Neuromodulation: present and emerging methods.

Neuromodulation has wide ranging potential applications in replacing impaired neural function (prosthetics), as a novel form of medical treatment (therapy), and as a tool for investigating neurons and neural function (research). Voltage and current controlled electrical neural stimulation (ENS) are methods that have already been widely applied in both neuroscience and clinical practice for neuroprosthetics. However, there are numerous alternative methods of stimulating or inhibiting neurons. This paper reviews the state-of-the-art in ENS as well as alternative neuromodulation techniques-presenting the operational concepts, technical implementation and limitations-in order to inform system design choices

Symmetry Based Properties of the Transition Metal Dichalcogenide Nanotubes

The full geometrical symmetry groups (the line groups) of the monolayered, 2Hb and 3R polytypes of the inorganic MoS2 and WS2 micro- and nanotubes of arbitrary chirality are found. This is used to find the coordinates of the representative atoms sufficient to determine completely geometrical structure of tubes. Then some physical properties which can be deduced from the symmetry are discussed: electron band degeneracies, selection rules, general forms of the second rank tensors and potentials, phonon spectra.Comment: 6 pages 1 figur

Atmospheric dispersion and the implications for phase calibration

The success of any ALMA phase-calibration strategy, which incorporates phase transfer, depends on a good understanding of how the atmospheric path delay changes with frequency (e.g. Holdaway & Pardo 2001). We explore how the wet dispersive path delay varies for realistic atmospheric conditions at the ALMA site using the ATM transmission code. We find the wet dispersive path delay becomes a significant fraction (>5 per cent) of the non-dispersive delay for the high-frequency ALMA bands (>160 GHz, Bands 5 to 10). Additionally, the variation in dispersive path delay across ALMA's 4-GHz contiguous bandwidth is not significant except in Bands 9 and 10. The ratio of dispersive path delay to total column of water vapour does not vary significantly for typical amounts of water vapour, water vapour scale heights and ground pressures above Chajnantor. However, the temperature profile and particularly the ground-level temperature are more important. Given the likely constraints from ALMA's ancillary calibration devices, the uncertainty on the dispersive-path scaling will be around 2 per cent in the worst case and should contribute about 1 per cent overall to the wet path fluctuations at the highest frequencies.Comment: 13 pages, 10 figures, ALMA Memo 59

Engineering Time-Reversal Invariant Topological Insulators With Ultra-Cold Atoms

Topological insulators are a broad class of unconventional materials that are insulating in the interior but conduct along the edges. This edge transport is topologically protected and dissipationless. Until recently, all existing topological insulators, known as quantum Hall states, violated time-reversal symmetry. However, the discovery of the quantum spin Hall effect demonstrated the existence of novel topological states not rooted in time-reversal violations. Here, we lay out an experiment to realize time-reversal topological insulators in ultra-cold atomic gases subjected to synthetic gauge fields in the near-field of an atom-chip. In particular, we introduce a feasible scheme to engineer sharp boundaries where the "edge states" are localized. Besides, this multi-band system has a large parameter space exhibiting a variety of quantum phase transitions between topological and normal insulating phases. Due to their unprecedented controllability, cold-atom systems are ideally suited to realize topological states of matter and drive the development of topological quantum computing.Comment: 11 pages, 6 figure

ALMA Temporal Phase Stability and the Effectiveness of Water Vapor Radiometer

Atacama Large Millimeter/submillimeter Array (ALMA) will be the world largest mm/submm interferometer, and currently the Early Science is ongoing, together with the commissioning and science verification (CSV). Here we present a study of the temporal phase stability of the entire ALMA system from antennas to the correlator. We verified the temporal phase stability of ALMA using data, taken during the last two years of CSV activities. The data consist of integrations on strong point sources (i.e., bright quasars) at various frequency bands, and at various baseline lengths (up to 600 m). From the observations of strong quasars for a long time (from a few tens of minutes, up to an hour), we derived the 2-point Allan Standard Deviation after the atmospheric phase correction using the 183 GHz Water Vapor Radiometer (WVR) installed in each 12 m antenna, and confirmed that the phase stability of all the baselines reached the ALMA specification. Since we applied the WVR phase correction to all the data mentioned above, we also studied the effectiveness of the WVR phase correction at various frequencies, baseline lengths, and weather conditions. The phase stability often improves a factor of 2 - 3 after the correction, and sometimes a factor of 7 improvement can be obtained. However, the corrected data still displays an increasing phase fluctuation as a function of baseline length, suggesting that the dry component (e.g., N2 and O2) in the atmosphere also contributes the phase fluctuation in the data, although the imperfection of the WVR phase correction cannot be ruled out at this moment.Comment: Proc. SPIE 8444-125, in press (7 pages, 4 figures, 1 table

Optimization of Quercetin Extraction from Green Tea (Camellia sinensis) Using Central Composite Design, and the Pharmacological Activity of the Extract

The aim of this paper was to optimize an extraction procedure of quercetin from green tea using central composite design. Extraction time, ethanol concentration, and solid to liquid ratio were selected as the independent variables, while quercetin yield was defined as a response. The impact of factors and their interactions on the quercetin yield was studied based on the results of ANOVA test. The extraction time of 58.5 min, ethanol concentration of 94.7 % (v/v), and solid to liquid ratio of 1:19.4 (m/v) were found as the optimal conditions. The experimental confirmation of the proposed optimal conditions indicated that there was a good agreement between the experimental and predicted values. In addition to quercetin, the presence of 17 bioactive compounds was confirmed in the green tea extract using mass spectrometry method. Antioxidant, antimicrobial and antitumor activity of the optimal extract was determined using DPPH assay, disk diffusion method, and MTT assay, respectively

Framework of the Virtual Construction Simulator 3 for construction planning and management education

Teaching construction planning and management is challenging, as construction projects are dynamic due to many varying and unforeseen factors. A growing number of construction-related simulations and games demonstrate the benefits of providing students with a realistic and interactive learning experience for knowledge applicable in real world situations. Currently, the majority of construction simulation games focus on teaching managerial skills either at an organizational level, or very specific project-based activities. To encourage broader adoption of simulation games for construction planning and management education, this research effort outlines a framework for the development of the Virtual Construction Simulator (VCS) game as an open-source, customizable and expandable simulation for different learning scenarios. The VCS prototype uses a small pavilion case study to teach students the decisions involved in planning, and subsequently managing the project construction affected by varying factors such as weather and labor productivity. The current prototype has been evaluated for its usability and effectiveness as a learning tool with over two hundred students in undergraduate and graduate-level courses, demonstrating benefits in engaging students in learning the challenges and risks in efficient construction planning and management. The paper outlines the VCS development framework, the system architecture, and the functionality based on the defined learning objectives. Evaluation results and future development steps are also discussed