4 research outputs found
The intraperitoneal bacteriology and antimicrobial resistance in acute appendicitis among children: a retrospective cohort study between the years 2007â2017
Characteristics of children admitted to hospital with acute SARS-CoV-2 infection in Canada in 2020
Background: Risk factors for severe outcomes of SARS-CoV-2 infection are not
well established in children. We sought
to describe pediatric hospital admissions associated with SARS-CoV-2 infection in Canada and identify risk factors
for more severe disease.
Methods: We conducted a national prospective study using the infrastructure of
the Canadian Paediatric Surveillance
Program (CPSP). Cases involving children who were admitted to hospital with
microbiologically confirmed SARS-CoV-2
infection were reported from Apr. 8 to
Dec. 31 2020, through weekly online
questionnaires distributed to the CPSP
network of more than 2800 pediatricians. We categorized hospital admissions as related to COVID-19, incidental,
or for social or infection control reasons
and determined risk factors for disease
severity in hospital.
Results: Among 264 hospital admissions
involving children with SARS-CoV-2
infection during the 9-month study
period, 150 (56.8%) admissions were
related to COVID-19 and 100 (37.9%)
were incidental infections (admissions
for other reasons and found to be positive for SARS-CoV-2 on screening).
Infants (37.3%) and adolescents (29.6%)
represented most cases. Among hospital
admissions related to COVID-19, 52
(34.7%) had critical disease, 42 (28.0%)
of whom required any form of respiratory or hemodynamic support, and 59
(39.3%) had at least 1 underlying
comorbidity. Children with obesity,
chronic neurologic conditions or
chronic lung disease other than asthma
were more likely to have severe or critical COVID-19.
Interpretation: Among children who
were admitted to hospital with SARSCoV-2 infection in Canada during the
early COVID-19 pandemic period, incidental SARS-CoV-2 infection was common. In children admitted with acute
COVID-19, obesity and neurologic and
respiratory comorbidities were associated with more severe disease.Medicine, Faculty ofNon UBCPediatrics, Department ofReviewedFacultyResearche