WebProt\'eg\'e: A Cloud-Based Ontology Editor

We present WebProt\'eg\'e, a tool to develop ontologies represented in the Web Ontology Language (OWL). WebProt\'eg\'e is a cloud-based application that allows users to collaboratively edit OWL ontologies, and it is available for use at https://webprotege.stanford.edu. WebProt\'ege\'e currently hosts more than 68,000 OWL ontology projects and has over 50,000 user accounts. In this paper, we detail the main new features of the latest version of WebProt\'eg\'e

Flames recognition for opinion mining

The emerging world-wide e-society creates new ways of interaction between people with different cultures and backgrounds. Communication systems as forums, blogs, and comments are easily accessible to end users. In this context, user generated content management revealed to be a difficult but necessary task. Studying and interpreting user generated data/text available on the Internet is a complex and time consuming task for any human analyst. This study proposes an interdisciplinary approach to modelling the flaming phenomena (hot, aggressive discussions) in online Italian forums. The model is based on the analysis of psycho/cognitive/linguistic interaction modalities among web communities' participants, state-of-the art machine learning techniques and natural language processing technology. Virtual communities' administrators, moderators and users could benefit directly from this research. A further positive outcome of this research is the opportunity to better understand and model the dynamics of web forums as the base for developing opinion mining applications focused on commercial applications

Decellularized homograft for aortic valve replacement two years after lung transplantation

Cardiac valvular surgery in patients after lung transplantation is a challenging procedure, reports are scarce. We report a 29-year-old patient who underwent concomitant mitral valve reconstruction and implantation of a decellularized aortic homograft two years after bilateral lung transplantation.Cardiac valvular surgery in patients after lung transplantation is a challenging procedure, reports are scarce. We report a 29-year-old patient who underwent concomitant mitral valve reconstruction and implantation of a decellularized aortic homograft two years after bilateral lung transplantation

Graphene oxide as a catalyst for the diastereoselective transfer hydrogenation in the synthesis of prostaglandin derivatives

[EN] Modification of GO by organic molecules changes its catalytic activity in the hydrogen transfer from i-propanol to enones, affecting the selectivity to allyl alcohol and diastereoselectivity to the resulting stereoisomers. It is noteworthy the system does not contain metals and is recyclable.Coman, SM.; Podolean, I.; Tudorache, M.; Cojocaru, B.; Parvulescu, VI.; Puche Panadero, M.; García Gómez, H. (2017). Graphene oxide as a catalyst for the diastereoselective transfer hydrogenation in the synthesis of prostaglandin derivatives. Chemical Communications. 53(74):10271-10274. doi:10.1039/c7cc05105kS1027110274537

Removal of xenoantigenic glycosylation patterns from porcine pulmonary heart valve matrices is dependent of the applied decellularization method

Department of Cardiac-, Thoracic-, Transplantation and Vascular Surgery, Hannover Medical School, Hannover Germany and Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Hannover Medical School, Hannover, Germany, The 6th International Medical Congress for Students and Young Doctors, May 12-14, 2016Introduction: Matrix guided tissue regeneration (GTR) based on allogeneic decellularized matrices has been shown as an overall convincing method for heart valve replacement. Nevertheless, a substantial donor shortage prevents an unlimited clinical application of human GTR-valves. Utilization of porcine decellularized heart valve matrices could offer a possible solution for overcoming this considerable limitation. In the past, implantation of xenogeneic valve tissues considered to be acellularinto human recipients, however, mostly lead to severe immune responses usually ending up into graft rejection. This study addresses the question whether potential xenoantigenic glycosylation of extracellular matrix components, like the major xenoantigen α-Gal, which served as model epitope for this study, can be removed by adjusted decellularization procedures. Materials and methods: Fresh porcine pulmonary heart valve conduits were decellularized by application of different detergent- and enzyme-based decellularization protocols. Subsequent cleavage of remaining matrix-related α-Gal epitopes was performed by enzymatic deglycosylation treatment on matrix samples of each decellularization group. Resulting tissues, mainly composed from insoluble extracellular matrix proteins, were afterwards divided into the relevant sections pulmonary artery wall specimens and pulmonary valve leaflets, frozen in liquid nitrogen, minced and finally solubilized by protease digestion. Evaluation of thus prepared solutions regarding to α-Gal contents was finally performed using a novel designed lectin-based immunoblot technique. Discussion results: Sole decellularization lead to significant removal of α-Gal, substantial varying in strong dependency to applied protocols between 30 to 50% compared to α-Gal contents of porcine native control tissues. An additional decrease of residual α-Gal in a range of another 15 to 30% was achievable by additional α-Galactosidase treatment. Combining decellularization and subsequent enzymatic digestion resulted in reductions of matrix related α-Gal contents down to levels, which could be measured for respective pulmonary valve tissues of α-Gal-KnockOut pigs. Conclusion: Residual xenoantigenic carbohydrates are detectable on insoluble matrix components of porcine pulmonary heart valves, substantially varying dependent on applied decellularization protocols. Combined with glycolytic digestions, remaining glycosylation contents are reducible to background levels. Impacts of these novel insights have to be evaluated in further in vitro as well as in vivo studies

OBSERVATIONS ON THE STRUCTURE, DYNAMICS AND ABBREVIATION OF ENTOMOFAUNE COLLECTED FROM CERTAIN AGRICULTURAL CROPS

The remarks were made in 2016 in the fruit tree, pear, peach, vine plantations, corn crops and cabbage crops, in two stations, stationary Vasile Adamachi, Iasi Iasi county and Ezereni farm in the Miroslava, Iasi County. The purpose of the paper was to compare the entomofauna by a number of different agricultural and field cultures, different as well as agroecosystem technology and conditions.The material was collected using the entomological filet, from June until September inclusive.The collected material was cleaned of vegetal remains and was then prepared for identification at species level. The analysis of the collected material shows that the samples collected belong to the Hexapoda Class, with several insect orders and the Arachnida Class, the Aranea order and the Acari order. Most of them belong to the Insecta class. The orders to which the species are collected are: Coleoptera, Heteroptera, Hymenoptera, Diptera, all of the Hexapoda class. As regards the abundance entomofauna, cultures, it is found that the wheat had been collected the multiple copies (69) followed by the growing of maize (39) and then planting vine (29) and plantations apple (24)

Non-invasive sampling of water-borne hormones demonstrates individual consistency of the cortisol response to stress in laboratory zebrafish (Danio rerio)

Animal science