C6F5)2, and [Ph3C][B(C6F5)4]. These reactions provide a series of neutral, zwitterionic, and cationic magnesium silyl compounds, and from this series we have found that silyl group transfer is less effective with cationic magnesium compounds than neutral complexes

Experimental investigation of laminar forced convection of nanofluid in heat exchange equipment

The laminar forced convection in a recuperative heat exchanger operating with nanofluids with MgO nanoparticles was investigated experimentally. In the experiments, nanoparticle concentration varied in the range from 2.5 to 12 wt. %. The nanoparticle size equalled 50 nm. The viscosity and thermal conductivity coefficients of the nanosuspensions were experimentally determined. The dependence of the average heat transfer coefficient and pressure drop on the Reynolds number for nanofluids was obtained